Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura

Li, Zong-Nan; Zhang, Yuxuan; Zhang, Zhi-Ang; Pan, Lian-Han; Li, Ping; Xu, Yan; Sheng, Sheng; Wu, Fu‐An; Wang, Jun

doi:10.1007/s11356-022-20001-x

Cited by 2 publications

(2 citation statements)

References 55 publications

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“…The oil phase was initially introduced into the side channel, followed by the water into the main channel. The flow rates in both channels were continuously adjusted to facilitate the collection of the mixture and monitor it for signs of cloudiness or stratification (Li, Zhang, et al, 2022). The resulting mixture was collected and observed using the same procedure as described above after interchanging the aqueous and oil phases.…”

Section: Methodsmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

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This paper reports on the findings from a study that aimed to identify and characterize the constituents of Ocimum basilicum extract using gas chromatography–mass spectrometry (GC–MS) analysis, as well as assess the physicochemical properties and stability of nanoemulsions formulated with O. basilicum extract. The GC–MS analysis revealed that the O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for use in the biomedical field, with a small and uniform particle size distribution, a negative zeta potential, and high encapsulation efficiency for the O. basilicum extract. The nanoemulsions exhibited spherical morphology and remained physically stable for up to 6 months. In vitro release studies indicated sustained release of the extract from the nanoemulsion formulation compared to the free extract solution. Furthermore, the developed nanoformulation exhibited enhanced anticancer properties against K562 cells while demonstrating low toxicity in normal cells (HEK293). The O. basilicum extract demonstrated antimicrobial activity against Pseudomonas aeruginosa, Candida albicans, and Staphylococcus epidermidis, with a potential synergistic effect observed when combined with the nanoemulsion. These findings contribute to the understanding of the constituents and potential applications of O. basilicum extract and its nanoemulsion formulation in various fields, including healthcare and pharmaceutical industries. Further optimization and research are necessary to maximize the efficacy and antimicrobial activity of the extract and its nanoformulation.Research Highlights This study characterized the constituents of O. basilicum extract and assessed the physicochemical properties and stability of its nanoemulsion formulation. The O. basilicum extract contained 22 components, with Caryophyllene and Naringenin identified as the primary active constituents. The nanoemulsion formulation demonstrated excellent potential for biomedical applications, with sustained release of the extract, low toxicity, and enhanced anticancer and antimicrobial properties. The findings contribute to the understanding of the potential applications of O. basilicum extract and its nanoemulsion formulation in healthcare and pharmaceutical industries, highlighting the need for further optimization and research.

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Section: Methodsmentioning

confidence: 99%

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Ahmad,

Al‐dolaimy,

Kzar

et al. 2023

Microscopy Res & Technique

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“…As nanotechnology continues to evolve, using nanomaterials to encapsulate pesticides has proven to be beneficial. This approach enhances the stability of pesticide molecules, extends the duration of their slow-release properties, and reduces the amount of pesticides needed, owing to their minuscule size, large surface area, and powerful adsorption capacity, among other advantages. ,− Currently, the commonly utilized formulations of nanopesticide primarily encompass nanoemulsion pesticides, nanosuspension pesticides, and nano sustained-release formulations. − These commercially available sustained-release nanopesticide preparations can be integrated with agronomic models to achieve uniform seed sowing of pesticides, simultaneous application of pesticides and fertilizers, and to some extent fixed spraying. They have been partially implemented worldwide and have yielded certain achievements in crop pest and weed prevention and control. , Among these formulations, Vive Crop Protection , a Canadian company that has achieved relatively successful commercialization, has successfully developed various commercial pesticides by optimizing the stability of active ingredients during delivery using its Allosperse delivery system. , Notably, AZteroid FC3.3 (flagship product) has garnered significant attention due to its persistent disease control capability and good compatibility .…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

Ma,

Li,

et al. 2024

J. Agric. Food Chem.

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In an effort to make pesticide use safer, more efficient, and sustainable, micro-/nanocarriers are increasingly being utilized in agriculture to deliver pesticide-active agents, thereby reducing quantities and improving effectiveness. In the use of nanopesticides, the choice to further design and prepare pesticide stimulus-responsive nanocarriers based on changes in the plant growth environment (light, temperature, pH, enzymes, etc.) has received more and more attention from researchers. Based on this, this paper examines recent advancements in nanomaterials for the design of stimulus-responsive micro-/nanocarriers. It delves into the intricacies of preparation methods, material enhancements, in vivo/ex vivo controlled release, and application techniques for controlled release formulations. The aim is to provide a crucial reference for harnessing nanotechnology to pursue reduced pesticide use and increased efficiency.

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Microfluidic preparation of a novel phoxim nanoemulsion pesticide against Spodoptera litura

Cited by 2 publications

References 55 publications

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Microfluidic‐based nanoemulsion of Ocimum basilicum extract: Constituents, stability, characterization, and potential biomedical applications for improved antimicrobial and anticancer properties

Recent Advances in Stimulus-Responsive Nanocarriers for Pesticide Delivery

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