Microfluidic device for multilayer coating of magnetic microparticles

Hemptinne, A. de; Ziemecka, Iwona; Malsche, Wim De

doi:10.1016/j.powtec.2023.118223

Cited by 6 publications

(6 citation statements)

References 29 publications

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“…Equation 3 describes the forces acting on particles in stop flow condition. Following previous studies, in similar conditions, the time scale of the acceleration is much smaller than that of the translation (Reddy et al 1996 ; de Hemptinne et al 2022 , 2023b ). It allows neglecting inertial effects, i.e., the sum of the forces is zero.…”

Section: Introductionsupporting

confidence: 67%

Exploring operational boundaries for acoustic concentration of cell suspensions

de Hemptinne,

Gelin,

Bihi

et al. 2024

Appl Microbiol Biotechnol

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The development of a standardized, generic method for concentrating suspensions in continuous flow is challenging. In this study, we developed and tested a device capable of concentrating suspensions with an already high cell concentration to meet diverse industrial requirements. To address typical multitasking needs, we concentrated suspensions with high solid content under a variety of conditions. Cells from Saccharomyces cerevisiae, Escherichia coli, and Chinese hamster ovary cells were effectively focused in the center of the main channel of a microfluidic device using acoustophoresis. The main channel bifurcates into three outlets, allowing cells to exit through the central outlet, while the liquid evenly exits through all outlets. Consequently, the treatment separates cells from two-thirds of the surrounding liquid. We investigated the complex interactions between parameters. Increasing the channel depth results in a decrease in process efficiency, attributed to a decline in acoustic energy density. The study also revealed that different cell strains exhibit distinct acoustic contrast factors, originating from differences in dimensions, compressibility, and density values. Finally, a combination of high solid content and flow rate leads to an increase in diffusion through a phenomenon known as shear-induced diffusion. Key points • Acoustic focusing in a microchannel was used to concentrate cell suspensions • The parameters influencing focusing at high concentrations were studied • Three different cell strains were successfully concentrated Graphical abstract

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Section: Introductionsupporting

confidence: 67%

Exploring operational boundaries for acoustic concentration of cell suspensions

de Hemptinne,

Gelin,

Bihi

et al. 2024

Appl Microbiol Biotechnol

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“…The image is reproduced with permission from Ref. 51 , copyright 2023 Elsevier. (D) An electric field: the microfluidic electrospray is used to prepare alginate microspheres encapsulated celastrol.…”

Section: Shm Based On Embedded Obstacle Designmentioning

confidence: 99%

“…4. 51,52 Currently, abundant evidence from published research papers attests to the widespread use of microfluidics in constructing micro/nanoparticle DDSs. Leveraging specialized microchannel configurations, microfluidic methodologies are systematically displacing conventional approaches in the fabrication of micro/nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Research Strategies for Precise Manipulation of Micro/Nanoparticle Drug Delivery Systems Using Microfluidic Technology: A Review

Liu,

Fu,

et al. 2024

Pharmaceutical Fronts

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Microfluidic technology facilitates precise control over fluid mixing and interactions between the components, including self-assembly and precipitation. It offers new options for accurately manufacturing particles and holds significant potential in advancing micro/nanoparticle drug delivery systems (DDSs). Various microchannel/microfluidic chips have been explored to construct micro/nanoparticle DDSs. The precise manipulation of particle size, morphology, structure, stiffness, surface characteristics, and elasticity through microfluidic technology relies on specific microchannel geometrical designs and the application of exogenous energy, adhering to the principles of fluid motion. Consequently, this enables reproducible control over critical quality attributes (CQAs), such as particle size and distribution, encapsulation efficiency, drug loading, in vitro and in vivo drug delivery profiles, Zeta potential, and targeting capabilities, for micro/nanoparticle DDSs. In this review, we categorize microfluidic techniques and explore recent research developments in novel microchannel structures spanning the past 5 years (2018–2023) and their applications in micro/nanoparticle DDSs. Additionally, we elucidate the latest manipulation strategies of microfluidic techniques that impact foundational structures related to the CQAs of micro/nanoparticle DDSs. Furthermore, we offer insights into the industrial applications and challenges microfluidic techniques face in the context of novel micro/nanoparticle DDSs.

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“…15 Recent publication in field of magnetic microfluidics has reproduced this behavior but for four layers. 158 3.7. Filtration.…”

Section: Magnetic Separationmentioning

confidence: 99%

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

Rowland,

Aghakhani,

Whalley

et al. 2024

ACS Appl. Nano Mater.

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The deposition of thin films plays a crucial role in surface engineering, tailoring structural modifications, and functionalization across diverse applications. Layer-by-layer self-assembly, a prominent thin-film deposition method, has witnessed substantial growth since its mid-20th-century inception, driven by the discovery of eligible materials and innovative assembly technologies. Of these materials, micro-and nanoscopic substrates have received far less interest than their macroscopic counterparts; however, this is changing. The catalogue of eligible materials, including nanoparticles, quantum dots, polymers, proteins, cells and liposomes, along with some wellestablished layer-by-layer technologies, have combined to unlock impactful applications in biomedicine, as well as other areas like food fortification, and water remediation. To access these fields, several wellestablished technologies have been used, including tangential flow filtration, fluidized bed, atomization, electrophoretic assembly, and dielectrophoresis. Despite the invention of these technologies, the field of particle layer-by-layer still requires further technological development to achieve a high-yield, automatable, and industrially ready process, a requirement for the diverse, reactionary field of biomedicine and high-throughput pharmaceutical industry. This review provides a background on layer-by-layer, focusing on how its constituent building blocks and bonding mechanisms enable unmatched versatility. The discussion then extends to established and recent technologies employed for coating micro-and nanoscopic matter, evaluating their drawbacks and advantages, and highlighting promising areas in microfluidic approaches, where one distinctly auspicious technology emerges, acoustofluidics. The review also explores the potential and demonstrated application of acoustofluidics in layer-by-layer technology, as well as analyzing existing acoustofluidic technologies beyond LbL coating in areas such as cell trapping, cell sorting, and multidimensional particle manipulation. Finally, the review concludes with future perspectives on layer-by-layer nanoparticle coating and the potential impact of integrating acoustofluidic methods.

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Microfluidic device for multilayer coating of magnetic microparticles

Cited by 6 publications

References 29 publications

Exploring operational boundaries for acoustic concentration of cell suspensions

Exploring operational boundaries for acoustic concentration of cell suspensions

Research Strategies for Precise Manipulation of Micro/Nanoparticle Drug Delivery Systems Using Microfluidic Technology: A Review

Layer-by-Layer Nanoparticle Assembly for Biomedicine: Mechanisms, Technologies, and Advancement via Acoustofluidics

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