Microfluidic paper-based colorimetric quantification of malondialdehyde using silver nanoprism toward <i>on-site</i> biomedical analysis: a new platform for the chemical sensing and biosensing of oxidative stress

Bahavarnia, Farnaz; Baghban, Hossein Navay; Eskandani, Morteza; Hasanzadeh, Mohammad

doi:10.1039/d3ra06191d

Cited by 1 publication

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References 62 publications

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“…The concept behind microfluidic devices is to downsize a traditional laboratory into a miniaturized chip, incorporating various functions such as detection 1 , 2 , mixing 3 , 4 , synthesis 5 – 8 , and separation 9 – 11 at the micro- and nano-scale. These devices are extensively used in chemical analysis 12 , 13 , chemical synthesis 14 , 15 , and biomedical analysis 16 due to their speed, accuracy, and minimal reagent requirement. Efficient mixing holds significant importance in these devices, making the attainment of quick and uniform mixing with minimal fabrication complexity.…”

Section: Introductionmentioning

confidence: 99%

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Kheirkhah Barzoki

2024

Sci Rep

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Chemical bioreactions play a significant role in many of the microfluidic devices, and their applications in biomedical science have seen substantial growth. Given that effective mixing is vital for initiating biochemical reactions in many applications, micromixers have become increasingly prevalent for high-throughput assays. In this research, a numerical study using the finite element method was conducted to examine the fluid flow and mass transfer characteristics in novel micromixers featuring an array of pillars. The study utilized two-dimensional geometries. The impact of pillar configuration on mixing performance was evaluated using concentration distribution and mixing index as key metrics. The study explores the effects of pillar array design on mixing performance and pressure drop, drawing from principles such as contraction–expansion and split-recombine. Two configurations of pillar arrays, slanted and arrowhead, are introduced, each undergoing investigation regarding parameters such as pillar diameter, gap size between pillar groups, distance between pillars, and vertical shift in pillar groups. Subsequently, optimal micromixers are identified, exhibiting mixing efficiency exceeding 99.7% at moderate Reynolds number (Re = 1), a level typically challenging for micromixers to attain high mixing efficiency. Notably, the pressure drop remains low at 1102 Pa. Furthermore, the variations in mixing index over time and across different positions along the channel are examined. Both configurations demonstrate short mixing lengths and times. At a distance of 4300 μm from the inlet, the slanted and arrowhead configurations yielded mixing indices of 97.2% and 98.9%, respectively. The micromixers could provide a mixing index of 99.5% at the channel’s end within 8 s. Additionally, both configurations exceeded 90% mixing indices by the 3 s. The combination of rapid mixing, low pressure drop, and short mixing length positions the novel micromixers as highly promising for microfluidic applications.

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Section: Introductionmentioning

confidence: 99%

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Kheirkhah Barzoki

2024

Sci Rep

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Microfluidic paper-based colorimetric quantification of malondialdehyde using silver nanoprism toward on-site biomedical analysis: a new platform for the chemical sensing and biosensing of oxidative stress

Abstract: Malondialdehyde (MDA) is a critical product of polyunsaturated adipose acid peroxidation and represents a common biomarker of oxidative stress.

Cited by 1 publication

References 62 publications

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

Optimization of passive micromixers: effects of pillar configuration and gaps on mixing efficiency

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