Microencapsulation of riboflavin with galactomannan biopolymer and F127: Physico-chemical characterization, antifungal activity and controlled release

Farias, Silvana Silveira de; Siqueira, Sônia Maria Costa; Cunha, Arcelina Pacheco; Souza, Carlos Alberto G.; Fontenelle, Raquel Oliveira dos Santos; Araújo, Tamara Gonçalves de; Amorim, Antônia Fádia Valentim de; Menezes, Jane Eire Silva Alencar de; Morais, Selene Maia de; Ricardo, Nágila Maria Pontes Silva

doi:10.1016/j.indcrop.2018.03.039

Cited by 29 publications

(11 citation statements)

References 49 publications

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“…The photomicrographs demonstrated a homogeneous peptide entrapment within the microcapsule structure. Also, it can clearly observe the difference between the blank capsules that contain only sodium alginate, revealing uniform and completely homogeneous branches, in according with some authors (de Farias et al, 2018; Hartmann et al, 2010). However, the surface-formed microcapsules do not show a circular shape as found on their initial shape (data not shown), effect caused by water decrease after drying.…”

Section: Resultssupporting

confidence: 76%

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive

Roque‐Borda

Silva

Crusca

et al. 2021

Preprint

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Microencapsulation is a potential biotechnological tool, which can overcome AMPs instabilities and reduce toxic side effects. Thus, this study evaluates the antibacterial activities of the Ctx(Ile21)-Ha antimicrobial peptide against MDR and non-resistant bacteria, develop and characterize peptide-loaded microparticles coated with HPMCAS and HPMCP. Ctx(Ile21)-Ha microencapsulation was performed by ionic gelation with high-efficiency, maintaining the physical-chemical stability. Ctx(Ile21)-Ha coated-microparticles were characterized, and their hemolytic activity assay demonstrated that hemolysis was decreased up to 95% compared to single molecule. In addition, in vitro release control profile simulating different portions of gastrointestinal tract was performed and showed the microcapsules ability to protect the peptide and release it in the intestine, aimed pathogens location, mainly by Salmonella sp. Therefore, use of microencapsulated Ctx(Ile21)-Ha can be allowed as an antimicrobial controller in monogastric animal production, being a valuable option for molecules with low therapeutic indexes or high hemolytic rates.

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Section: Resultssupporting

confidence: 76%

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive

Roque‐Borda

Silva

Crusca

et al. 2021

Preprint

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“…It should be noted that microencapsulation of riboflavin, a water-soluble vitamin acting as cofactor in various processes of oxidation-reduction in a cellular system, with galactomannan biopolymer and Pluronic ® F127 resulted in its slower release in both acidic and basic media compared to free vitamin [ 163 ].…”

Section: Antioxidantsmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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“…Among the many available controlled release systems, the successful use of polymer microparticles has been reported in the literature in distinct biomedical applications . Microparticles are characterized by characteristic sizes ranging from 1 to 1000 µm and can be applied in the form of microspheres or microcapsules: while microspheres are constituted by compact polymer matrixes (which may contain a dispersed drug), microcapsules are constituted by a rigid polymer wall that surrounds a core of distinct composition (where the drug is usually present)…”

Section: Introductionmentioning

confidence: 99%

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Paiva

Alves

Melo

et al. 2019

Macro Reaction Engineering

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Schistosomiasis is a parasitic disease that affects millions of people, especially low‐income people, and is considered a major public health problem in underdeveloped countries. The drug used most often for the treatment of the disease is praziquantel (PZQ), which has a strong and characteristic bitter taste that makes treatment of children inconvenient. For this reason, the present work investigates the development of smart pH‐sensitive polymer microparticles produced through suspension polymerizations to be used as vehicles for the controlled release of praziquantel in the body. The microparticles are produced through copolymerization of methyl methacrylate and the cationic comonomers diethylaminoethyl methacrylate or dimethylaminoethyl methacrylate. The obtained results indicate that microparticles with sizes in the range of 10–1100 µm can be formed successfully, allowing high PZQ encapsulation efficiencies (>80%). Zeta potential analyses and drug release assays confirm the pH‐sensitive responses of the cationic copolymers, leading to effective release of PZQ (around 80% in pH 1.2) in acidic media that simulate the organic fluids present in the stomach.

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Microencapsulation of riboflavin with galactomannan biopolymer and F127: Physico-chemical characterization, antifungal activity and controlled release

Cited by 29 publications

References 49 publications

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

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Microencapsulation of riboflavin with galactomannan biopolymer and F127: Physico-chemical characterization, antifungal activity and controlled release

Cited by 29 publications

References 49 publications

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile21)-Ha antimicrobial peptide application as a feed additive

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile21)-Ha antimicrobial peptide application as a feed additive

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Development of Smart Polymer Microparticles through Suspension Polymerization for Treatment of Schistosomiasis

Contact Info

Product

Resources

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Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive

Alginate-based microparticles coated with HPMCP/AS cellulose-derivatives enable the Ctx(Ile²¹)-Ha antimicrobial peptide application as a feed additive