Microfabricated acoustofluidic membrane acoustic waveguide actuator for highly localized in-droplet dynamic particle manipulation

Abstract

Precision manipulation techniques in microfluidics often rely on ultrasonic actuators to generate displacement and pressure fields in a liquid. However, strategies to enhance and confine the acoustofluidic forces often work...

Cavity-Agnostic Acoustofluidic Functions Enabled by Guided Flexural Waves on a Membrane Acoustic Waveguide Actuator

“…These traps are formed by constructive interference between the waves coming from the opposite sides of the membrane waveguide. As Vachon et al [70] explained, different propagation and interference modes may arise on the MAWA, such as traveling, standing, and rotating waves. Combining the modes makes it possible to form traps with different cluster geometries, like rotating clusters and ring traps, which offer great potential for mixing particles of different types and diameters.…”

“…Yet, as presented in 70 , discerning the speci c contributions of the ARF and the ASF to the acousto uidic effects induced by GFWs proved challenging through experiments alone, prompting the need for comprehensive acousto uidic simulations to highlight the distinction between these forces Hence, to build upon the previous work, this article presents essential acousto uidic simulation results that elevate one's understanding of the MAWA's operation. Furthermore, novel acousto uidic particle manipulation functions are introduced through experiments targeting particle separation (Fig.…”

“…In the previous paper 70 , the mechanical properties of this waveguide-transducer pair were investigated to highlight the emergence of different GFW vibrational modes populating the membrane waveguide of MAWA. The in-sessile-droplet acousto uidic investigation experimentally identi ed three primary modes and their respective acousto uidic effect: (1) unidirectional traveling waves generate localized evanescent streaming capable of aligning and transporting microparticles, (2) counter-propagating waves interfering can lead into the formation of standing exural waves capable of trapping particles into static clusters, (3) the latter interfering counter-propagating waves can also form rotating exural waves capable of assembling particles into rotating ring traps.…”

Acoustofluidics for simultaneous droplet transport and centrifugation facilitating ultrasensitive biomarker detection

“…Acoustic tweezers based on bulk acoustic waves (BAWs) 18 and surface acoustic waves (SAWs) 19,20 allow for on-chip micro-manipulation that is contactless, 21 non-invasive, 22 and highly biocompatible. 23 Given these unique advantages, acoustic tweezers have become a highly promising manipulation method and could play a crucial role in biomedical detection.…”

Magnetic Lateral Ladder for Unidirectional Transport of Microrobots: Design Principles and Potential Applications of Cells‐on‐Chip

“…Microrobotics is an active research area in biomedical engineering that aims to develop micromanipulations capable of selectively interacting with individual cells. [1][2][3][4][5] These microrobots in size, ranging from 1 μm to tens of μm, can be controlled by various driving forces [6][7][8][9][10][11][12] to carry out specific functions in different experiments, such as selective transportation, [6,[13][14][15][16][17][18] trapping, [19][20][21][22][23] separation, [24][25][26][27][28][29] and mixing. [30][31][32] Due to their small size, microrobot's performances rely on the directional movement of their specific body shape to achieve their functions [33][34][35][36][37][38][39][40][41][42][43][44] rather than having complex components such as their macroscopic counterparts.…”