Microfluidic Mixing via Acoustically Driven Chaotic Advection

Frommelt, Thomas; Kostur, Marcin; Wenzel-Schäfer, Melanie; Talkner, Peter; Hänggi, Peter; Wixforth, Achim

doi:10.1103/physrevlett.100.034502

Cited by 220 publications

(196 citation statements)

References 17 publications

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“…But for a pair of groups using piezoelectric transducers, all the mixing technologies Nguyen and Wu described did not use acoustics. A later work by Frommelt et al (2008), the same group, used tapered IDT structures to drive mixing. One of the groups Nguyen and Wu did cite, Liu et al (2003), actually used near-field, cavitation-driven Schlichting streaming near microcavities machined into a polycarbonate plate, formed of air by capillary forces in immersion in water, and irradiated by thickness-mode vibration of a PZT plate.…”

Section: Chemistrymentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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This article reviews acoustic microfluidics: the use of acoustic fields, principally ultrasonics, for application in microfluidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

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Section: Chemistrymentioning

confidence: 99%

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

2011

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“…Similarly, the interaction of sound waves and vibrations with fluids has an equally rich history dating back to Faraday's 11 observation of capillary waves on vertically vibrated substrates and Rayleigh's 12 description of acoustic streaming in air-filled resonant tubes. It has, however, only been in the last decade that renewed interest has emerged in the subject, particularly surrounding flows arising from nanometer amplitude highfrequency (MHz order) substrate vibration in the form of surface acoustic waves (SAWs) 13 , not only because of their tremendous potential for driving a variety of microfluidic operations such as drop transport 14 , fluid mixing 15 and particle/ cell alignment 16 , but also because of the recent discovery of associated phenomena such as dynamic colloidal patterning 17 and interfacial jetting 18 . Here we report on a novel collection of dynamic spreading and flow-instability phenomena that arise when a sessile fluid drop is subjected to the SAW.…”

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confidence: 99%

Unique fingering instabilities and soliton-like wave propagation in thin acoustowetting films

et al. 2012

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Acoustic-fluid interactions not only has had a long history but has recently experienced renewed scrutiny because of their vast potential for microscale fluid and particle manipulation. Here we unravel a fascinating and anomalous ensemble of dynamic 'acoustowetting' phenomena in which a thin film drawn from a sessile drop first spreads in opposition to the acoustic wave propagation direction. The advancing film front then exhibits fingering instabilities akin to classical viscous fingering, but arising through a different and novel mechanism: transverse Fresnel diffraction of the underlying acoustic wave. Peculiar 'solitonlike' wave pulses are observed to grow above these fingers, which, on reaching a critical size, translate away along the wave propagation direction. By elucidating the complex hydrodynamics underpinning the spreading, and associated flow reversal and instability phenomena, we offer insight into the possibility of acoustically controlling fast and uniform film spreading, constituting a flexible and powerful alternative for microfluidic transport.

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“…To date, many acoustic-based particle manipulation functions (e.g., focusing, separating, sorting, mixing, and patterning) have been realized (25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43). None of these approaches, however, have achieved the dexterity of optical tweezers; in other words, none of the previous acoustic-based methods are capable of precisely manipulating single microparticles or cells along an arbitrary path in two dimensions.…”

mentioning

confidence: 99%

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

Ding

Lin

Kiraly

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

778

590

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Techniques that can dexterously manipulate single particles, cells, and organisms are invaluable for many applications in biology, chemistry, engineering, and physics. Here, we demonstrate standing surface acoustic wave based “acoustic tweezers” that can trap and manipulate single microparticles, cells, and entire organisms (i.e., Caenorhabditis elegans ) in a single-layer microfluidic chip. Our acoustic tweezers utilize the wide resonance band of chirped interdigital transducers to achieve real-time control of a standing surface acoustic wave field, which enables flexible manipulation of most known microparticles. The power density required by our acoustic device is significantly lower than its optical counterparts (10,000,000 times less than optical tweezers and 100 times less than optoelectronic tweezers), which renders the technique more biocompatible and amenable to miniaturization. Cell-viability tests were conducted to verify the tweezers’ compatibility with biological objects. With its advantages in biocompatibility, miniaturization, and versatility, the acoustic tweezers presented here will become a powerful tool for many disciplines of science and engineering.

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Microfluidic Mixing via Acoustically Driven Chaotic Advection

Cited by 220 publications

References 17 publications

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

Unique fingering instabilities and soliton-like wave propagation in thin acoustowetting films

On-chip manipulation of single microparticles, cells, and organisms using surface acoustic waves

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