Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film

Wang, Donghui; Xing, Shun; Peng, Feng; Zhang, Xianming; Tan, Ji; Hao, Xueqing; Qiao, Yan; Ge, Naijian; Liu, Xuanyong

doi:10.1016/j.bioactmat.2022.06.004

Cited by 7 publications

(2 citation statements)

References 58 publications

(63 reference statements)

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“…For a typical n‐type semiconductor, the E f value obtained from the Mott–Schottky plot is usually ≈0.1 V higher than the CB position. [ 27 ] Therefore, the CB minimum of BTO and BST NPs can be estimated to be −0.18 and −0.21 V (vs NHE), respectively. Furthermore, we used electrochemical impedance spectroscopy (EIS) to investigate the migration capability of charge carriers.…”

Section: Resultsmentioning

confidence: 99%

Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Zhao,

Wang,

Yao

et al. 2023

Small Methods

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The efficacy of sonodynamic therapy (SDT) mainly relies on the sonosensitizers, which generate reactive oxygen species (ROS) upon ultrasound (US) stimulation. However, the limited availability of high‐efficiency sonosensitizers hampers the therapeutic effectiveness of SDT as a standalone modality. In this work, a robust sonodynamic and gas cancer therapeutic platform is constructed based on strontium (Sr) doped barium titanate (BST) piezoelectric nanoparticles functionalized with L‐arginine (BST@LA). The doping of Sr into A site of the ABO3 piezoelectric nanocrystals not only introduces oxygen vacancies into the nanoparticles and enhance the intrinsic piezoelectricity, but also narrows the semiconductor band gap and enhances charge carrier migration, all of which facilitate the sonodynamic production of superoxide anion (•O2−) and hydroxyl radical (•OH). In addition, the generated ROS promotes the decomposition of the surface‐tethered LA, enabling the controlled release of nitric oxide (NO) gas at the tumor site, thereby achieving a combination therapeutic effect. In vivo experiments exhibit remarkable tumor suppression rate (89.5%) in 4T1 tumor mice model, demonstrating the effectiveness of this strategy. The ion doping and oxygen vacancy engineering to improve sonosensitizers, along with the synergistic combination of sonodynamic and gas therapy, provides promising avenues for improving cancer therapy.

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Section: Resultsmentioning

confidence: 99%

Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Zhao,

Wang,

Yao

et al. 2023

Small Methods

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show abstract

“…304 Glutathione (GSH) is the major intracellular reducing substance, 305 involved in physiological processes including protein and DNA synthesis, gene expression and signal transduction through the formation and breaking of disulfide bonds. 306,307 The levels of GSH in tumor cells are 500-fold higher than in healthy cells or tissues, 308 and this difference provides a potentially viable strategy for designing reductive nanoparticle delivery systems. Currently, disulfide bonds are the most widely studied for constructing reduceresponsive NPs.…”

Section: Redox-responsive Npsmentioning

confidence: 99%

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Xing

Zhou

et al. 2023

J. Mater. Chem. B

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Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

Xing,

Wang,

Zhang

et al. 2023

Rare Met.

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Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film

Cited by 7 publications

References 58 publications

Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film

Cited by 7 publications

References 58 publications

Piezoelectric Ba0.85Sr0.15TiO3 Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Piezoelectric Ba0.85Sr0.15TiO3 Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Design and fabrication of intracellular therapeutic cargo delivery systems based on nanomaterials: current status and future perspectives

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Product

Resources

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Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy

Piezoelectric Ba_0.85Sr_0.15TiO₃ Nanosonosensitizer with Nitric Oxide Delivery for Boosting Cancer Therapy