Microfluidic diffusion measurements: The optimal H-cell

Häusler, Erik B. G.; Domagalski, P.; Ottens, Marcel; Bardow, André

doi:10.1016/j.ces.2012.01.015

Cited by 22 publications

(27 citation statements)

References 20 publications

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“…For this reason, multiphysics studies of advection-diffusion in long channels typically use 2D analysis. For example, Hausler et al integrate out the variation of the velocity profile with channel depth, 26 and Lee et al solve the problem entirely in two dimensions. 27 The present study provides the first 3D multiphysics analysis of advection-diffusion at axial distances greater than 100 channel widths.…”

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confidence: 99%

Analysis of a laminar-flow diffusional mixer for directed self-assembly of liposomes

et al. 2012

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The present work describes the operation and simulation of a microfluidic laminarflow mixer. Diffusive mixing takes place between a core solution containing lipids in ethanol and a sheath solution containing aqueous buffer, leading to self assembly of liposomes. Present device architecture hydrodynamically focuses the lipid solution into a cylindrical core positioned at the center of a microfluidic channel of 125 Â 125-lm 2 cross-section. Use of the device produces liposomes in the size range of 100-300 nm, with larger liposomes forming at greater ionic strength in the sheath solution and at lower lipid concentration in the core solution. Finite element simulations compute the concentration distributions of solutes at axial distances of greater than 100 channel widths. These simulations reduce computation time and enable computation at long axial distances by utilizing long hexahedral elements in the axial flow region and fine tetrahedral elements in the hydrodynamic focusing region. Present meshing technique is generally useful for simulation of long microfluidic channels and is fully implementable using COMSOL Multiphysics. Confocal microscopy provides experimental validation of the simulations using fluorescent solutions containing fluorescein or enhanced green fluorescent protein.

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confidence: 99%

Analysis of a laminar-flow diffusional mixer for directed self-assembly of liposomes

et al. 2012

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“…Likewise, although 2D simulations assumed an infinitely deep channel, they produced identical solutions as the 3D model. Häusler et al, 11 who conducted diffusion coefficient measurements in microfluidic H-cell, has proposed a simplified mass balance equation with diffusion in the transverse direction only and convection in the moving direction, where the velocity was conducted as the average velocity on simplified rectangular cross-section. In general, the simplifications of fully developed 3D models are therefore acceptable, at least for homogeneous systems.…”

Section: Resultsmentioning

confidence: 99%

“…10 For measurements of diffusion coefficient in continuously operated microfluidic devices, the so called T-sensor and H-cell have received significant attention in recent years. 11,12 Diffusion coefficients within T-sensor were already successfully measured for small molecules and proteins ranging in mass from 800 Da to 66 kDa. 10,13 Culbertson et al 14 compared four methods employing the effects of the electric field within a microfluidic device, a static imaging method in the absence of electric field (i.e.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Diffusion Coefficient Determination using a Microfluidic Device

Miložič

Lubej

Novak

et al. 2014

Chem.Biochem.Eng.Q.

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A theoretical description of the convection-diffusion process in a homogeneous system enabling estimation of diffusion coefficients employing commercially available Y-junction microchannel is presented. A detailed numerical analysis based on finite volumes and finite differences, namely the explicit, implicit and Crank-Nicolson method, was performed and analyzed on the same domain in order to verify the proposed models. All numerical approaches provided stable solutions with certain numerical variations depending on the number of iterations defined by the mesh density. In addition, the method was validated with measurements of diffusion coefficients of some selected components in the short Y-junction microchannel. Benefits and possible pitfalls of this estimation method are discussed.

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“…1. The set-up works with a concept similar to an H-cell, which has been used for uid diusion measurements [5]. In the diusion cell, the chemicals will diuse from the Donor chamber, through a coating lm and into the Receiver chamber, where the concentration change is monitored using an ion selective probe.…”

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confidence: 99%

Diffusion cell investigations into the acidic degradation of organic coatings

et al. 2018

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Microfluidic diffusion measurements: The optimal H-cell

Cited by 22 publications

References 20 publications

Analysis of a laminar-flow diffusional mixer for directed self-assembly of liposomes

Analysis of a laminar-flow diffusional mixer for directed self-assembly of liposomes

Evaluation of Diffusion Coefficient Determination using a Microfluidic Device

Diffusion cell investigations into the acidic degradation of organic coatings

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