Microfluidic paper-based analytical devices for environmental analysis of soil, air, ecology and river water

Kung, Chia Te; Hou, Chih‐Yao; Wang, Yao Nan; Fu, Lung-Ming

doi:10.1016/j.snb.2019.126855

Cited by 135 publications

(63 citation statements)

References 236 publications

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“…Accordingly, the application of µPAD in environmental analysis also receives a lot of attention. In this manner, readers are redirected to well-organized reviews by Meredith et al [ 186 ] and Kung et al [ 187 ]. Compared to other testing methods, environmental analysis seems not to be limited by a low amount of sample; however, it requires a dedicated study design and a careful sampling plan to collect representative samples from a vast heterogeneous area and preserve in proper condition to avoid sample degradation [ 188 ].…”

Section: Applications Of µPadsmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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Microfluidic paper-based analytical devices (µPADs) have become promising tools offering various analytical applications for chemical and biological assays at the point-of-care (POC). Compared to traditional microfluidic devices, µPADs offer notable advantages; they are cost-effective, easily fabricated, disposable, and portable. Because of our better understanding and advanced engineering of µPADs, multistep assays, high detection sensitivity, and rapid result readout have become possible, and recently developed µPADs have gained extensive interest in parallel analyses to detect biomarkers of interest. In this review, we focus on recent developments in order to achieve µPADs with high-throughput capability. We discuss existing fabrication techniques and designs, and we introduce and discuss current detection methods and their applications to multiplexed detection assays in relation to clinical diagnosis, drug analysis and screening, environmental monitoring, and food and beverage quality control. A summary with future perspectives for µPADs is also presented.

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Section: Applications Of µPadsmentioning

confidence: 99%

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

et al. 2020

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“…In this knowledgeable society, it is obvious the interest in developing low-cost, miniaturized and easy-to-use analytical devices that provide on-site quantitative information in a fast and easy way. The high potential of these devices makes them useful in very assorted fields: from clinical and biomedical applications [ 1 , 2 , 3 , 4 , 5 ] to food analysis and quality control [ 6 , 7 , 8 ], as well as environmental monitoring [ 9 , 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the last years, the development of paper-based electroanalytical devices has experienced an enormous increase and, although other kind of electrodes (e.g., metallic film and wires [ 39 , 40 , 41 ]) have been also integrated in these devices, paper-based SPEs continue to be among the most reported. SPEs printed on or integrated with paper-based devices have been developed for the construction of different types of biosensors (e.g., enzymatic, immunosensors, DNA/aptasensors), with many different designs and for a wide variety of applications (clinical, food or environmental analysis) [ 5 , 11 , 12 , 34 , 35 , 36 , 38 ]. Alternatively, paper and ink can be combined by simple deposition of a conductive carbon dispersion (WE), very useful when both paper faces are employed in the design of the electrochemical cell ( Figure 1 D) [ 15 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Paper-Based Screen-Printed Electrodes: A New Generation of Low-Cost Electroanalytical Platforms

Costa‐Rama

Fernández‐Abedul

2021

Biosensors

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Screen-printed technology has helped considerably to the development of portable electrochemical sensors since it provides miniaturized but robust and user-friendly electrodes. Moreover, this technology allows to obtain very versatile transducers, not only regarding their design, but also their ease of modification. Therefore, in the last decades, the use of screen-printed electrodes (SPEs) has exponentially increased, with ceramic as the main substrate. However, with the growing interest in the use of cheap and widely available materials as the basis of analytical devices, paper or other low-cost flat materials have become common substrates for SPEs. Thus, in this revision, a comprehensive overview on paper-based SPEs used for analytical proposes is provided. A great variety of designs is reported, together with several examples to illustrate the main applications.

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“…In recent years, paper has gained considerable attention as a substrate material for microfluidic devices thanks to not only its remarkable low cost and universal presence but, also, its mechanical properties, enabling the ease of fabrication/operation, lightness, flexibility and low thickness, as well as biocompatibility and biodegradability [ 1 , 2 ]. Considering the outstanding properties of paper materials, microfluidic paper-based analytical devices (µPADs) represent an innovative, equipment-independent [ 3 ] platform technology for fluid analysis, which is generally used for biological [ 4 ], environmental [ 1 , 5 , 6 , 7 ] and health applications [ 2 , 8 , 9 , 10 ]. µPADs enable microfluidic manipulations like transportation, mixing or separation within one analytical run, while allowing the analysis of complex and small amounts of biochemical samples (10 −9 to 10 −18 L) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Predicting Dimensions in Microfluidic Paper Based Analytical Devices

Catalan-Carrio

Akyazi

Basabe‐Desmonts

et al. 2020

Sensors

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The main problem for the expansion of the use of microfluidic paper-based analytical devices and, thus, their mass production is their inherent lack of fluid flow control due to its uncontrolled fabrication protocols. To address this issue, the first step is the generation of uniform and reliable microfluidic channels. The most common paper microfluidic fabrication method is wax printing, which consists of two parts, printing and heating, where heating is a critical step for the fabrication of reproducible device dimensions. In order to bring paper-based devices to success, it is essential to optimize the fabrication process in order to always get a reproducible device. Therefore, the optimization of the heating process and the analysis of the parameters that could affect the final dimensions of the device, such as its shape, the width of the wax barrier and the internal area of the device, were performed. Moreover, we present a method to predict reproducible devices with controlled working areas in a simple manner.

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Microfluidic paper-based analytical devices for environmental analysis of soil, air, ecology and river water

Cited by 135 publications

References 236 publications

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Recent Advances in Microfluidic Paper-Based Analytical Devices toward High-Throughput Screening

Paper-Based Screen-Printed Electrodes: A New Generation of Low-Cost Electroanalytical Platforms

Predicting Dimensions in Microfluidic Paper Based Analytical Devices

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