Microfibrillated cellulose films containing chitosan and tannic acid for wound healing applications

Abstract

The effectiveness of tannic acid as antimicrobial and wound healing for burns have been shown for a century; however, uncontrolled target dosage may result in undesirable side-effects. Remarkably, tannic acid polyphenols compounds crosslinked with polymeric materials produce a strong composite containing the beneficial properties of this tannin. However, investigation of the crosslink structure and its antibacterial and regenerative properties are still unknown when using nanocellulose by mechanical defibrillation; additionally, due to the potential crosslink structure with chitosan, its structure can be complex. Therefore, this work uses bleach kraft nanocellulose in order to investigate the effect on the physical and regenerative properties when incorporated with chitosan and tannic acid. This film results in increased rigidity with a lamellar structure when incorporated with tannic acid due to its strong hydrogen bonding. The release of tannic acid varied depending on the structure it was synthesised with, whereas with chitosan it presented good release model compared to pure cellulose. In addition, exhibiting similar thermal stability as pure cellulose films with antibacterial properties tested against S. aureus and E. coli with good metabolic cellular viability while also inhibiting NF-κB activity, a characteristic of tannic acid.

Properties enhancement of chitosan‐filled polylactic acid biocomposites using tannic acid treatment

“…Meanwhile, the ether bond (2) was formed as a result of interaction between the hydroxyl group of Cs and TA, respectively, which was proven by the reduction in C O C peak intensity at 1065-1022 cm À1 . This was line with a study reported by Aliabadi et al 44 who found a large alteration at the 1737-1671 cm À1 and 1043-1030 cm À1 regions, when TA was incorporated into the microfibrillated cellulose/Cs films.…”

An agar–polyvinyl alcohol hydrogel loaded with tannic acid with efficient hemostatic and antibacterial capacity for wound dressing

“…25 Moreover, TA showed good antibacterial ability and strong bactericidal effect against Staphylococcus aureus and Escherichia coli. 28,29 Meanwhile, TA can inhibit the production of NO by stimulated macrophages and exhibits good anti-inflammatory activity. 30 In this study, we chose a hydrogel system of agar and polyvinyl alcohol (PVA).…”

Towards biodegradable barrier packaging: Production of films for single-use primary food liquid packaging

“…The MFC load is reduced when a plasticizer is added. This reduces the mechanical reinforcement, a behavior observed in previous MFC and polyols antibacterial films (Liu et al 2013;Aliabadi et al 2021). Opposite results (an increase in the TI) were obtained for cellulose nanocrystals (CNC) with the addition of mannitol, sorbitol, and glycerol.…”