Microenvironment Eradication of Hepatitis C: A Novel Treatment Paradigm

Cuadrado, Antonio; Llerena, Susana; Cobo, Carmen; Pallás, José Ramón; Mateo, Miguel Á.; Cabezas, Joaquín; Fortea, José Ignacio; Álvarez, Silvia; Pellón, Raúl; Crespo, Juan J.; Echevarría, S.; Ayesa, Rosa; Setién, Esther; López‐Hoyos, Marcos; Crespo‐Facorro, Benedicto; Agüero, Jesús; Chueca, Natalia; García, Francisco Blanco; Calleja, José Luís; Crespo, Javier

doi:10.1038/s41395-018-0157-x

Cited by 73 publications

(69 citation statements)

References 25 publications

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“…Moreover, they should not be considered the target of HCV elimination strategies themselves, but rather a brick in the achievement of HCV eradication in the entire population. Evidence supporting feasibility and effectiveness of micro‐elimination strategies is mounting, both in developed countries and LMICs and in different target populations …”

Section: Eradication and Eliminationmentioning

confidence: 99%

“…b IFN-based regimens.achievement of HCV eradication in the entire population. Evidence supporting feasibility and effectiveness of micro-elimination strategies is mounting, both in developed countries and LMICs and in different target populations [44][45][46][47][48]. 6 | S PECIAL P OPUL ATIONSTargeting HCV eradication in specific high-risk populations appears to be a highly effective strategy to reduce disease burden.…”

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confidence: 99%

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Hepatitis C: Is eradication possible?

Lombardi

Mondelli

2019

Liver International

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Hepatitis C has a relevant global impact in terms of morbidity, mortality and economic costs, with more than 70 million people infected worldwide. In the resolution, “Transforming our world: the 2030 Agenda for Sustainable Development” was included as a focus area in the health‐related goal with world leaders pledging to “combat” it by 2030. In response, WHO drafted the Global Viral Hepatitis Strategy carrying the ambitious targets to reduce the number of deaths by two‐thirds and to increase treatment rates up to 80%. Despite the availability of highly effective therapeutic regimens based on direct‐acting antivirals many barriers to HCV eradication still remain. They are related to awareness of the infection, linkage to care, availability of the therapeutic drug regimens and reinfection. Overall, if an effective prophylactic vaccine will not be available, HCV eradication appears difficult to achieve in the future.

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Section: Eradication and Eliminationmentioning

confidence: 99%

mentioning

confidence: 99%

Hepatitis C: Is eradication possible?

Lombardi

Mondelli

2019

Liver International

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“…A Spanish study demonstrated that HCV elimination is possible in a prison setting. Using a test‐and‐treat strategy, the prison tested 99.5% of its inmates, treated all who were infected and would be incarcerated more than 30 days, established a teleconsultation programme for those who were released, and achieved SVR in 97% of the treated prisoners (Table , Case 5) .…”

Section: Wherementioning

confidence: 99%

We know DAAs work, so now what? Simplifying models of care to enhance the hepatitis C cascade

et al. 2019

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“…102 Notably, this study also created a sustainable model for continuance: even after its completion, all new prisoners are offered treatment. 103 Rapid HCV testing and DAA treatment can also feasibly be delivered in transient jail populations, where inmates are often detained for fairly short or unpredictable periods of time, as observed by two studies conducted in the United States. 95,104 In many countries, however, it is common for remand prisoners to be incarcerated for 1 week or less.…”

Section: Prisonersmentioning

confidence: 99%

The Micro-Elimination Approach to Eliminating Hepatitis C: Strategic and Operational Considerations

et al. 2018

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The introduction of efficacious new hepatitis C virus (HCV) treatments galvanized the World Health Organization to define ambitious targets for eliminating HCV as a public health threat by 2030. Formidable obstacles to reaching this goal can best be overcome through a micro-elimination approach, which entails pursuing elimination goals in discrete populations through multi-stakeholder initiatives that tailor interventions to the needs of these populations. Micro-elimination is less daunting, less complex, and less costly than full-scale, country-level initiatives to eliminate HCV, and it can build momentum by producing small victories that inspire more ambitious efforts. The micro-elimination approach encourages stakeholders who are most knowledgeable about specific populations to engage with each other and also promotes the uptake of new models of care. Examples of micro-elimination target populations include medical patients, people who inject drugs, migrants, and prisoners, although candidate populations can be expected to vary greatly in different countries and subnational areas.

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Microenvironment Eradication of Hepatitis C: A Novel Treatment Paradigm

Abstract: A sustained "test-and-treat" strategy against HCV in prisons is feasible and beneficial. Spreading this strategy should entail a public health impact.

Cited by 73 publications

References 25 publications

Hepatitis C: Is eradication possible?

Hepatitis C: Is eradication possible?

We know DAAs work, so now what? Simplifying models of care to enhance the hepatitis C cascade

The Micro-Elimination Approach to Eliminating Hepatitis C: Strategic and Operational Considerations

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