Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomy

Domellöf, L; Reddy, Bandaru S.; Weisburger, John H.

doi:10.1016/0002-9610(80)90024-0

Cited by 101 publications

(36 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In remnant stomachs, carcinogenesis involving bile juice is thought to be related to the altered environment caused by the operation. Several reports, for example, have referred to the involvement of pH above 4.0 [58] or the presence of bacterial flora and unconjugated bile acids in the gastric juice [59,60].…”

Section: Mucosal Injury and Cell Proliferation Induced By Bile Juicementioning

confidence: 99%

Duodenogastric reflux and gastric stump carcinoma

Kondo

2002

Gastric Cancer

View full text Add to dashboard Cite

Section: Mucosal Injury and Cell Proliferation Induced By Bile Juicementioning

confidence: 99%

Duodenogastric reflux and gastric stump carcinoma

Kondo

2002

Gastric Cancer

View full text Add to dashboard Cite

“…Many reports have studied the pathogenesis and causes of gastric remnant cancer [5][6][7][8][9][10], but there is little information available on molecular biological analyses to identify individuals susceptible to gastric remnant cancer.…”

Section: Introductionmentioning

confidence: 99%

Microsatellite instability in patients with gastric remnant cancer

et al. 1999

View full text Add to dashboard Cite

“…Conjugated bile acids are soluble at acidic pH. Deconjugation of these acids, however, frequently occurs in the gastrointestinal tract under the action of certain bacteria (Domellof et al, 1980). Upon deconjugation, these bile acids can damage the small intestinal villi (Holt, 1966) and may inhibit the transport of amino acids, sodium and glucose across the jejunal mucosa (Clark et al, 1969;Popesco et al, 1966).…”

Section: Pathophysiology Of Bile Induced Injurymentioning

confidence: 99%

Review Article; Duodeno-Gastro-Esophageal Reflux Combined and Isolated

Nasr¹

2013

American Medical Journal

View full text Add to dashboard Cite

Barrett's esophagus is the chief risk factor for esophageal adenocarcinoma. Reflux of gastric acid has long been related to the development of esophagitis and Barrett's esophagus, but the role of duodenal contents is controversial. We review the literature on the role of duodenal contents in the development of esophagitis, Barrett's esophagus and adenocarcinoma in addition to the role of acid suppressant therapy in the development or prevention of these changes. A computer-based search of the literature using the terms "Bilirubin, Barrett, Bile Reflux, duodeno-gastric reflux and oesophagus/esophagus" was performed. The role of bile and other constituents of duodenal refluxate were examined. Techniques for identifying nonacid reflux were also reviewed, as were the role of pH, medication and surgery in modulating disease severity. Complicated Barrett's esophagus is associated with increased exposure to gastric and duodenal refluxate. Biological effect of bile acids depends on the conjugation status, the pH of the milieu and the pKa of bile acids. While Proton Pump Inhibitors reduce the levels of DGER, they also produce changes in gastric and lower esophageal pH that activate different bile acids at different pH levels resulting in unexpected injury. Conjugated bile acids are harmful in acidic environment while unconjugated bile acids are harmful at neutral pH environment. An overlap of toxicity among conjugated and unconjugated bile acids occurs between strongly acidic and neutral pH levels. Normalisation of gastric and duodenal refluxate should ideally be the goal of treatment.

show abstract

Microflora and deconjugation of bile acids in alkaline reflux after partial gastrectomy

Cited by 101 publications

References 28 publications

Duodenogastric reflux and gastric stump carcinoma

Duodenogastric reflux and gastric stump carcinoma

Microsatellite instability in patients with gastric remnant cancer

Review Article; Duodeno-Gastro-Esophageal Reflux Combined and Isolated

Contact Info

Product

Resources

About