Microfabricated microfluidic platforms for creating microlens array

Chen, Pin-Chuan; Chang, Yi‐Pin; Zhang, Ren-Hao; Wu, Chun‐Chieh; Tang, Geo-Ry

doi:10.1364/oe.25.016101

Cited by 17 publications

(7 citation statements)

References 31 publications

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“…PDMS casting was then used to create a nonplanar PDMS membrane ( Figure 5 d). Heterogeneous solvent bonding was used to bond the PDMS membrane on a hemispherical PMMA shell ( Figure 5 e) for use in a nonplanar microlens array (MLA) ( Figure 5 f) [ 23 ].…”

Section: Extended Nonplanar Fabrication Process For Pdms/pmma Chipmentioning

confidence: 99%

“…The system included a sensor (PS100-10 Bar, Yalab, Taipei, Taiwan) to measure pressure within the microchannel, a manual syringe pump to push liquid into the microfluidic chip and to deform the PDMS membrane, and a microscope to record the deformation of the PDMS ( Figure 8 b). The key parameters to control the MLS was described in the previous article [ 23 ], and the diameter of each MLA in Figure 7 a is 2 mm.…”

Section: Extended Nonplanar Fabrication Process For Pdms/pmma Chipmentioning

confidence: 99%

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Microfabrication of Nonplanar Polymeric Microfluidics

2018

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For four decades, microfluidics technology has been used in exciting, state-of-the-art applications. This paper reports on a novel fabrication approach in which micromachining is used to create nonplanar, three-dimensional microfluidic chips for experiments. Several parameters of micromachining were examined to enhance the smoothness and definition of surface contours in the nonplanar poly(methyl methacrylate) (PMMA) mold inserts. A nonplanar PMMA/PMMA chip and a nonplanar polydimethylsiloxane (PDMS)/PMMA chip were fabricated to demonstrate the efficacy of the proposed approach. In the first case, a S-shape microchannel was fabricated on the nonplanar PMMA substrate and sealed with another nonplanar PMMA via solvent bonding. In the second case, a PDMS membrane was casted from two nonplanar PMMA substrates and bonded on hemispherical PMMA substrate via solvent bonding for use as a microlens array (MLAs). These examples demonstrate the effectiveness of micromachining in the fabrication of nonplanar microfluidic chips directly on a polymeric substrate, as well as in the manufacture of nonplanar mold inserts for use in creating PDMS/PMMA microfluidic chips. This technique facilitates the creation of nonplanar microfluidic chips for applications requiring a three-dimensional space for in vitro characterization.

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Section: Extended Nonplanar Fabrication Process For Pdms/pmma Chipmentioning

confidence: 99%

Section: Extended Nonplanar Fabrication Process For Pdms/pmma Chipmentioning

confidence: 99%

Microfabrication of Nonplanar Polymeric Microfluidics

2018

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“…Recently, the microfluidic manipulation technique has become a new candidate for fashioning optical lenses. In the fabrication of the MLA using the microfluidic manipulation technique, the curvature of the lenslets can be well controlled by harnessing surface tension or applying pressure to reshape the profile of microfluid in the mold [ 23 , 24 , 25 , 26 ]. Based on the characteristics of microfluidic technology, Long et al proposed the preparation of multi-focus MLA with uniform aperture on curved microfluidics with inclined sidewalls.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Multifocal Microlens Array by One Step Exposure Process

Wei

Cai

et al. 2021

Micromachines

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Microlenses can be widely used in integrated micro-optical systems. However, in some special applications, such as light field imaging systems, multifocal microlens arrays (MLA) are expected to improve imaging resolution. For the fabrication of multifocal MLA, the traditional fabrication method is no longer applicable. To solve this problem, a fabrication method of multifocal MLA by a one step exposure process is proposed. Through the analyses and research of photoresist AZ9260, the nonlinear relationship between exposure dose and exposure depth is established. In the design of the mask, the mask pattern is corrected according to the nonlinear relationship to obtain the final mask. The continuous surface of the multifocal MLA is fabricated by the mask moving exposure. The experimental results show that the prepared multifocal MLA has high filling factor and surface fidelity. What is more, this method is simple and efficient to use in practical applications.

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“…Based on this solvent bonding method, we can create hybrid ABS/PMMA microfluidic chips which provide a number of side benefits: (1) connectors can be embedded during 3D printing to eliminate the troublesome task of assembling tubing during the execution of experiments; and (2) channels on the PMMA side can be fabricated at micro/sub-micro/nanoscales without having to deal with current limitations pertaining to 3D printing resolution. [21][22][23][24][25] To demonstrate the benefits of the proposed bonding technique, two microfluidic devices were then fabricated: (a) a 3D SAR-based passive micromixer and (b) an integrated chip with a micro mixing system and double-emulsion generator.…”

Section: Introductionmentioning

confidence: 99%

Simple and low-cost production of hybrid 3D-printed microfluidic devices

Duong

Chen

2019

Biomicrofluidics

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The use of three-dimensional (3D) printing for the fabrication of microfluidic chips has attracted considerable attention among researchers. This low-cost fabrication method allows for rapid prototyping and the creation of complex structures; however, these devices lack optical transparency, which greatly hinders the characterization and quantification of experiment results. To address this problem, integrating a transparent substrate with a 3D-printed chip is an effective approach. In this study, we present a solvent bonding method of poly(methyl methacrylate) (PMMA) and acrylonitrile butadiene styrene (ABS) thermoplastic materials for the creation of optically detectable 3D-printed microfluidic devices. To achieve an excellent bonding between PMMA and ABS substrates, we used spray coating as a method for the distribution of ethanol solution followed by UV exposure and post-annealing step to improve the bonding strength. We fabricated a microfluidic chip with S-microchannel to characterize the bonding protocol, and other two application-oriented microfluidic chips, including a 3D split-and-recombine-based passive micromixer, and an integrated microchip for the mixing of two streams of liquid prior to the formation of double-emulsion droplets, to evaluate the efficacy of the proposed scheme. As a result, at least eight bars of the bonding strength between PMMA/ABS substrates was achieved, and the ability of producing optically detectable 3D-printed microfluidic devices based on this bonding method was confirmed.

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Microfabricated microfluidic platforms for creating microlens array

Cited by 17 publications

References 31 publications

Microfabrication of Nonplanar Polymeric Microfluidics

Microfabrication of Nonplanar Polymeric Microfluidics

Fabrication of Multifocal Microlens Array by One Step Exposure Process

Simple and low-cost production of hybrid 3D-printed microfluidic devices

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