Abstract:Immune checkpoint blockade (ICB) therapies have globally improved the overall survival (OS) of patients with advanced cancers. However, the response rate to these treatments vary widely among patients, therefore exposing non-responders to immune-related adverse events, causing an urgent need of prior-treatment predictors of response to ICB. We investigated the tumor microenvironment (TME) of clear cell renal cell carcinoma (ccRCC) samples from primary and metastatic sites to identify predictive molecular and c… Show more
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