Microfluidic fabrication of size-controlled nanocarriers with improved stability and biocompatibility for astaxanthin delivery

Guo, Meng; Cui, Weina; Li, Yuanchao; Fei, Siyuan; Sun, Chaofan; Tan, Miaomiao; Su, Wentao

doi:10.1016/j.foodres.2023.112958

Cited by 3 publications

(3 citation statements)

References 47 publications

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“…The synthesis of AXT-ACN NPs was based on our previous report [17]. Briefly, 1 mg/mL of AXT ethanolic solution was used as the internal phase; 0.75 mg/mL of lysine aqueous solution and 60 µL formaldehyde served as the mesophase; and 3 mg/mL ACN aqueous solution was used as the external phase.…”

Section: Preparation Of Axt-acn Npsmentioning

confidence: 99%

“…Therefore, it is highly desirable to apply advanced nanocarriers for improved bioavailability of AXT. In our previous work, astaxanthin-anthocyanin nanoparticles (AXT-ACN NPs) were successfully prepared by a microfluidic strategy through the Mannich reaction, which has been proved to have enhanced stability under high temperature, low pH, and UV irradiation [17]. Given anthocyanin exhibits great capability in lipid lowering and good antioxidant activity, it can be speculated that AXT-ACN NPs would have a positive effect on alleviating the health risks caused by obesity [18].…”

Section: Introductionmentioning

confidence: 99%

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Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat Caenorhabditis elegans

Yu,

Guo,

Tan

et al. 2024

Foods

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Obesity has become a serious global public health risk threatening millions of people. In this study, the astaxanthin–anthocyanin nanoparticles (AXT-ACN NPs) were used to investigate their effects on the lipid accumulation and antioxidative capacity of the high-sugar-diet-induced high-fat Caenorhabditis elegans (C. elegans). It can be found that the lifespan, motility, and reproductive capacity of the high-fat C. elegans were significantly decreased compared to the normal nematodes in the control group. However, treatment of high-fat C. elegans with AXT-ACN NPs resulted in a prolonged lifespan of 35 days, improved motility, and a 22.06% increase in total spawn production of the nematodes. Furthermore, AXT-ACN NPs were found to effectively extend the lifespan of high-fat C. elegans under heat and oxidative stress conditions. Oil-red O staining results also demonstrated that AXT-ACN NPs have a remarkable effect on reducing the fat accumulation in nematodes, compared with pure astaxanthin and anthocyanin nanoparticles. Additionally, AXT-ACN NPs can significantly decrease the accumulation of lipofuscin and the level of reactive oxygen species (ROS). The activities of antioxidant-related enzymes in nematodes were further measured, which revealed that the AXT-ACN NPs could increase the activities of catalase (CAT), superoxidase dismutase (SOD), and glutathione peroxidase (GSH-Px), and decrease the malondialdehyde (MDA) content. The astaxanthin and anthocyanin in AXT-ACN NPs showed sound synergistic antioxidation and lipid-lowering effects, making them potential components in functional foods.

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Section: Preparation Of Axt-acn Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat Caenorhabditis elegans

Yu,

Guo,

Tan

et al. 2024

Foods

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“…Enhanced ROS accumulation, caused mitochondrial damage, and regulated apoptosis. [156] Lycopene Nanofibers Gelatin Improved water solubility. Enhanced antioxidant activity during 14-day storage.…”

Section: Nanocomplexes Whey Proteinmentioning

confidence: 99%

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Ortega-Regules,

Martínez-Thomas,

Schürenkämper-Carrillo

et al. 2024

Plants

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Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided.

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Microfluidic fabrication of core–shell fucoxanthin nanofibers with improved environmental stability for reducing lipid accumulation in vitro

Tian,

Li,

Wang

et al. 2024

Food Chemistry

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Microfluidic fabrication of size-controlled nanocarriers with improved stability and biocompatibility for astaxanthin delivery

Cited by 3 publications

References 47 publications

Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat Caenorhabditis elegans

Lipid-Lowering and Antioxidant Effects of Self-Assembled Astaxanthin–Anthocyanin Nanoparticles on High-Fat Caenorhabditis elegans

Recent Advances in the Therapeutic Potential of Carotenoids in Preventing and Managing Metabolic Disorders

Microfluidic fabrication of core–shell fucoxanthin nanofibers with improved environmental stability for reducing lipid accumulation in vitro

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