Microfluidic plug steering using surface acoustic waves

Şeşen, Muhsincan; Alan, Tuncay; Neild, Adrian

doi:10.1039/c5lc00468c

Cited by 57 publications

(57 citation statements)

References 61 publications

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“…Moreover, SAWs have been used to steer plugs completely or split them unevenly at a specially designed Y-junction ( Fig. 9(a),(b)) 172 . SAWs have been directed to the interface of the plugs to displace them into one or the other outlet which were not biased during the study 172 .…”

Section: Sortingmentioning

confidence: 99%

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Droplet control technologies for microfluidic high throughput screening (μHTS)

2017

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The transition from micro well plate and robotics based high throughput screening (HTS) to chip based screening has already started. This transition promises reduced droplet volumes thereby decreasing the amount of fluids used in these studies. Moreover, it significantly boosts throughput allowing screening to keep pace with the overwhelming number of molecular targets being discovered. In this review, we analyse state-of-the-art droplet control technologies that exhibit potential to be used in this new generation of screening devices. Since these systems are enclosed and usually planar, even some of the straightforward methods used in traditional HTS such as pipetting and reading can prove challenging to replicate in microfluidic high throughput screening (μHTS). We critically review the technologies developed for this purpose in depth, describing the underlying physics and discussing the future outlooks.

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Section: Sortingmentioning

confidence: 99%

“…9(a),(b)) 172 . SAWs have been directed to the interface of the plugs to displace them into one or the other outlet which were not biased during the study 172 . The system demonstrated here can sort larger plugs into any of the outlets (Fig.…”

Section: Sortingmentioning

confidence: 99%

Droplet control technologies for microfluidic high throughput screening (μHTS)

2017

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“…Firstly, for the focusing of beads [67], and soon after for the sorting of droplets [68]. Very recently the technique has been used for steering of slugs [69]. By using a tapered electrode geometry localized pressure fields can be created in the channel.…”

Section: Surface Acoustic Wavesmentioning

confidence: 99%

Droplet Manipulations in Two Phase Flow Microfluidics

2015

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Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.

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“…Recently, acoustic particle manipulation has also been implemented in droplet-based microfluidic systems for manipulation of whole droplets (Schmid et al 2014;Leibacher et al 2015;Sesen et al 2015) and focusing of particles and cells inside droplets (Fornell et al 2015Park et al 2017).…”

Section: Introductionmentioning

confidence: 99%

Intra-droplet acoustic particle focusing: simulations and experimental observations

Fornell

Garofalo

Nilsson

et al. 2018

Microfluid Nanofluid

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The aim of this paper is to study resonance conditions for acoustic particle focusing inside droplets in two-phase microfluidic systems. A bulk acoustic wave microfluidic chip was designed and fabricated for focusing microparticles inside aqueous droplets (plugs) surrounded by a continuous oil phase in a 380-μm-wide channel. The quality of the acoustic particle focusing was investigated by considering the influence of the acoustic properties of the continuous phase in relation to the dispersed phase. To simulate the system and study the acoustic radiation force on the particles inside droplets, a simplified 3D model was used. The resonance conditions and focusing quality were studied for two different cases: (1) the dispersed and continuous phases were acoustically mismatched (water droplets in fluorinated oil) and (2) the dispersed and continuous phases were acoustically matched (water droplets in olive oil). Experimentally, we observed poor acoustic particle focusing inside droplets surrounded by fluorinated oil while good focusing was observed in droplets surrounded by olive oil. The experimental results are supported qualitatively by our simulations. These show that the acoustic properties (density and compressibility) of the dispersed and continuous phases must be matched to generate a strong and homogeneous acoustic field inside the droplet that is suitable for high-quality intra-droplet acoustic particle focusing.

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Microfluidic plug steering using surface acoustic waves

Cited by 57 publications

References 61 publications

Droplet control technologies for microfluidic high throughput screening (μHTS)

Droplet control technologies for microfluidic high throughput screening (μHTS)

Droplet Manipulations in Two Phase Flow Microfluidics

Intra-droplet acoustic particle focusing: simulations and experimental observations

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