2004
DOI: 10.1038/sj.bjc.6602066
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Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia

Abstract: This study investigated long-term microenvironmental responses (oxygenation, perfusion, metabolic status, proliferation, vascular endothelial growth factor (VEGF) expression and vascularisation) to chronic hypoxia in experimental tumours. Experiments were performed using s.c.-implanted DS-sarcomas in rats. In order to induce more pronounced tumour hypoxia, one group of animals was housed in a hypoxic atmosphere (8% O 2 ) for the whole period of tumour growth (chronic hypoxia). A second group was acutely expose… Show more

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Cited by 26 publications
(14 citation statements)
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References 52 publications
(56 reference statements)
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“…Moreover, acute or chronic hypoxia did not induce angiogenesis in DS sarcomas (Thews et al, 2004). In these tumor models, the various hypoxia exposures decreased or did not alter the microvascular density, and the hypoxia exposures reduced tumor growth.…”
Section: Discussionmentioning
confidence: 81%
“…Moreover, acute or chronic hypoxia did not induce angiogenesis in DS sarcomas (Thews et al, 2004). In these tumor models, the various hypoxia exposures decreased or did not alter the microvascular density, and the hypoxia exposures reduced tumor growth.…”
Section: Discussionmentioning
confidence: 81%
“…Only few data are available, despite the fact that the functional status of a vascular network may have major biological impact on the sensitivity of a tumour towards cytotoxic drugs or irradiation. Tumour angiogenesis shows several structural and functional abnormalities including irregular branching patterns, increased vascular permeability and high amounts of arterio-venous shunt formation which leads to an inadequate perfusion (Thews et al 2004).…”
Section: Discussionmentioning
confidence: 99%
“…Many tumor models have demonstrated a close correlation between local oxygen deficiency and the production of HIF-1α and VEGF [21,22]. HIF-1α activity as well as VEGF secretion is tightly regulated by the oxygen-level, and in the well oxygenated state they are rapidly degraded [24].…”
Section: Discussionmentioning
confidence: 99%