Microfluidic on-demand droplet merging using surface acoustic waves

Şeşen, Muhsincan; Alan, Tuncay; Neild, Adrian

doi:10.1039/c4lc00456f

Cited by 138 publications

(132 citation statements)

References 75 publications

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“…By using a tapered electrode geometry localized pressure fields can be created in the channel. In this local field a droplet can be trapped temporarily and then merged with a consecutive droplet [70,71]. Another way to localize the region where the pressure wave will occur is by using a PDMS pillar to connect the IDT substrate with the channel (see Figure 1h).…”

Section: Surface Acoustic Wavesmentioning

confidence: 99%

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Droplet Manipulations in Two Phase Flow Microfluidics

2015

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Even though droplet microfluidics has been developed since the early 1980s, the number of applications that have resulted in commercial products is still relatively small. This is partly due to an ongoing maturation and integration of existing methods, but possibly also because of the emergence of new techniques, whose potential has not been fully realized. This review summarizes the currently existing techniques for manipulating droplets in two-phase flow microfluidics. Specifically, very recent developments like the use of acoustic waves, magnetic fields, surface energy wells, and electrostatic traps and rails are discussed. The physical principles are explained, and (potential) advantages and drawbacks of different methods in the sense of versatility, flexibility, tunability and durability are discussed, where possible, per technique and per droplet operation: generation, transport, sorting, coalescence and splitting.

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Section: Surface Acoustic Wavesmentioning

confidence: 99%

“…Numerical simulations can be used to predict the acoustic field in a channel [72], and the displacement of a surface by the SAW can be measured using Laser Doppler vibrometry [70]. Recently, another optical technique has been developed which is able to measure the acoustic field in a microchannel directly [73].…”

Section: Surface Acoustic Wavesmentioning

confidence: 99%

Droplet Manipulations in Two Phase Flow Microfluidics

2015

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“…Eqn. (27) gives an expression for ∅ ;using this and the relation ∅ = × ∅ , Eqns. (19) or (20) will give ∅ .…”

Section: Modelling Of Air-filled Resonators a Details Of The Modelsmentioning

confidence: 99%

“…Capabilities such as positioning of particles in a single plane for filtration (acoustic filters) [20,21], within a microfluidic channel [22] and within three dimensions [23] have been demonstrated. It can also be used for particle sorting and separation [24,25], and for the production and manipulation of aqueous droplets in oil [26,27].…”

Section: Introductionmentioning

confidence: 99%

Optimisation of an acoustic resonator for particle manipulation in air

Devendran

Billson

Hutchins

et al. 2016

Sensors and Actuators B: Chemical

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(2015) Optimisation of an acoustic resonator for particle manipulation in air. Sensors and Actuators B: Chemical, 224 . pp. 529-538. Permanent WRAP URL:http://wrap.warwick.ac.uk/83726 Copyright and reuse:The Warwick Research Archive Portal (WRAP) makes this work by researchers of the University of Warwick available open access under the following conditions. Copyright © and all moral rights to the version of the paper presented here belong to the individual author(s) and/or other copyright owners. To the extent reasonable and practicable the material made available in WRAP has been checked for eligibility before being made available.Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. AbstractAn acoustic resonator system has been investigated for the manipulation and entrapment of micronsized particles in air. Careful consideration of the effect of the thickness and properties of the materials used in the design of the resonator was needed to ensure an optimised resonator. This was achieved using both analytical and finite-element modelling, as well as predictions of acoustic attenuation in air as a function of frequency over the 0.8 to 2.0 MHz frequency range. This resulted in a prediction of the likely operational frequency range to obtain particle manipulation. Experimental results are presented to demonstrate good capture of particles as small as 15 µm in diameter.

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“…16 As opposed to other manipulation methods such as dielectrophoresis and magnetophoresis, it is unaffected by particle charge, pH and ionic strength of the solutions. 14 In earlier work, acoustics have been applied to droplets in order to move microparticles inside sessile droplets surrounded by air, 17,18 manipulate entire droplets, 19,20 control droplet size, 21 steer and split plugs, 22 controlled merging, 23 and to align cells before single cell printing with a drop dispenser; 24 but this is the first time acoustic forces are used to position and enrich microparticles and cells inside moving droplets.…”

Section: Introductionmentioning

confidence: 99%

Controlled Lateral Positioning of Microparticles Inside Droplets Using Acoustophoresis

et al. 2015

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In this paper, we utilise bulk acoustic waves to control the position of microparticles inside droplets in two-phase microfluidic systems and demonstrate a method to enrich the microparticles. In droplet microfluidics different unit operations are combined and integrated on-chip to miniaturise complex biochemical assays. We present a droplet unit operation capable of controlling the position of microparticles during a trident shaped droplet split. An acoustic standing wave field is generated in the microchannel, and the acoustic forces direct the encapsulated microparticles to the centre of the droplets. The method is generic and requires no labelling of the microparticles, and is operated in a non-contact fashion. It was possible to achieve 2+fold enrichment of polystyrene beads (5 µm in diameter) in the centre daughter droplet with an average recovery of 89% of the beads. Red blood cells were also successfully manipulated inside droplets. These results show the possibility to use acoustophoresis in two-phase systems to enrich microparticles, and opens up for new dropletbased assays that are not possible to perform today.

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Microfluidic on-demand droplet merging using surface acoustic waves

Cited by 138 publications

References 75 publications

Droplet Manipulations in Two Phase Flow Microfluidics

Droplet Manipulations in Two Phase Flow Microfluidics

Optimisation of an acoustic resonator for particle manipulation in air

Controlled Lateral Positioning of Microparticles Inside Droplets Using Acoustophoresis

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