Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing

Xu, Chong‐Yu; Lin, Tong; Zhao, Xin; Gan, Yanchang; Huang, Jiaxing; Zhang, Jie; Zheng, Haibin; Pu, Chunyi; Lin, Rurong; Yan, Bing; Hu, Guoju; Liu, Qiaolan; Li, Songjian; Hou, Honghao

doi:10.1016/j.compositesb.2023.110726

Cited by 11 publications

(7 citation statements)

References 58 publications

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“…In the FTIR spectrum shown in Figure b, the strong and broad band observed at 3460 cm –1 is ascribed to the −OH stretching vibration . The absorption peak at 1720 cm –1 belongs to the CO of ester groups . The peak observed at 1450 cm –1 comes from C–N stretching .…”

Section: Resultsmentioning

confidence: 96%

“…23 The absorption peak at 1720 cm −1 belongs to the C�O of ester groups. 24 The peak observed at 1450 cm −1 comes from C−N stretching. 25 Moreover, the characteristic peaks exhibited at 1260 and 1186 cm −1 are ascribed to the asymmetric stretching and symmetric stretching of the −CF 3 of Zn(OTf) 2 , respectively.…”

Section: Fabrication and Characterization Of The Phshementioning

confidence: 99%

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Achieving a Reversible and Durable Zn Anode Using the Polyzwitterionic Hydrogel Electrolyte for Efficient Zn-Ion Energy Storage

Xie,

Liang,

Wang

et al. 2023

ACS Appl. Polym. Mater.

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Section: Resultsmentioning

confidence: 96%

Section: Fabrication and Characterization Of The Phshementioning

confidence: 99%

Achieving a Reversible and Durable Zn Anode Using the Polyzwitterionic Hydrogel Electrolyte for Efficient Zn-Ion Energy Storage

Xie,

Liang,

Wang

et al. 2023

ACS Appl. Polym. Mater.

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“…Simultaneously, they are also required to demonstrate excellent biocompatible, tunable mechanical properties and biodegradation as they degrade gradually during tissue repair ( Wu D. et al, 2024 ; Zhou H. et al, 2024 ; Vaidya et al, 2024 ). To date, a variety of natural and synthetic biomaterials have been applied in an attempt to simulate ECM of the natural bone tissue ( Xu et al, 2023 ; Sung et al, 2024 ; Yoon et al, 2024 ). Hydrogels are regarded as the leader in biomedical and tissue regeneration engineering applications, owing to their 3D structure and characters ( Xue et al, 2022b ).…”

Section: Application Of Exogenous Stimulus-responsive In Si...mentioning

confidence: 99%

Smart responsive in situ hydrogel systems applied in bone tissue engineering

Wu,

Gai,

Chen

et al. 2024

Front. Bioeng. Biotechnol.

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The repair of irregular bone tissue suffers severe clinical problems due to the scarcity of an appropriate therapeutic carrier that can match dynamic and complex bone damage. Fortunately, stimuli-responsive in situ hydrogel systems that are triggered by a special microenvironment could be an ideal method of regenerating bone tissue because of the injectability, in situ gelatin, and spatiotemporally tunable drug release. Herein, we introduce the two main stimulus-response approaches, exogenous and endogenous, to forming in situ hydrogels in bone tissue engineering. First, we summarize specific and distinct responses to an extensive range of external stimuli (e.g., ultraviolet, near-infrared, ultrasound, etc.) to form in situ hydrogels created from biocompatible materials modified by various functional groups or hybrid functional nanoparticles. Furthermore, “smart” hydrogels, which respond to endogenous physiological or environmental stimuli (e.g., temperature, pH, enzyme, etc.), can achieve in situ gelation by one injection in vivo without additional intervention. Moreover, the mild chemistry response-mediated in situ hydrogel systems also offer fascinating prospects in bone tissue engineering, such as a Diels–Alder, Michael addition, thiol-Michael addition, and Schiff reactions, etc. The recent developments and challenges of various smart in situ hydrogels and their application to drug administration and bone tissue engineering are discussed in this review. It is anticipated that advanced strategies and innovative ideas of in situ hydrogels will be exploited in the clinical field and increase the quality of life for patients with bone damage.

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“…Besides, independent of iron-chelating properties, DFO shows the capacity for anti-oxidation [ 23 ] and modulating the inflammatory responses. Consequently, these capacities of pro-angiogenesis [ 24 ], improvement of ischemia [ 25 ], and promoted wound healing endow DFO combined grafts or patches gaining increasing interest for repairing various tissue injuries [ 22 , [26] , [27] , [28] , [29] , [73] ]. There is clinical evidence that DFO is beneficial in reducing ischemic injury of isolated kidney during cryopreservation [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

3D hypoxia-mimicking and anti-synechia hydrogel enabling promoted neovascularization for renal injury repair and regeneration

Zhang

Qiu

et al. 2023

Materials Today Bio

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Microenvironment responsive hypoxia-mimetic DFO composite hydrogel for on-demand neovascularization to promote tendon-to-bone healing

Cited by 11 publications

References 58 publications

Achieving a Reversible and Durable Zn Anode Using the Polyzwitterionic Hydrogel Electrolyte for Efficient Zn-Ion Energy Storage

Achieving a Reversible and Durable Zn Anode Using the Polyzwitterionic Hydrogel Electrolyte for Efficient Zn-Ion Energy Storage

Smart responsive in situ hydrogel systems applied in bone tissue engineering

3D hypoxia-mimicking and anti-synechia hydrogel enabling promoted neovascularization for renal injury repair and regeneration

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