Microfluidic aspects of adhesive microbial dynamics: A numerical exploration of flow-cell geometry, Brownian dynamics, and sticky boundaries

Bonilla, F. Alejandro; Kleinfelter, Natalie; Cushman, John H.

doi:10.1016/j.advwatres.2006.05.028

Cited by 7 publications

(3 citation statements)

References 41 publications

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“…Bonilla et al [1] present a numerical analysis of microbial transport and adhesion at the pore scale using Brownian dynamical simulations, where adhesion to the solid surfaces represented as a random process. The focus of this work is both to present a description of how such numerical models can be constructed, as well as to provide some practical feedback as to how this information can be used in designing experimental flowcells for studying microbial adhesion and transport.…”

Section: Upscaling Theory Development and Numerical Methodsmentioning

confidence: 99%

“…A particular focus of the issue is on establishing connections between the cell scale and the scale of observations that are typically made in applications. As such, papers for this special issue were sought that either (1) investigated biological phenomena at a single length scale using new or novel methods, or (2) explicitly accounted for the multiscale manifestation of biological processes in porous media, either experimentally or theoretically. A particular effort was made to building a cohesive issue that attempts to logically connect the most fundamental scales of research with those that are observed in applications.We feel that the papers that are collected in this issue accomplish this goal.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Biological processes in porous media: From the pore scale to the field

Wood¹,

Ford²

2007

Advances in Water Resources

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Section: Upscaling Theory Development and Numerical Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Biological processes in porous media: From the pore scale to the field

Wood¹,

Ford²

2007

Advances in Water Resources

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“…We note that our framework can be applied in random particle systems that interact with each other based on their order (see [18][19][20][21]), risk-controlled quadratic optimization problems (see, [22]), and sticky microbial dynamics (see, [23][24][25]), amongst others. We leave a more detailed account of these applications for future and focus on establishing the mathematical groundwork in this paper.…”

Section: Introductionmentioning

confidence: 99%

On a family of coupled diffusions that can never change their initial order

Mengütürk¹,

Mengütürk²

2022

J. Phys. A: Math. Theor.

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We introduce a real-valued family of interacting diﬀusions where their paths can meet but cannot cross each other in a way that would alter their initial order. Any given interacting pair is a solution to coupled stochastic diﬀerential equations with time-dependent coeﬃcients satisfying certain regularity conditions with respect to each other. These coeﬃcients explicitly determine whether these processes bounce away from each other or stick to one another if/when their paths collide. When all interacting diﬀusions in the system follow a martingale behaviour, and if all these paths ultimately come into collision, we show that the system reaches a random steady-state with zero ﬂuctuation thereafter. We prove that in a special case when certain paths abide to a deterministic trend, the system reduces down to the topology of captive diﬀusions. We also show that square-root diﬀusions form a subclass of the proposed family of processes. Applications include order-driven interacting particle systems in physics, adhesive microbial dynamics in biology and risk-bounded quadratic optimization solutions in control theory.

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Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms

Lee

Kaplan

Lee

2008

Biomed Microdevices

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Microfluidic devices were used to study the influences of hydrodynamics of local microenvironments on Staphylococcus epidermidis (S. epidermidis) biofilm formation and the effects of a poly(beta-1,6-N-acetyl glucosamine)-hydrolyzing enzyme (dispersin B) and/or an antibiotic (rifampicin) on the detachment of the biofilm. Elongated, monolayered biofilm morphologies were observed at high flow velocity and fluid shear locations whereas large clump-like, multilayered biofilm structures were produced at low flow velocity and fluid shear locations. Upon dispersin B treatment, most of the biofilm was detached from the microchannel surface. However, a trace amount of bacterial cells could not be removed from corner locations most likely due to the insufficient wall shear stress of the fluid at these locations. Dispersin B or rifampicin treatment was effective in delaying the dispersal behavior of bacterial cells, but could not completely remove the biofilm. Combined dynamic delivery of dispersin B and rifampicin was found to be effective for complete removal of the S. epidermidis biofilm.

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Microfluidic aspects of adhesive microbial dynamics: A numerical exploration of flow-cell geometry, Brownian dynamics, and sticky boundaries

Cited by 7 publications

References 41 publications

Biological processes in porous media: From the pore scale to the field

Biological processes in porous media: From the pore scale to the field

On a family of coupled diffusions that can never change their initial order

Microfluidic devices for studying growth and detachment of Staphylococcus epidermidis biofilms

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