Microextraction of Furosemide from Human Serum and Its Fluorimetric Determination

Rezazadeh, Akbar; Amjadi, Mohammad; Manzoori, Jamshid L.; Ghaffari, Alireza; Jouyban, Abolghasem

doi:10.15171/ps.2018.11

Cited by 4 publications

(2 citation statements)

References 40 publications

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“…Also, liquidliquid extraction and high-performance liquid chromatography were used for estimation FSD [17,18]. Spectrophotometric methods adopted different reactions for the determination of FSD in pharmaceutical dosage forms [19][20][21][22], finally, reverse-phase high-performance liquid chromatography [23], and flow injection with HPLC [24], as well as HPLC method were used in the estimation of FSD [25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Visible Quantitative Methods for the Estimation of Furosemide in Pure form and Pharmaceutical Formulations

Saleem

Hamdon

Majeed

2021

JPRI

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Aims: Design of technical methods for the determination of Furosemide in its pure and pharmaceutical dosage form using spectral methods. Study Design: planned and executed to estimate Furosemide by using Visible spectrophotometric in pure and pharmaceutical dosage form. Place and Duration of Study: Laboratory of Analytical Research, chemistry department, college of Science, University of Mosul ,Mosul-Iraq, during the period of April 2021 to August 2021. Methodology: Furosemide, the commercially known drug Lazix, which is important in the treatment of heart diseases and high blood pressure. This study was carried out using JASCO V – 630, double-beam computerized UV-Visible spectrophotometer, with 1 cm matched cell, and HANA pH meter was used for reported pH readings. Results: The reaction between Furosemide and bromo-phenol blue, xylenol orange, and chromazorol S. The decreasing in the intensity of the resulted colored complex was measured using bromo-phenol blue, xylenol orange, While the increasing of the color intensity was measured in the method (C). These three methods were based on charge transfer reaction. The limits of Beer's law for method (A) 0.4-32µg. mL-1, method (B) 1-32 and method (C) were 0.8-32 depending on the level of concentration, while the values of the molar absorption coefficient 1.4×104, 2.1×104 and 1.57×104 l.mol-1.cm-1 for the first, second and third method respectively. Sandel's significance also was calculated for these three methods, 0.0157 μg.cm-2 for the first method, 0.0236 μg.cm-2 for the second method, while the third method was 0.0210 μg.cm-2. The method has been successfully applied for the determination of furosemide in its pure form and in some of its pharmaceutical preparations Conclusion: The proposed methods were validated in terms of linearity, range, Accuracy, precision, Specificity, Robustness. The proposed methods were successfully applied to the estimation of Furosemide in pharmaceutical dosage form, method (B) was experimentally considered as a best method depending on the best values of molar absorptivity, stability of the resulted complex, and the linearity of the method (B) .

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Section: Introductionmentioning

confidence: 99%

Visible Quantitative Methods for the Estimation of Furosemide in Pure form and Pharmaceutical Formulations

Saleem

Hamdon

Majeed

2021

JPRI

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“…11 Recently, various miniaturized sample preparation techniques called microextraction methods were used in extraction of various analytes and chemicals from different samples. [12][13][14][15] Liquidliquid extraction and solid phase extraction (SPE) are wellknown extraction procedures. But these methods are not environmentally friendly because of the consumption of large volumes of organic solvents.…”

Section: Introductionmentioning

confidence: 99%

Control of Organophosphorus Pesticides Residues in Honey Samples Using a Miniaturized Tandem Preconcentration Technique Coupled with High Performance Liquid Chromatography

et al. 2020

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Background:In the present work, a miniaturized sample preparation method based on combination of dispersive solid phase extraction and temperature-induced homogenous liquidliquid microextraction has been proposed for the extraction and preconcentration of some organophosphorus pesticides (parathion-methyl, triazophos, parathion, diazinon, and phoxim) from honey samples prior to their analysis by high performance liquid chromatographyultraviolet detection. Methods: In this method, initially the analytes were adsorbed onto a sorbent (C 18 ) and then desorbed by the use of cyclohexyl amine as an eluent. In the next step, the eluent was mixed with water thermostated at 0 °C to obtain a homogenous solution. By increasing the temperature, the solubility of cyclohexyl amine in water was decreased and led to formation of dispersed fine droplets in the whole of solution. These droplets go up through the solution and collected on top of the solution. Finally, an aliquot of the organic phase was sucked in a microsyringe and injected into the separation system for analysis. Results: Under the optimum experimental conditions, limits of detection and quantification were calculated to be in the ranges of 0.90-1.75 and 3.0-5.8 ng g -1 in honey samples, respectively. Enrichment factors and extraction recoveries were in the ranges of 148-183 and 59-73%, respectively. The relative standard deviations varied from 2-4% and 4-5% for intra-(n = 6) and inter-day (n = 4) precisions, respectively. Conclusion: The suggested approach was satisfactorily utilized to the analysis of 21 honey samples. The proposed miniaturized tandem sample pretreatment method enhanced the sensitivity of the instrumental analysis.

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An electrochemical furosemide sensor based on pencil graphite surface modified with polymer film Ni-salen and Ni(OH)2/C nanoparticles

Martins

Bott‐Neto

Raymundo‐Pereira

et al. 2018

Sensors and Actuators B: Chemical

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Microextraction of Furosemide from Human Serum and Its Fluorimetric Determination

Cited by 4 publications

References 40 publications

Visible Quantitative Methods for the Estimation of Furosemide in Pure form and Pharmaceutical Formulations

Visible Quantitative Methods for the Estimation of Furosemide in Pure form and Pharmaceutical Formulations

Control of Organophosphorus Pesticides Residues in Honey Samples Using a Miniaturized Tandem Preconcentration Technique Coupled with High Performance Liquid Chromatography

An electrochemical furosemide sensor based on pencil graphite surface modified with polymer film Ni-salen and Ni(OH)2/C nanoparticles

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