Microfluidic disk for the determination of human blood types

Li, Haiwen; Wu, Ligang; Zhou, Wuping; Jiang, Keming; Fu, Weiwei; Dong, Yue-fang; Chen, Shi; Liu, Cong; Zhang, Tao; Ding, Shaohua; Duan, Suqing; Li, Yong

doi:10.1007/s00542-017-3384-y

Cited by 4 publications

(1 citation statement)

References 18 publications

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“…As a proof of concept, we first measured the absorbance of collected plasma to determine a minimum dilution factor and low haemolysis effect. We then did a blood type test using the extracted RBCs to ensure their characteristics were still well retained 29 , 30 . Moreover, we analysed the WBC seeding pattern in trapping units to confirm that efficient WBC trapping is possible.…”

Section: Introductionmentioning

confidence: 99%

A Microfluidic Device for Simultaneous Extraction of Plasma, Red Blood Cells, and On-Chip White Blood Cell Trapping

Kuan

et al. 2018

Sci Rep

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This study reports a microfluidic device for whole blood processing. The device uses the bifurcation law, cross-flow method, and hydrodynamic flow for simultaneous extraction of plasma, red blood cells, and on-chip white blood cell trapping. The results demonstrate successful plasma and red blood cell collection with a minimum dilution factor (0.76x) and low haemolysis effect. The extracted red blood cells can also be applied for blood type tests. Moreover, the device can trap up to ~1,800 white blood cells in 20 minutes. The three components can be collected simultaneously using only 6 μL of whole blood without any sample preparation processes. Based on these features, the microfluidic device enables low-cost, rapid, and efficient whole blood processing functionality that could potentially be applied for blood analysis in resource-limited environments or point-of-care settings.

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Section: Introductionmentioning

confidence: 99%