Microfluidic fabrication using cyclic olefin copolymer and hydrocarbon solvents

Agha, Abdulrahman; Dawaymeh, Fadi; Alamoodi, Nahla; Abu‐Nada, Eiyad; Alazzam, Anas

doi:10.1016/j.eurpolymj.2023.112329

Cited by 4 publications

(2 citation statements)

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“…Some electroactive polymers and gels are found to be helpful in biomedical applications, especially in drug delivery, artificial tissue development and microfluidics. [22][23][24][25][26][27] Redoxresponsive polymer gels can be used to trigger the release of therapeutic agents, providing a method to dissolve and remove the gel matrix after its application. 28 Functional electroactive polymers are classified as conducting polymers with a system of conjugated p-bonds 29 and redoxpolymers, which has separate redox-centers, such as organosulfur polymers, 30 nitroxide radical tetramethylpiperidine-Noxyl (TEMPO)-based polymers, 31 pendant-type polymers based on ferrocene and carbazole, 32,33 aromatic carbonyl derivatives and quinine-based materials.…”

Section: Introductionmentioning

confidence: 99%

“…Some electroactive polymers and gels are found to be helpful in biomedical applications, especially in drug delivery, artificial tissue development and microfluidics. 22–27 Redox-responsive polymer gels can be used to trigger the release of therapeutic agents, providing a method to dissolve and remove the gel matrix after its application. 28…”

Section: Introductionmentioning

confidence: 99%

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Thermodynamic model for voltammetric responses in conducting redox polymers

Anishchenko,

Vereshchagin,

Kalnin

et al. 2024

Phys. Chem. Chem. Phys.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thermodynamic model for voltammetric responses in conducting redox polymers

Anishchenko,

Vereshchagin,

Kalnin

et al. 2024

Phys. Chem. Chem. Phys.

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Enhancing fabrication of hybrid microfluidic devices through silane‐based bonding: A focus on polydimethylsiloxane‐cyclic olefin copolymer and PDMS‐lithium niobate

Agha,

Dawaymeh,

Alamoodi

et al. 2024

Applied Research

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Effective manipulation and control of fluids in microfluidic channels requires robust bonding between the different components. Polydimethylsiloxane (PDMS) is widely employed in microchannel fabrication due to its affordability, biocompatibility, and straightforward fabrication process. However, PDMS's low surface energy poses challenges in bonding with many organic and inorganic substrates, hindering the development of hybrid microfluidic devices. In this study, a simple and versatile three step process is presented for bonding PDMS microchannels with organic (cyclic olefin copolymer (COC)) and inorganic substrates (lithium niobate (LiNbO3)) using plasma activation and a silane coupling agent. Initially, the PDMS surface undergoes oxygen/argon plasma activation, followed by functionalization with (3‐aminopropyl) triethoxysilane (APTES). Subsequently, the COC or LiNbO3 is plasma activated and brought into contact with PDMS under a load at a specific temperature. Characterization by FTIR, SEM, AFM, and contact angle measurements confirmed the successful treatment of the substrates. In addition, bonding strength of the fabricated hybrid devices was assessed through leakage and tensile tests. Under optimized conditions (100°C and 4% v/v APTES), PDMS‐COC hybrid microchannels achieved a flow rate of 600 mL/h without leakage and a tensile strength of 562 kPa. Conversely, the PDMS‐ LiNbO3 assembly demonstrated a flow rate of 216 mL/h before leakage, with a tensile strength of 334 kPa. This bonding method exhibits significant potential and versatility for various materials in microfluidic applications, ranging from biomedical research to enhanced oil recovery (EOR).This article is protected by copyright. All rights reserved.

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