Microfluidic Based Biosensors as Point of Care Devices for Infectious Diseases Management

Sri, Smriti; Dhand, Chetna; Rathee, Jyotsna; Ramakrishna, Seeram; Solanki, Pratima R.

doi:10.1166/sl.2019.3976

Cited by 17 publications

(13 citation statements)

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“…Infectious diseases are usually identified by bacteria (e.g., Streptococcus agalactiae, Escherichia coli, Haemophilus influenza), food borne pathogens (e.g., salmonella, listeria, cholera toxin), and viruses (e.g., hepatitis C, influenza, dengue virus). 204 For example, shear horizontal surface acoustic wave biosensors were established for multiplex detection of anti-p24 and anti-gp41 antibodies of HIV. 205 The designed dual-channel biochip consists of a sensing area sensitive to biological binding events, along with in situ reference control coating and miniaturization configuration.…”

Section: Microfluidic Biosensors For Pandemicsmentioning

confidence: 99%

Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19

et al. 2020

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Biosensors and nanoscale analytical tools have shown huge growth in literature in the past 20 years, with a large number of reports on the topic of 'ultrasensitive', 'cost-effective', and 'early detection' tools with a potential of 'massproduction' cited on the web of science. Yet none of these tools are commercially available in the market or practically viable for mass production and use in pandemic diseases such as coronavirus disease 2019 . In this context, we review the technological challenges and opportunities of current bio/chemical sensors and analytical tools by critically analyzing the bottlenecks which have hindered the implementation of advanced sensing technologies in pandemic diseases. We also describe in brief COVID-19 by comparing it with other pandemic strains such as that of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) for the identification of features that enable biosensing. Moreover, we discuss visualization and characterization tools that can potentially be used not only for sensing applications but also to assist in speeding up the drug discovery and vaccine development process. Furthermore, we discuss the emerging monitoring mechanism, namely wastewater-based epidemiology, for early warning of the outbreak, focusing on sensors for rapid and on-site analysis of SARS-CoV2 in sewage. To conclude, we provide holistic insights into challenges associated with the quick translation of sensing technologies, policies, ethical issues, technology adoption, and an overall outlook of the role of the sensing technologies in pandemics.

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Section: Microfluidic Biosensors For Pandemicsmentioning

confidence: 99%

Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19

et al. 2020

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“…In general, most of the chip-based biosensors for nucleic acid testing are made of glass because of its transparency and low auto-fluorescence [129][130][131]. However, temperature distribution is not uniform due to the low thermal conductivity of glass.…”

Section: Chip-based Poc Biosensors For the Detection Of Nucleic Acidsmentioning

confidence: 99%

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Rasmi

Khan

et al. 2021

Anal Bioanal Chem

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Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections.

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“… 80 , 81 Several microfluidic biosensors have been developed and exploited for the detection of various infectious agents such as bacterial pathogens (e.g., Streptococcus , E. coli , Haemophilus influenza ), foodborne pathogens (e.g., Salmonella , Listeria , Cholera toxin), and viral pathogens (e.g., Hepatitis C, influenza, and dengue virus). 82 However, for detection of COVID-19 using microfluidic platform only a few attempts have been made so far. For instance, Lin et al developed the quick multiplexed detection of IgG, IgM antibodies, and antigen of SARS-CoV-2 simultaneously in a single microfluidics chip.…”

Section: Microfluidic Integrated Technique-based Biosensorsmentioning

confidence: 99%

Point-of-Care Biosensor-Based Diagnosis of COVID-19 Holds Promise to Combat Current and Future Pandemics

Parihar

Ranjan

Sanghi

et al. 2020

ACS Appl. Bio Mater.

138

107

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Efficient and rapid detection of viruses plays an extremely important role in disease prevention, diagnosis, and environmental monitoring. Early screening of viral infection among the population has the potential to combat the spread of infection. However, the traditional methods of virus detection being used currently, such as plate culturing and quantitative RT-PCR, give promising results, but they are time-consuming and require expert analysis and costly equipment and reagents; therefore, they are not affordable by people in low socio-economic groups in developing countries. Further, mass or bulk testing chosen by many governments to tackle the pandemic situation has led to severe shortages of testing kits and reagents and hence are affecting the demand and supply chain drastically. We tried to include all the reported current scenario-based biosensors such as electrochemical, optical, and microfluidics, which have the potential to replace mainstream diagnostic methods and therefore could pave the way to combat COVID-19. Apart from this, we have also provided information on commercially available biosensors for detection of SARS-CoV-2 along with the challenges in development of better diagnostic approaches. It is therefore expected that the content of this review will help researchers to design and develop more sensitive advanced commercial biosensor devices for early diagnosis of viral infection, which can open up avenues for better and more specific therapeutic outcomes.

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Microfluidic Based Biosensors as Point of Care Devices for Infectious Diseases Management

Cited by 17 publications

References 0 publications

Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19

Opportunities and Challenges for Biosensors and Nanoscale Analytical Tools for Pandemics: COVID-19

Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Point-of-Care Biosensor-Based Diagnosis of COVID-19 Holds Promise to Combat Current and Future Pandemics

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