Microenvironment-targeted strategy steers advanced bone regeneration

Shen, Hao; Wang, Mingkai; Yin, Zhengyu; Jing, Yingying; Bai, Long; Su, Jiacan

doi:10.1016/j.mtbio.2023.100741

Cited by 10 publications

(6 citation statements)

References 274 publications

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“…During osteogenesis, Mg ions can regulate the expression of genes and proteins that activate multiple signaling pathways related to osteogenesis [ 31 ], increase the expression levels of the angiogenic biomarkers vascular endothelial growth factor, and endothelial nitric oxide synthase [ 32 ], and inhibit osteoclast activity [ 31 ]. Mg ions can play a regulating role in bone microenvironment and promote bone regeneration continuously [ 33 , 34 ]. Based on the present study, it should be noted that different degradation rates of scaffolds could affect the early growth patterns of new bone trabeculae.…”

Section: Discussionmentioning

confidence: 99%

High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects: In vitro and in vivo studies

Liu,

Wang

et al. 2024

Bioactive Materials

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Section: Discussionmentioning

confidence: 99%

High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects: In vitro and in vivo studies

Liu,

Wang

et al. 2024

Bioactive Materials

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“…These conditions usually surpass the body’s inherent capacity for healing, especially in the case of large bone defects, where natural recuperation tends to be protracted and incomplete. The microenvironment of bone defects may impede ECM deposition due to the lack of requisite physical and chemical conditions, such as optimal pH, oxygen levels, and mechanical stress, which are critical for bone tissue regeneration. − The advantage of bone tissue engineering is that it provides alternative approaches to the natural healing process, fostering effective regeneration in regions with bone defects. Compared with traditional grafting techniques, bone tissue engineering circumvents problems associated with donor site morbidity and the limited availability of graft materials. , This review highlights that specific physicochemical properties, electrical charges, or nanotopography of materials can enhance ECM deposition.…”

Section: The Application Of Nanomaterials In Ecm Disorder-related Dis...mentioning

confidence: 99%

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

Zhou,

Zhang,

Zeng

et al. 2024

ACS Nano

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Extracellular matrix (ECM) remodeling is accompanied by the continuous synthesis and degradation of the ECM components. This dynamic process plays an important role in guiding cell adhesion, migration, proliferation, and differentiation, as well as in tissue development, body repair, and maintenance of homeostasis. Nanomaterials, due to their photoelectric and catalytic properties and special structure, have garnered much attention in biomedical fields for use in processes such as tissue engineering and disease treatment. Nanomaterials can reshape the cell microenvironment by changing the synthesis and degradation of ECM-related proteins, thereby indirectly changing the behavior of the surrounding cells. This review focuses on the regulatory role of nanomaterials in the process of cell synthesis of different ECM-related proteins and extracellular protease. We discuss influencing factors and possible related mechanisms of nanomaterials in ECM remodeling, which may provide different insights into the design and development of nanomaterials for the treatment of ECM disorder-related diseases.

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“…However, it is worth noting that most of the in vitro studies focused on osteogenic induction culture of single cells in a planar medium, which may not fully reflect the complex three-dimensional nature of bone remodeling. Bone remodeling involves a multitude of mechanisms [107], such as cell-to-cell interactions [113][114][115][116], cells-to-surrounding environment interactions [117,118], and interactions with hormones and various biological factors [119,120]. The current culture environment does not accurately mimic the bone defect environment.…”

Section: Prospect and Deficiencymentioning

confidence: 99%

Effect of Dimethyloxalylglycine on Stem Cells Osteogenic Differentiation and Bone Tissue Regeneration—A Systematic Review

Dong,

Fei,

Zhang

et al. 2024

IJMS

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Dimethyloxalylglycine (DMOG) has been found to stimulate osteogenesis and angiogenesis of stem cells, promoting neo-angiogenesis in bone tissue regeneration. In this review, we conducted a comprehensive search of the literature to investigate the effects of DMOG on osteogenesis and bone regeneration. We screened the studies based on specific inclusion criteria and extracted relevant information from both in vitro and in vivo experiments. The risk of bias in animal studies was evaluated using the SYRCLE tool. Out of the 174 studies retrieved, 34 studies met the inclusion criteria (34 studies were analyzed in vitro and 20 studies were analyzed in vivo). The findings of the included studies revealed that DMOG stimulated stem cells’ differentiation toward osteogenic, angiogenic, and chondrogenic lineages, leading to vascularized bone and cartilage regeneration. Addtionally, DMOG demonstrated therapeutic effects on bone loss caused by bone-related diseases. However, the culture environment in vitro is notably distinct from that in vivo, and the animal models used in vivo experiments differ significantly from humans. In summary, DMOG has the ability to enhance the osteogenic and angiogenic differentiation potential of stem cells, thereby improving bone regeneration in cases of bone defects. This highlights DMOG as a potential focus for research in the field of bone tissue regeneration engineering.

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Microenvironment-targeted strategy steers advanced bone regeneration

Cited by 10 publications

References 274 publications

High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects: In vitro and in vivo studies

High temperature oxidation treated 3D printed anatomical WE43 alloy scaffolds for repairing periarticular bone defects: In vitro and in vivo studies

Effects of Nanomaterials on Synthesis and Degradation of the Extracellular Matrix

Effect of Dimethyloxalylglycine on Stem Cells Osteogenic Differentiation and Bone Tissue Regeneration—A Systematic Review

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