Microfluidic Particle Sorting System for Environmental Pollution Monitoring Applications

Tóth, Eszter L.; Holczer, Eszter; Földesy, Péter; Iván, Kristóf; Fürjes, Péter

doi:10.1016/j.proeng.2016.11.420

Cited by 7 publications

(5 citation statements)

References 2 publications

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“…Numerical modelling applications have been utilised for radionuclide separation [39][40][41], with computer automated design demonstrating potential alternatives to immediate prototyping. Finite element analysis (FEA) packages have previously been used to model fluid mechanics in various systems [42][43][44][45] to optimise mixing, separation, and bioparticle focusing. So far, optimisation of optical detection efficiency by modelling key design parameters prior to prototyping remains unexplored as a means of directing areas of development for LoC systems that rely on photon collection for radiometric analysis [13,[30][31][32].…”

Section: Introductionmentioning

confidence: 99%

“…There are many numerical modelling and ray-tracing methods that have been developed based on established modelling techniques for luminescence in microfluidic or portable systems [49][50][51][52][53][54]. These methods include applications for analytes of environmental [43,55,56], clinical [49,50,52,57], and forensic interest [53]. Here we present the foundations of best practices for developing novel radiometric prototypes.…”

Section: Introductionmentioning

confidence: 99%

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Rapid Prototyping Lab-on-Chip Devices for the Future: A Numerical Optimisation of Bulk Optical Parameters in Microfluidic Systems

Lu¹,

Morris²,

Clinton-Bailey³

et al. 2022

SSRN Journal

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rapid Prototyping Lab-on-Chip Devices for the Future: A Numerical Optimisation of Bulk Optical Parameters in Microfluidic Systems

Lu¹,

Morris²,

Clinton-Bailey³

et al. 2022

SSRN Journal

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“…This was first demonstrated in the classical experiment of Segré & Silberberg [10] where particles suspended in flow through a straight pipe with a circular cross-section were observed to migrate to an annular region approximately 0.6 times the radius of the pipe. The phenomenon of inertial migration has found many applications in medical and industrial settings such as isolation of circulating tumor cells (CTCs) [4,14,18], separation of particles and cells [5,6,17,19], flow cytometry [1], water filtration [11], extraction of blood plasma [8] and identification of small-scale pollutants in environmental samples [15]. Recent advances in inertial microfluidics are provided in several review articles [7,9,12,20].…”

Section: Introductionmentioning

confidence: 99%

Bifurcations in inertial focusing of a particle suspended in flow through curved rectangular ducts

Valani¹,

Harding²,

Stokes³

2021

Preprint

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Particles suspended in a fluid flow through a curved duct can focus to specific locations within the duct cross-section. This particle focusing is a result of a balance between two dominant forces acting on the particle: (i) the inertial lift force arising from small but non-negligible inertia of the fluid, and (ii) the secondary drag force due to the crosssectional vortices induced by the curvature of the duct. By adopting a simplified particle dynamics model developed by Ha et al. [2], we investigate both analytically and numerically, the particle equilibria and their bifurcations when a small particle is suspended in low-flow-rate fluid flow through a curved duct having a 2 × 1 and a 1 × 2 rectangular cross-section. In certain parameter regimes of the model, we analytically obtain the particle equilibria and deduce their stability, while for other parameter regimes, we numerically calculate the particle equilibria and stability. Moreover, we observe a number of different bifurcations in particle equilibria such as saddle-node, pitchfork and Hopf, as the model parameters are varied. These results may aid in the design of inertial microfluidic devices aimed at particle separation by size.

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“…There are numerous applications related to separation of particles having different physical characteristics, such as size and/or density. Examples include the isolation of circulating tumor cells from a blood sample [28], the filtering of bacteria and/or pollutants from a water sample [24], and the extraction of metals and minerals [18,29]. Designing optimal microfluidic devices for a diverse range of applications requires further advances in modelling to aid design.…”

mentioning

confidence: 99%

Inertial focusing of spherical particles in curved microfluidic ducts at moderate Dean numbers

Harding

Stokes²

2023

J. Fluid Mech.

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We examine the effect of Dean number on the inertial focusing of spherical particles suspended in flow through curved microfluidic ducts. Previous modelling of particle migration in curved ducts assumed the flow rate was small enough that a leading-order approximation of the background flow with respect to the Dean number produces a reasonable model. Herein, we extend our model to situations involving a moderate Dean number (in the microfluidics context) while the particle Reynolds number remains small. Variations in the Dean number cause a change in the axial velocity profile of the background flow which influences the inertial lift force on a particle. Simultaneously, changes in the cross-sectional velocity components of the background flow directly affect the secondary flow induced drag. In keeping the particle Reynolds number small, we continue to approximate the inertial lift force using a regular perturbation while capturing the subtle effects from the modified background flow. This approach pushes the limits at which a regular perturbation is applicable to provide some insights into how variations in the Dean number influence particle focusing. Our results illustrate that, as the extrema in the background flow move towards the outside of edge of the cross-section with increasing Dean number, we observe a similar shift in the stable equilibria of some, but not all, particle sizes. This might be exploited to enhance the lateral separation of particles by size in a number of practical scenarios.

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Microfluidic Particle Sorting System for Environmental Pollution Monitoring Applications

Cited by 7 publications

References 2 publications

Rapid Prototyping Lab-on-Chip Devices for the Future: A Numerical Optimisation of Bulk Optical Parameters in Microfluidic Systems

Rapid Prototyping Lab-on-Chip Devices for the Future: A Numerical Optimisation of Bulk Optical Parameters in Microfluidic Systems

Bifurcations in inertial focusing of a particle suspended in flow through curved rectangular ducts

Inertial focusing of spherical particles in curved microfluidic ducts at moderate Dean numbers

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