Microfluidic imaging: A novel concept for pixelation of chemical and biological samples

Tachikawa, Kaoru; Dittrich, Petra S.; Manz, Andreas

doi:10.1016/j.snb.2009.01.032

Cited by 5 publications

(5 citation statements)

References 39 publications

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“…Pixelation of chemical and biological samples in droplets suspended in a two-phase microflow has been demonstrated by Tachikawa (429). Sarrazin et al used droplets for chemical reaction imaging using confocal Raman spectroscopy (430).…”

Section: Applicationsmentioning

confidence: 99%

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Latest Developments in Micro Total Analysis Systems

et al. 2010

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The field of micro total analysis systems (µTAS) (1) or lab on a chip (LOC) has extended its usefulness into many new fields and disciplines spanning basic research to commercial applications. The importance of µTAS is reflected in both the growing number and improved quality of published articles. µTAS has expanded into an incredibly diverse number of analytical chemistry applications and has received a great amount of input from a wide spectrum of scientific and engineering disciplines. In this sense, µTAS is highly interdisciplinary and has served as a focal point to bring together multidisciplinary research fields.This work builds on former reviews (2-6) and attempts to chart the most recent developments in µTAS. By cross referencing online keyword searches, several thousand articles were found spread among a wide variety of journals but were most frequently found in the high impact journals such as Science, Nature, PNAS, Analytical Chemistry, Lab on a Chip, and others. The annual international µTAS conference also provided articles on some of the very latest and most promising developments. This review article aims to report the latest achievements in the field of µTAS by highlighting some of the very best research papers published over the 2 year period between March 2008 and February 2010. Our main goal is to give a broad overview of the latest state-ofthe-art research and to introduce newcomers to the field. We were overwhelmed by the large number of research papers published on cellular analysis, manipulation, and droplet fluidics; therefore, we divided the review into two parts. This first part concentrates on reports related to manufacturing, technology, and instrumentation for molecular analysis, and part two covers applications related to cellular analysis and manipulation, which is referred to as cellson-a-chip (460). The papers we selected on droplet fluidics are distributed throughout both parts of the article according to their applications. We attempted to select papers based on the merit of their contents, which was a difficult task, and we have missed some good articles; for these oversights, we offer our apology in advance.Since this review focuses on novel developments of microfluidic systems for applied analytical chemical applications, publications about sensor arrays (so-called "biochips"), chemical synthesis on microchips (except some papers on particle synthesis using droplets), theory, and simulations, as well as trend articles, have been omitted. Furthermore, we reduced the technology section, as the majority of work is carried out by employing simple planar microchips fabricated in glass or polymers such as silicone elastomers. TECHNOLOGYMicrofabrication. Conventional Microfabrication. Many new innovative approaches have been reported in the field of microfabrication. Semicircular cross section channels network microfabricated on a silicon chip by XeF 2 etching by Camp et al. (7). These channels allow stress free transportation of cells. Generally, vapor deposited thin film metal ele...

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Section: Applicationsmentioning

confidence: 99%

“…Albritton and co-workers have coated a glass/PDMS hybrid device with bilayer membranes by vesicle fusion . Pixelation of chemical and biological samples in droplets suspended in a two-phase microflow has been demonstrated by Tachikawa . Sarrazin et al used droplets for chemical reaction imaging using confocal Raman spectroscopy .…”

Section: Applicationsmentioning

confidence: 99%

Latest Developments in Micro Total Analysis Systems

et al. 2010

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“…Microfluidic devices have been applied in a lot of fields (Abdelgawad et al 2009;Chen et al 2007;Davidsson et al 2004;Duffy et al 1999;Desmet and Baron 2000;Escarpa et al 2008;Fan et al 2008;Hofmann et al 2001;Ito et al 2009;McKnight et al 2001;Park et al 2007; Rhee and Burns 2008;Tachi et al 2009;Tachikawa et al 2009;Weng et al 2009;Xu et al 2008;Xu and Shuler 2009;Yuen et al 2009). Most of them use the syringe pumps as driving sources (Chen et al 2007;Davidsson et al 2004;Hofmann et al 2001;Ito et al 2009;Rhee and Burns 2008;Tachi et al 2009;Tachikawa et al 2009;Yuen et al 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Most of them use the syringe pumps as driving sources (Chen et al 2007;Davidsson et al 2004;Hofmann et al 2001;Ito et al 2009;Rhee and Burns 2008;Tachi et al 2009;Tachikawa et al 2009;Yuen et al 2009). There are also other methods proposed among the literature to drive the fluids in the microchannels.…”

Section: Introductionmentioning

confidence: 99%

Modular component design for portable microfluidic devices

Liou¹,

Hsieh

Kuo

et al. 2010

Microfluid Nanofluid

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A new modular design concept for microfluidic devices is proposed and demonstrated in this study. We designed three key modular microfluidic components: pumps, valves, and reservoirs, and demonstrated that a microfluidic device with specific functions can be easily assembled with those key modular components. Our pumps are man-powerable so that the assembled microfluidic devices require no any other power sources like expensive syringe pumps or air compressors. This feature makes the assembled microfluidic devices completely portable. We also combined our assembled device with other existing mixing microchannels to serve as the mixing and loading system in polymerase chain reaction experiment to amplify DNA successfully. This result shows that those modular components can be integrated into other microchannels, implying great potential applications of the modular design.

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“…f) Transporte en medios mesoporosos, como los que se muestran en la referencia [103]. g) Microdiseños para el análisis de muestras, imagen tomada de la referencia [104]. h) Catálisis en nano-reactores (véase la referencia [105] y los trabajos allí citados).…”

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Sobre la difusión en sistemas confinados: una aproximación al estudio de la difusión en canales

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Microfluidic imaging: A novel concept for pixelation of chemical and biological samples

Cited by 5 publications

References 39 publications

Latest Developments in Micro Total Analysis Systems

Latest Developments in Micro Total Analysis Systems

Modular component design for portable microfluidic devices

Sobre la difusión en sistemas confinados: una aproximación al estudio de la difusión en canales

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