Microfluidic Devices as a Tool for Drug Delivery and Diagnosis: A Review

Sharma, I. B.; Thakur, Monika; Singh, Shaveta; Tripathi, Astha

doi:10.22159/ijap.2021v13i1.39032

Cited by 4 publications

(2 citation statements)

References 62 publications

(52 reference statements)

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“…Several reviews have described different microfluidic diagnostic and drug delivery systems (DDSs) discussing tumor models proposed for the characterization of delivery, efficacy, and toxicity of cancer nanomedicine, as well as the impact of the microfluidic device design and parameters on the type and properties of DDS formulations [235][236][237]. In general, whereas some systems focus on the investigation of how drugs behave when introduced into microfluidic tumor models, other systems concentrate on the creation of encapsulated or drugs prepared otherwise using microfluidics [238].…”

Section: Drug Development and Deliverymentioning

confidence: 99%

Application of Microfluidic Systems for Breast Cancer Research

et al. 2022

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Cancer is a disease in which cells in the body grow out of control; breast cancer is the most common cancer in women in the United States. Due to early screening and advancements in therapeutic interventions, deaths from breast cancer have declined over time, although breast cancer remains the second leading cause of cancer death among women. Most deaths are due to metastasis, as cancer cells from the primary tumor in the breast form secondary tumors in remote sites in distant organs. Over many years, the basic biological mechanisms of breast cancer initiation and progression, as well as the subsequent metastatic cascade, have been studied using cell cultures and animal models. These models, although extremely useful for delineating cellular mechanisms, are poor predictors of physiological responses, primarily due to lack of proper microenvironments. In the last decade, microfluidics has emerged as a technology that could lead to a paradigm shift in breast cancer research. With the introduction of the organ-on-a-chip concept, microfluidic-based systems have been developed to reconstitute the dominant functions of several organs. These systems enable the construction of 3D cellular co-cultures mimicking in vivo tissue-level microenvironments, including that of breast cancer. Several reviews have been presented focusing on breast cancer formation, growth and metastasis, including invasion, intravasation, and extravasation. In this review, realizing that breast cancer can recur decades following post-treatment disease-free survival, we expand the discussion to account for microfluidic applications in the important areas of breast cancer detection, dormancy, and therapeutic development. It appears that, in the future, the role of microfluidics will only increase in the effort to eradicate breast cancer.

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Section: Drug Development and Deliverymentioning

confidence: 99%

Application of Microfluidic Systems for Breast Cancer Research

et al. 2022

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“…Micromixers are essential for applications that require mixing of reagents to perform chemical or biochemical reactions on a micro scale [11]. However, the use of micromixers is not limited to chemistry and biochemistry, but is also used in drug delivery systems [12], DNA hybridization [13], nucleic acid sequencing [14], and polymerase chain reaction (PCR) [15]. Micromixers are generally divided into active and passive categories.…”

Section: Introductionmentioning

confidence: 99%

Numerical study of the performance of a bubble driven micromixer based on oscillating bubble injection

Rad

Mousavi

Kamali

2023

Preprint

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Micromixers are one of the common pieces of equipment in microﬂuidic devices and have been widely used for a variety of applications. They are generally divided into active and passive categories. Active micromixers use external energy sources for mixing. Pressure-based micromixers are a common type of active micromixer that use a variety of strategies to create disturbances in the ﬂow and improve mixing. Of all the strategies used for this type of micromixer, oscillating bubble injection has rarely been investigated. In this study, we investigate the ﬂow characteristics and mass transfer process in a two-dimensional micromixer based on oscillating bubble injection. Diﬀerent parameters aﬀect the mixing performance in this micromixer. In this study, the eﬀects of Reynolds number, bubble oscillation frequency, bubble oscillation amplitude, and side channel geometry on three variables of mixing index, pressure drop, and air inlet pressure have been investigated. The results show that with increasing Reynolds number at constant bubble oscillation frequency and amplitude, the mixing index decreases. Also, with increasing bubble oscillation frequency at constant Reynolds number and constant oscillation amplitude, the mixing index will increase. Increasing the bubble oscillation amplitude at constant Reynolds number and constant oscillation frequency will increase the mixing index. In a simple side channel with a constant diameter, the bubble becomes unstable, so this geometry is undesirable. Changing the side channel geometry by introducing an expansion in the side channel will solve this problem. Nevertheless, increasing the side channel expansion width will reduce the mixing index. The best mixing index was 78.19% in 4.5 seconds, and it shows that the proposed micromixer of this research has good performance in a relatively short time.

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