Microfabrication for Drug Delivery

Koch, Brendan; Rubino, Ilaria; Quan, Fu‐Shi; Yoo, Bongyoung; Choi, Hyo-Jick

doi:10.3390/ma9080646

Cited by 29 publications

(13 citation statements)

References 187 publications

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“…Koch presents injection molded microneedle arrays for disposable applications which enable mass production. Figure shows the SEM micrograph of the injection molded micro needles.…”

Section: Discussionmentioning

confidence: 99%

A review on microfabrication of thermoplastic polymer‐based microneedle arrays

Aar

Brouwer

2019

Polymer Engineering & Sci

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This article will provide an overview of recent developments for microneedles made using injection molding and hot embossing techniques for active transdermal drug delivery. Microneedle arrays are developed for pain‐free and efficient drug delivery without using a cold chain. The focus of this article will be on the use of engineering thermoplastics and microneedle manufacturing techniques including patterning. Recent developments demonstrate that commercialization of polymer‐based microneedle systems is feasible. POLYM. ENG. SCI., 59:877–890, 2019. © 2019 Society of Plastics Engineers

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“…Koch presents injection molded microneedle arrays for disposable applications which enable mass production. Figure shows the SEM micrograph of the injection molded micro needles.…”

Section: Discussionmentioning

confidence: 99%

A review on microfabrication of thermoplastic polymer‐based microneedle arrays

Aar

Brouwer

2019

Polymer Engineering & Sci

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“…Topical drug delivery is another method to oral medication if there cause poisoning it can be removed easily, this topical administration is useful for the self-administration so that the cost of the treatment will be reduced the disadvantages of this topical application is skin itching, contact dermatitis because the preparation contains hydrophilic molecule mainly in emulsion formulation 48 . Other preparation such as liposome, noisome, ethosomes, lipid carriers are more useful in the treatment of the topical application as antipsoriatic drugs, these nanoemulsions are well characterized and promising topical drug delivery for the patient with psoriasis.…”

Section: Novel Colloidal Drug Delivery System For Skinmentioning

confidence: 99%

Untitled

2020

IJPSR

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Nanoemulsion system is a promising vehicle due to the powerful ability to deliver the drug through the skin. Researchers have been conducted to prove its potential for the delivery of the drugs used in many skin disorders. Skin is the largest organ and acts as the first line of defense of our body. After a certain period of time, our skin loses tone and elasticity which is called aging. It is the result of programmed senescence and prolonged environmental injury to the skin. The aim of this review article is to provide information regarding the control of skin aging by the nanoemulsion drug delivery system. Novel carrier systems have a lot of advantages when compared to conventional formulations. There are various approaches to preventing skin aging. The most widely used age combating substances in cosmeceuticals are kinetin, Retinoids, sun filters, herbal ingredients (such as resveratrol, turmeric, and green tea), and antioxidants (such as alpha-tocopherol, ascorbic acid, coenzyme Q10 and lipoic acid). In recent years, these molecules have been formulated as nanosized carriers such as vesicular systems, Therefore, nanocarrier such as liposomes, noisome, microemulsions and nanoparticles have been widely investigated as delivery systems for antioxidants to improve their beneficial effects in the treatment of skin aging. In this review, an overview of cosmetic, product-oriented solutions for skin aging is given and different approaches to combat aging are summarized. This review discusses the role of oxidative events of tissue degeneration and aging in general, and for the skin in particular. The mechanisms involved in intrinsic and extrinsic (photo-) aging are described. To prevent or treat skin aging, topical supplementation with antioxidants is regarded as one of the most promising strategies. Overall review says that antioxidants are most commonly used in anti-aging cosmetic products will be reviewed along with the nanocarrier designed to improve their safety and effectiveness. INTRODUCTION: Nanoemulsion is a type of emulsion which is very fine and metastable in nature, the size of the droplets is smaller than the 100 nanometres. Based on the process used for the preparation of nanoemulsion their structure is identified.

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“…[112,113] The use of microfabrication techniques allows for the accurate control over devices' surface microarchitecture, topography, and feature size, which play an important role in the device fabrication and function accomplishment.…”

Section: Fabrication Technologiesmentioning

confidence: 99%

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Microfabrication for Drug Delivery

Cited by 29 publications

References 187 publications

A review on microfabrication of thermoplastic polymer‐based microneedle arrays

A review on microfabrication of thermoplastic polymer‐based microneedle arrays

Untitled

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

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