Microfabrication, Microstructures and Microsystems

Qin, Dong; Xia, Younan; Rogers, John A.; Jackman, Rebecca J.; Zhao, Xiaomei; Whitesides, George M.

doi:10.1007/3-540-69544-3_1

Cited by 135 publications

(98 citation statements)

References 124 publications

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“…Most methods for 3D microfabrication are based on photolithography (30,64). A number of techniques (some very clever but none very simple or easily extended to the parallel fabrication of very large numbers of components) have been used to convert 100-m-scale two-dimensional structures produced by photolithography into 3D structures (65)(66)(67)(68). The most versatile of these at present seems to be self-folding, which is another form of self-assembly.…”

Section: Components For Self-assemblymentioning

confidence: 99%

Beyond molecules: Self-assembly of mesoscopic and macroscopic components

Whitesides

Boncheva²

2002

Proc. Natl. Acad. Sci. U.S.A.

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Self-assembly is a process in which components, either separate or linked, spontaneously form ordered aggregates. Self-assembly can occur with components having sizes from the molecular to the macroscopic, provided that appropriate conditions are met. Although much of the work in self-assembly has focused on molecular components, many of the most interesting applications of self-assembling processes can be found at larger sizes (nanometers to micrometers). These larger systems also offer a level of control over the characteristics of the components and over the interactions among them that makes fundamental investigations especially tractable.

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Section: Components For Self-assemblymentioning

confidence: 99%

Beyond molecules: Self-assembly of mesoscopic and macroscopic components

Whitesides

Boncheva²

2002

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

1,440

1,045

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“…Our approach to the fabrication of microfluidic devices is based primarily on the techniques of soft lithography [2,46,47], specifically rapid prototyping and replica molding. Soft lithography is a suite of nonphotolithographic methods for replicating a pattern.…”

Section: Soft Lithographymentioning

confidence: 99%

Fabrication of microfluidic systems in poly(dimethylsiloxane)

et al. 2000

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Microfluidic devices are finding increasing application as analytical systems, biomedical devices, tools for chemistry and biochemistry, and systems for fundamental research. Conventional methods of fabricating microfluidic devices have centered on etching in glass and silicon. Fabrication of microfluidic devices in poly(dimethylsiloxane) (PDMS) by soft lithography provides faster, less expensive routes than these conventional methods to devices that handle aqueous solutions. These soft‐lithographic methods are based on rapid prototyping and replica molding and are more accessible to chemists and biologists working under benchtop conditions than are the microelectronics‐derived methods because, in soft lithography, devices do not need to be fabricated in a cleanroom. This paper describes devices fabricated in PDMS for separations, patterning of biological and nonbiological material, and components for integrated systems.

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“…Microfabrication of increasingly complex separation devices on chips that are ever smaller is currently revolutionizing the area of chemical and biological analysis [1,2]. Analytical microchips are expected to allow substantial miniaturization and acceleration of a wide variety of analytical procedures, facilitating their combinations, and eventually leading to efficient ªmicro total analytical systemsº (mTAS) [3].…”

Section: Introductionmentioning

confidence: 99%

Towards stationary phases for chromatography on a microchip: Molded porous polymer monoliths prepared in capillaries by photoinitiatedin situ polymerization as separation media for electrochromatography

2000

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Photoinitiated free radical polymerization has been used for the preparation of porous polymer monoliths within UV transparent fused silica capillaries and quartz tubes. These formats were used as models for the preparation of the separation media within channels of microfabricated devices. A mixture of ethylene dimethacrylate, butyl methacrylate, and 2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid was polymerized in the presence of a porogenic solvent consisting of 1‐propanol, 1,4‐butanediol, and water at room temperature under UV irradiation. Modification of the porogen composition enables the tailoring of pore size within the broad range from ca. 100 to 4000 nm. Scanning electron micrographs confirmed the homogeneity of the porous structure of the materials prepared, even in a quartz tube with a diameter as large as 4 mm. Separation properties of the resulting capillary columns were tested in capillary electrochromatography (CEC) mode using a mixture of thiourea and eight aromatic compounds. Plate number as high as 210 000 plates/m were found for a capillary column with optimized porous properties. The monolithic columns were also able to separate mixtures of peptides.

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Microfabrication, Microstructures and Microsystems

Cited by 135 publications

References 124 publications

Beyond molecules: Self-assembly of mesoscopic and macroscopic components

Beyond molecules: Self-assembly of mesoscopic and macroscopic components

Fabrication of microfluidic systems in poly(dimethylsiloxane)

Towards stationary phases for chromatography on a microchip: Molded porous polymer monoliths prepared in capillaries by photoinitiatedin situ polymerization as separation media for electrochromatography

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