Microenvironment and HIV-related lymphomagenesis

Pantanowitz, Liron; Carbone, Antonino; Dolcetti, Riccardo

doi:10.1016/j.semcancer.2015.06.002

Cited by 39 publications

(25 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pantanowitz et al [13] describe the microenvironmental features leading to lymphomagenesis in HIV-associated lymphomas. While the pathogenesis of these lymphomas is only partly understood, a large body of evidence indicates that immune deregulation and cytokine production play an essential role in HIV-lymphomagenesis [13]. Dolcetti [14] focuses on EBV-driven lymphomagenesis.…”

Section: Introductionmentioning

confidence: 99%

Lymphomas and microenvironment: Impact on lymphomagenesis

Carbone

Younes

2015

Seminars in Cancer Biology

Self Cite

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Lymphomas and microenvironment: Impact on lymphomagenesis

Carbone

Younes

2015

Seminars in Cancer Biology

Self Cite

View full text Add to dashboard Cite

“…In fact, virtually all these cases show HRS cells harboring EBV genome and intensely expressing the LMP‐1 viral oncoprotein, whereas only 20–50% of HIV‐unrelated cases carry EBV infection. Although the pathogenic mechanisms underlying the close association of HIV‐related cHL with EBV are still unknown, it is likely that the development of this tumor and the distinctive features of its microenvironment are the result of the complex interplay between HIV and EBV, as in the case of most HIV‐associated non‐Hodgkin lymphomas . Viral cooperation is a mechanism by which different viruses co‐infecting human tissues have synergistic or regulatory effects on carcinogenesis .…”

Section: The Microenvironmental Niche Of Hiv‐related Chlmentioning

confidence: 99%

“…Although the pathogenic mechanisms underlying the close association of HIV-related cHL with EBV are still unknown, it is likely that the development of this tumor and the distinctive features of its microenvironment are the result of the complex interplay between HIV and EBV, as in the case of most HIV-associated non-Hodgkin lymphomas. 112 Viral cooperation is a mechanism by which different viruses co-infecting human tissues have synergistic or regulatory effects on carcinogenesis. 113 In HIV-related cHL, cooperation between EBV and HIV probably occurs mainly through indirect interactions mediated by cellular dysregulation/immunodeficiency or chronic antigenic stimulation/inflammation.…”

Section: The Microenvironmental Niche Of Hiv-related Chlmentioning

confidence: 99%

The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis

et al. 2016

Self Cite

View full text Add to dashboard Cite

The pathogenesis of classical Hodgkin lymphoma (cHL) is still enigmatic, largely because its tumor cells, the so-called Hodgkin and Reed-Stenberg (HRS) cells, invariably reside in a prominent reactive microenvironment, are rare and therefore difficult to analyze. On the other hand, the broadly investigated cHL-derived cell lines are not unequivocally considered as suitable and representative models for this puzzling disease. Based on current knowledge, it appears that the cross talk between the tumor cells and the reactive infiltrate of the microenvironment is complex and that multiple mechanisms occur, making cHL a very heterogeneous disease. In 20-40% of cHL cases, HRS cells carry a monoclonal infection by Epstein Barr virus (EBV), which is considered a tumor-initiating factor. In these cases, EBV shows a latency type II infection pattern with the expression of latent membrane protein-1 (LMP-1), a viral oncoprotein that mimics CD40 activation. This scenario is particularly intriguing for the pathogenesis of cHL arising in HIV-infected patients, which, for still obscure reasons, is invariably EBV-associated with LMP-1 expression in HRS cells. Recent evidences are consistent with the occurrence of different pathogenic pathways variably triggered by virus infections (EBV and HIV), genetic alterations, and interactions with critical microenvironmental components. This review focuses on the different microenvironmental niches that characterize cHL of the general population as well as cases of HIV-infected patients. A more comprehensive understanding of the complex interplay existing between HRS and tumor microenvironment is pivotal for the development of more effective treatments, particularly for relapsed or refractory diseases.

