Microfluidic emulsification devices: from micrometer insights to large-scale food emulsion production

Schroën, Karin; Bliznyuk, Olesya; Muijlwijk, Kelly; Şahin, Sami; Berton‐Carabin, Claire C.

doi:10.1016/j.cofs.2014.11.009

Cited by 71 publications

(61 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…are used, but these are not known for their control of droplet size. In that respect, the microstructured devices that are becoming of age nowadays, may be interesting alternatives, although it should be mentioned that throughput may still be an issue (Schroën et al 2015, Yuan & Williams 2014).…”

Section: Emulsion-based Systemsmentioning

confidence: 98%

Food-grade micro-encapsulation systems that may induce satiety via delayed lipolysis: A review

Corstens

Berton‐Carabin

Vries

et al. 2015

Critical Reviews in Food Science and Nutrition

Self Cite

View full text Add to dashboard Cite

The increasing prevalence of overweight and obesity requires new, effective prevention and treatment strategies. One approach to reduce energy intake is by developing novel foods with increased satiating properties, which may be accomplished by slowing down lipolysis to deliver substrates to the ileum, thereby enhancing natural gut-brain signaling pathways of satiety that are normally induced by meal intake. To develop slow release food additives, their processing in the gastrointestinal tract has to be understood; therefore, we start from a general description of the digestive system and relate that to in vitro modeling, satiety, and lipolytic mechanisms. The effects of physicochemical lipid composition, encapsulation matrix, and interfacial structure on lipolysis are emphasized. We give an overview of techniques and materials used, and discuss partitioning, which may be a key factor for encapsulation performance. Targeted release capsules that delay lipolysis form a real challenge because of the high efficiency of the digestive system; hardly any proof was found that intact orally ingested lipids can be released in the ileum and thereby induce satiety. We expect that this challenge could be tackled with structured o/w-emulsion-based systems that have some protection against lipase, e.g., by hindering bile salt adsorption and/or delaying lipase diffusion.

show abstract

Section: Emulsion-based Systemsmentioning

confidence: 98%

Food-grade micro-encapsulation systems that may induce satiety via delayed lipolysis: A review

Corstens

Berton‐Carabin

Vries

et al. 2015

Critical Reviews in Food Science and Nutrition

Self Cite

View full text Add to dashboard Cite

show abstract

“…Membrane emulsification was successfully used to prepare monodisperse microcapsules at low energy consumption; this also resulted in better control over the size and size distribution . Membrane emulsification can be conducted in different manners, including cross‐flow, microchannel, and premix membrane emulsification . In cross‐flow and microchannel emulsification, the dispersed phase is pushed through the fine pores of the membrane, and the continuous phase shears them off at the opening of the pores to form relatively uniform and small droplets .…”

Section: Introductionmentioning

confidence: 99%

“…Membrane emulsification can be conducted in different manners, including cross‐flow, microchannel, and premix membrane emulsification . In cross‐flow and microchannel emulsification, the dispersed phase is pushed through the fine pores of the membrane, and the continuous phase shears them off at the opening of the pores to form relatively uniform and small droplets . Although these droplets are highly monodisperse, the production yield is rather low.…”

Section: Introductionmentioning

confidence: 99%

“…Upon passage of the membrane, the large droplets are broken up into smaller ones, and repeating this process several times may result in relatively uniform and small droplets. Different types of microporous membranes, including glass, polymeric, metallic, and ceramic membranes, have been reported in the literature for the preparation of emulsions and microcapsules, but there have also been issues related to the fouling and blockage of membranes due to interactions with emulsion ingredients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Preparation of polylactide microcapsules at a high throughput with a packed‐bed premix emulsification system

