Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma

Li, Luoyuan; Zeng, Zhenhai; Chen, Zhongxing; Gao, Rongyao; Pan, Luting; Deng, Junjie; Ye, Xiuhong; Zhang, Jun; Zhang, Shuangjie; Mei, Chenyang; Yu, Jinjin; Feng, Yifan; Wang, Qinmei; Yu, A-Yong; Yang, Mei; Huang, Jinhai

doi:10.1021/acsnano.0c06000

Cited by 45 publications

(25 citation statements)

References 61 publications

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“…ICG can also improve photothermal therapeutic effects by incorporating rare-earth nanoparticles (Ln: 72% Y 3+ , 20% Yb 3+ ,8% Tm 3+ ) via electrostatic adsorption. Li et al recently created an ICG–rare-earth nanoparticle-loaded hydrogel, with the successful implementation of NIR-triggered release of adriamycin (DOX) [ 92 ].…”

Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

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Photothermal treatment (PTT) is a promising strategy to deal with multidrug-resistant bacteria infection and promote tissue regeneration. Previous studies demonstrated that hyperthermia can effectively inhibit the growth of bacteria, whereas mild heat can promote cell proliferation, further accelerating wound healing and bone regeneration. Especially, hydrogels with photothermal properties could achieve remotely controlled drug release. In this review, we introduce a photothermal agent hybrid in hydrogels for a photothermal effect. We also summarize the potential mechanisms of photothermal hydrogels regarding antibacterial action, angiogenesis, and osteogenesis. Furthermore, recent developments in photothermal hydrogels in wound healing and bone regeneration applications are introduced. Finally, future application of photothermal hydrogels is discussed. Hydrogels with photothermal effects provide a new direction for wound healing and bone regeneration, and this review will give a reference for the tissue engineering.

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Section: Composition Of Hydrogels With Photothermal Effectsmentioning

confidence: 99%

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Zhang

Tan

et al. 2021

Polymers

View full text Add to dashboard Cite

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“…The degradability of the hydrogel composites under physiological conditions is conducive for alleviating long‐term biological toxicity and promoting a photothermal‐chemotherapeutic effect ( Figure 10 ). [ 85 ] Conversely, the biodegradability of nanomedicine remains a particularly important consideration in gene‐based therapies for repeated gene transfection. [ 86 ] Following cell uptake, nanocarriers need to escape intracellular compartments, such as endosomes and lysosomes, to sequentially unpack their gene payloads, such as pDNA and siRNA, via degradation.…”

Section: Fundamental Physicochemical Properties Of Ocular Nanomedicinementioning

confidence: 99%

Ocular Nanomedicine

et al. 2022

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Intrinsic shortcomings associated with conventional therapeutic strategies often compromise treatment efficacy in clinical ophthalmology, prompting the rapid development of versatile alternatives for satisfactory diagnostics and therapeutics. Given advances in material science, nanochemistry, and nanobiotechnology, a broad spectrum of functional nanosystems has been explored to satisfy the extensive requirements of ophthalmologic applications. In the present review, the recent progress in nanosystems, both conventional and emerging nanomaterials in ophthalmology from state-of-the-art studies, are comprehensively examined and the role of their fundamental physicochemical properties in bioavailability, tissue penetration, biodistribution, and elimination after interacting with the ophthalmologic microenvironment emphasized. Furthermore, along with the development of surface engineering of nanomaterials, emerging theranostic methodologies are promoted as potential alternatives for multipurpose ocular applications, such as emerging biomimetic ophthalmology (e.g., smart electrochemical eye), thus provoking a holistic review of "ocular nanomedicine." By affording insight into challenges encountered by ocular nanomedicine and further highlighting the direction of future studies, this review provides an incentive for enriching ocular nanomedicine-based fundamental research and future clinical translation.

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“…They have been incorporated into biodegradable hydrogels based on PNIPAM dual response, which could release the drug in a controlled manner by responding to heat and glutathione in the tumor microenvironment. The nanocomposites were then further decorated with indocyanine green (ICS) and folic acid (FA) to enhance therapeutically and to target specificity and the possibility of achieving photothermal therapy [ 161 ]. A lot of studies showed the potential of therapeutic contact lenses in the management of eye disease [ 162 ].…”

Section: Fluorescent Nanosystems In Ocular Applicationmentioning

confidence: 99%

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

et al. 2022

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The greatest challenge associated with topical drug delivery for the treatment of diseases affecting the posterior segment of the eye is to overcome the poor bioavailability of the carried molecules. Nanomedicine offers the possibility to overcome obstacles related to physiological mechanisms and ocular barriers by exploiting different ocular routes. Functionalization of nanosystems by fluorescent probes could be a useful strategy to understand the pathway taken by nanocarriers into the ocular globe and to improve the desired targeting accuracy. The application of fluorescence to decorate nanocarrier surfaces or the encapsulation of fluorophore molecules makes the nanosystems a light probe useful in the landscape of diagnostics and theranostics. In this review, a state of the art on ocular routes of administration is reported, with a focus on pathways undertaken after topical application. Numerous studies are reported in the first section, confirming that the use of fluorescent within nanoparticles is already spread for tracking and biodistribution studies. The first section presents fluorescent molecules used for tracking nanosystems’ cellular internalization and permeation of ocular tissues; discussions on the classification of nanosystems according to their nature (lipid-based, polymer-based, metallic-based and protein-based) follows. The following sections are dedicated to diagnostic and theranostic uses, respectively, which represent an innovation in the ocular field obtained by combining dual goals in a single administration system. For its great potential, this application of fluorescent nanoparticles would experience a great development in the near future. Finally, a brief overview is dedicated to the use of fluorescent markers in clinical trials and the market in the ocular field.

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Microenvironment-Triggered Degradable Hydrogel for Imaging Diagnosis and Combined Treatment of Intraocular Choroidal Melanoma

Cited by 45 publications

References 61 publications

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

Ocular Nanomedicine

Fluorescent Nanosystems for Drug Tracking and Theranostics: Recent Applications in the Ocular Field

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