Microflow, Sequential Coupling and Cyclization Approach for Synthesis of Cyclic Phosphotriesters from PCl3
Kohei Nakabayashi,
Hiroshi Kitamura,
Shinichiro Fuse
Abstract:An approach for the synthesis of cyclic phosphotriesters with various ring sizes (5‐ to 8‐membered rings) from phosphorus trichloride and diols was developed. The major challenge in developing this approach is the suppression of the undesired reactions caused by substrates containing multiple highly reactive sites. These undesired reactions were successfully suppressed by microflow technology, which can precisely control the reaction time and temperature. Two optimal conditions were developed, depending on the… Show more
We report the first switchable acylation of H-phosphonate with chloroformate in microflow reactors. The acylation site (P vs. O) in H-phosphonate was switched by changing the acyl pyridinium/ammonium ions.
We report the first switchable acylation of H-phosphonate with chloroformate in microflow reactors. The acylation site (P vs. O) in H-phosphonate was switched by changing the acyl pyridinium/ammonium ions.
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