Microfluidic-Assisted Fabrication of Flexible and Location Traceable Organo-Motor

Abstract

In this paper, we fabricate a flexible and location traceable micromotor, called organo-motor, assisted by microfluidic devices and with high throughput. The organo-motors are composed of organic hydrogel material, poly (ethylene glycol) diacrylate (PEGDA), which can provide the flexibility of their structure. For spatial and temporal traceability of the organo-motors under magnetic resonance imaging (MRI), superparamagnetic iron oxide nanoparticles (SPION; Fe3O4) were incorporated into the PEGDA microhydrogels. Furthermore, a thin layer of platinum (Pt) was deposited onto one side of the SPION-PEGDA microhydrogels providing geometrical asymmetry and catalytic propulsion in aqueous fluids containing hydrogen peroxide solution, H2O2. Furthermore, the motion of the organo-motor was controlled by a small external magnet enabled by the presence of SPION in the motor architecture.

Highly Efficient Thermoresponsive Nanocomposite for Controlled Release Applications

“…combined microfluidic and centrifugation-re-dispersion technologies to form core/shell photonic crystal microbeads by using an assembly made of PNIPAM and polystyrene nanoparticles for optical encoding applications. Seo et al 32. incorporated magnetic nanoparticles in hydrogel microparticles to fabricate flexible and location traceable organo-motor.…”

“…Seo et al . 32 incorporated magnetic nanoparticles in hydrogel microparticles to fabricate flexible and location traceable organo-motor. Also, Wei et al .…”

MRI-based communication for untethered intelligent medical microrobots

“…For instance, Eq. (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19) shows the relationship between the total acquisition time, rBW and matrix size.…”

“…However, the great majority of the studies on microrobots for interventions in the human body focus on the actuation and control of the microrobots [5][6][7][8][9][10][11][12][13][14]. Potential applications of the microrobots can be considerably expanded by embedding an integrated circuit capable of sensing, processing, and communicating environmental variables (e.g., pH, O2).…”

Synthesis of Poly(<em>N</em>-isopropylacrylamide) Janus Microhydrogels for Anisotropic Thermo-responsiveness and Organophilic/Hydrophilic Loading Capability

“…25,26 The microfluidic approach is at the forefront of research as a means of fabricating micro-sized particles with narrow size distributions and complex shapes. [27][28][29][30][31] The advantages of fabricating microparticles in the microfluidic device are predicated by the small characteristic length of the microfluidic device, which results in a low Reynolds number. In contrast to traditional bulk emulsification where drops are formed in parallel, microdroplets produced in microfluidic devices are generated in series and subsequently polymerized into microparticles upon exposure to UV irradiation.…”