Sawalha

Şahin

Schroën

2016

J of Applied Polymer Sci

Self Cite

View full text Add to dashboard Cite

Core–shell polymer microcapsules are well known for their biomedical applications as drug carriers when they are filled with drugs and gas‐filled microcapsules that can be used as ultrasound contrast agents. The properties of microcapsules are strongly dependent on their size (distribution); therefore, equipment that allows the preparation of small and well‐defined microcapsules is of great practical relevance. In this study, we made polylactide microcapsules with a packed‐bed premix emulsification system that previously gave good results for regular emulsions. Here, we tested it for applicability to a system in which droplets shrank and solidified to obtain capsules. The packed‐bed column was loaded with glass beads of different sizes (30–90 µm) at various bed heights (2–20 mm), and coarse emulsions consisting of the polymer, a solvent, and a nonsolvent were pushed repeatedly through this system at selected applied pressures (1–4 bar). The obtained transmembrane fluxes (100–1000 m3 m−2 h−1) were much higher than those recorded for other membrane emulsification techniques. The average size of the obtained microcapsules ranged between 2 and 8 µm, with an average span of about 1; interestingly, the capsules were 2–10 times smaller than the interstitial voids of the beds. The droplets were larger when we used thicker beds and larger glass beads, and these effect correlated with the pore Reynolds number (Rep). Two breakup mechanisms were identified: spontaneous droplet snap‐off dominated the system at low Reps, and localized shear forces dominated the system at higher Rep. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43536.

show abstract

“…The main limitations of ME for industrial scale production are in low emulsion throughputs and membrane fouling . In order to produce 1 m 3 h −1 of a 30% emulsion with a droplet size of 5−10 µm, the required membrane area in shear-based DME is 5−60 m 2 (Schroën et al, 2015). 3…”

Section: Membrane Emulsificationmentioning

confidence: 99%

Structured microparticles with tailored properties produced by membrane emulsification

Vladisavljević

2015

Advances in Colloid and Interface Science

View full text Add to dashboard Cite

This paper provides an overview of membrane emulsification routes for fabrication of structured microparticles with tailored properties for specific applications. Direct (bottom-up) and premix (top-down) membrane emulsification processes are discussed including operational, formulation and membrane factors that control the droplet size and droplet generation regimes. A special emphasis was put on different methods of controlled shear generation on membrane surface, such as cross flow on the membrane surface, swirl flow, forward and backward flow pulsations in the continuous phase and membrane oscillations and rotations. Droplets produced by membrane emulsification can be used for synthesis of particles with versatile morphology (solid and hollow, matrix and core/shell, spherical and non-spherical, porous and coherent, composite and homogeneous), which can be surface functionalised and coated or loaded with macromolecules, nanoparticles, quantum dots, drugs, phase change materials and high molecular weight gases to achieve controlled/targeted drug release and impart special optical, chemical, electrical, acoustic, thermal and magnetic properties. The template emulsions including metal-in-oil, solid-in-oil-in-water, oil-in-oil, multilayer, and Pickering emulsions can be produced with high encapsulation efficiency of encapsulated materials and narrow size distribution and transformed into structured particles using a variety of different processes, such as polymerisation (suspension, mini-emulsion, interfacial and in-situ), ionic gelation, chemical crosslinking, melt solidification, internal phase separation, layer-by-layer electrostatic deposition, particle self-assembly, complex coacervation, spray drying, sol-gel processing, and molecular imprinting. Particles fabricated from droplets produced by membrane emulsification include nanoclusters, colloidosomes, carbon aerogel particles, nanoshells, polymeric (molecularly imprinted, hypercrosslinked, Janus and core/shell) particles, solder metal powders and inorganic particles. Membrane 2 emulsification devices operate under constant temperature due to low shear rates on the membrane surface, which range from (1−10) × 10 3 s −1 in a direct process to (1−10) × 10 4 s −1 in a premix process.Keywords: Membrane Emulsification; Polymeric microsphere; Microgel; Janus Particle; Core/Shell Particle, Colloidosome. Membrane emulsificationMembrane emulsification (ME) involves preparation of emulsions by pressing a pure dispersed phase or pre-emulsified mixture of the dispersed and continuous phase through a microporous membrane under controlled injection rate and shear conditions. In direct membrane emulsification (DME), one liquid (a dispersed phase) is injected through a microporous membrane into another immiscible liquid (the continuous phase) (Nakashima et al., 1991;, which leads to the formation of droplets at the membrane/continuous phase interface ( Figure 1a). In premix membrane emulsification (PME) (Figure 1b), a pre-emulsion is pressed through the membrane (...

show abstract

Microfluidic emulsification devices: from micrometer insights to large-scale food emulsion production

Cited by 71 publications

References 59 publications

Food-grade micro-encapsulation systems that may induce satiety via delayed lipolysis: A review

Food-grade micro-encapsulation systems that may induce satiety via delayed lipolysis: A review

Preparation of polylactide microcapsules at a high throughput with a packed‐bed premix emulsification system

Structured microparticles with tailored properties produced by membrane emulsification

Contact Info

Product

Resources

About