Microfluidic packaging of high-density CMOS electrode array for lab-on-a-chip applications

Chung, Jaehoon; Yuan, Hwang How; Chen, Yu; Lee, Tae Yoon

doi:10.1016/j.snb.2017.07.122

Cited by 15 publications

(8 citation statements)

References 32 publications

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“…The microfluidic based portable system show potential ability to precisely deliver samples to sensing domain [5][6][7][8][9]. Integration of microfluidic with Nano sensors allow ranges possible solutions in various applications, provide the design, fabrication and integration subsystem are compatible [10]. Often, the system require careful design consideration and reliable fabrication process that will produce desired size and shape [11].…”

Section: Introductionmentioning

confidence: 99%

Capillary Driven Muilti Channels Microfluidic

Hashim

Adam

Ehfaed³

et al. 2021

J. Phys.: Conf. Ser.

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The paper present design and fabrication of capillary driven muilti channels microfluidic. AutoCAD assisted layout design was conducted and fabricated based on cold photolithography process with precise geometry for capillary flow. The design was bonded with glass to test the flow and bonding integrity. The device was tested for flow and it was found the uniform capillary flow was established with strong bonding energy.

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Section: Introductionmentioning

confidence: 99%

Capillary Driven Muilti Channels Microfluidic

Hashim

Adam

Ehfaed³

et al. 2021

J. Phys.: Conf. Ser.

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“…The past three decades have witnessed the increasing role of miniaturized lab-on-a-chip systems in the development of biomedical, 1 bioengineering, 2 biosensor, 3 biophysical, 4 materials science, 5 medicine discovery, 6 and clinical diagnostics 7 fields. Hence, a variety of micro/nanomanipulation technologies have been developed to enable higher levels of functionality, versatility, programmability, automation, and miniaturization for lab-on-a-chip systems.…”

Section: Introductionmentioning

confidence: 99%

Optoelectrokinetics-based microfluidic platform for bioapplications: A review of recent advances

et al. 2019

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The introduction of optoelectrokinetics (OEK) into lab-on-a-chip systems has facilitated a new cutting-edge technique-the OEK-based micro/nanoscale manipulation, separation, and assembly processes-for the microfluidics community. This technique offers a variety of extraordinary advantages such as programmability, flexibility, high biocompatibility, low-cost mass production, ultralow optical power requirement, reconfigurability, rapidness, and ease of integration with other microfluidic units. This paper reviews the physical mechanisms that govern the manipulation of micro/nano-objects in microfluidic environments as well as applications related to OEK-based micro/nanoscale manipulation-applications that span from single-cell manipulation to single-molecular behavior determination. This paper wraps up with a discussion of the current challenges and future prospects for the OEK-based microfluidics technique. The conclusion is that this technique will allow more opportunities for biomedical and bioengineering researchers to improve lab-on-a-chip technologies and will have farreaching implications for biorelated researches and applications in the future.

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“…Microfluidic chips or Lab‐on‐a‐chip (LOC) technologies provide an excellent platform for research on biochemical analyses in micro or nano scale size. There are many advantages such as fast detection, small size, low cost and easy operation, especially suitable for on‐site biochemical analyses in extreme conditions such as space and underwater environments . In recent years, various microfluidic chip technologies have been developed and showed remarkable potential for studying C. elegans .…”

Section: Introductionmentioning

confidence: 99%

A novel microfluidic capture and monitoring method for assessing physiological damage of C. elegans under microgravity

et al. 2019

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Spatial microgravity is a significant factor affecting and causing physiological changes of organisms in space environment. On‐site assessment of the damage associated to microgravity is very important for future long‐term space exploration of mankind. In this paper, a new microfluidic device for analyzing the damage of microgravity on Caenorhabditis elegans (C. elegans) has been developed. This device is mainly composed of a microfluidic chip, a dual imaging module, and an imaging acquisition and processing module, which are integrated into a compact system. The microfluidic chip is designed as a platform for monitoring C. elegans, which is captured in an imaging region through a suction structure in the microfluidic chip. A dual imaging module is designed to obtain the images of bright field and fluorescence of C. elegans. The behaviors of C. elegans are analyzed based on the dual‐mode imaging of bright field and fluorescence to assess the degree of damage due to microgravity. A comparative study using a commercial microscope is also conducted to demonstrate the unique advantage of the developed system under the simulated microgravity. The results show that the developed system can evaluate the damage of C. elegans under microgravity accurately and conveniently. Furthermore, this device has compact size and weight, easy operation, and low‐cost, which could be highly advantageous for on‐site evaluation of the damage to microorganisms under microgravity in a space station.

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Microfluidic packaging of high-density CMOS electrode array for lab-on-a-chip applications

Cited by 15 publications

References 32 publications

Capillary Driven Muilti Channels Microfluidic

Capillary Driven Muilti Channels Microfluidic

Optoelectrokinetics-based microfluidic platform for bioapplications: A review of recent advances

A novel microfluidic capture and monitoring method for assessing physiological damage of C. elegans under microgravity

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