show abstract

“…The incidence of cHL in the HIV setting have increased 5-25-fold, suggesting that despite suppressive cART, the ongoing immune suppression (driven by ongoing HIV replication among other factors) and the aged population have contributed to this rise [7][8][9][10][11][12][13]. On the other hand, individuals with severe immune suppression have a lower cHL incidence, suggesting that the improvement of CD4 counts associated to cART and the rise of immune competence may explain the observed increase of cHL incidence [14][15][16][17][18][19]. Moreover, the incidence of cHL among HIV-1-infected individuals has been estimated to be 10-20-fold higher than in the general population [7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Hernández-Walias

Vázquez

Pacheco

et al. 2020

JCM

View full text Add to dashboard Cite

The incidence of classical Hodgkin lymphoma (cHL) in the HIV-1 setting has increased 5–25-fold compared to that observed in the general population. This study aimed to determine whether selected micro RNAs (miRs) and other soluble biomarkers and cellular subsets are dysregulated in cHL and could be used as biomarkers. This was a retrospective and longitudinal matched case-control study of 111 Caucasian, HIV-1-infected adult individuals, including 37 individuals with cHL and 74 with no type of cancer. Immunovirological data, plasma exosome-derived miR-16, miR-20a, miR-21, miR-221, miR-223, miR-106a, miR-185, miR-23, miR-30d, miR-222, miR-146a and miR-324, plasma IL-6, sCD14, sCD27, sCD30, sIL-2R, TNFR1, and cell phenotyping of T and B lymphocytes and natural killer (NK) cells were analyzed. Before cHL diagnosis, miR-20a, miR-21, and sCD30 were higher in cHL (p = 0.008, p = 0.009 and p = 0.042, respectively), while miR-16 was down-regulated (p = 0.040). miR-20a and miR-21 were independently associated with cHL (p = 0.049 and p = 0.035, respectively). The combination of miR-20a and miR-21 showed a good AUC value of 0.832 with a moderate likelihood ratio positive (LR+) value of 5.6 and a slight likelihood ratio negative (LR−) value of 0.23. At cHL diagnosis, miR-20a, miR-21 and miR-324 were overexpressed in cHL (p = 0.005, p = 0.024, and p = 0.001, respectively), while miR-223, miR-16, miR-185 and miR-106a were down regulated (p = 0.042, p = 0.007, p = 0.006, and p = 0.002, respectively). In addition, sCD14, sCD27, sCD30 and IL2R levels were higher in these individuals (p = 0.038, p = 0.010, p = 0.030, p = 0.006, respectively). miR-20a was independently associated with cHL (p = 0.011). The diagnostic value of miR-20a showed good AUC value of 0.754 (p = 0.074) with a slight LR+ value of 2 and a slight LR− of 0.25. After chemotherapy, miR-20a was higher in those individuals who had an adverse outcome (p < 0.001), while sCD14 and sCD30 were higher (p < 0.001). A specific signature of miRs and cytokines associated with a subsequent cHL diagnosis was found in this study, especially miR-20a and miR-21. Also, another biomarker signature was found at cHL diagnosis, with a relevant discriminant disease value for miR-20a. Of note, miR-20a expression was higher in those individuals who had an adverse clinical outcome after chemotherapy.

show abstract

Microenvironment and HIV-related lymphomagenesis

Cited by 39 publications

References 40 publications

Lymphomas and microenvironment: Impact on lymphomagenesis

Lymphomas and microenvironment: Impact on lymphomagenesis

The impact of EBV and HIV infection on the microenvironmental niche underlying Hodgkin lymphoma pathogenesis

Risk, Diagnostic and Predictor Factors for Classical Hodgkin Lymphoma in HIV-1-Infected Individuals: Role of Plasma Exosome-Derived miR-20a and miR-21

Contact Info

Product

Resources

About