Microencapsulated Mitomycin-C Therapy in Renal-Cell Carcinoma

Emerging Frontiers in Drug Delivery

“…From these early findings the field of drug delivery and controlled release evolved rapidly (Figure ). Osmotic pumps were employed as oral CRS, − drug-loaded hydrogels were applied as ophthalmic DDS, − microsphere encapsulation was used for sustained release, − researchers developed mathematical models to quantify drug release from CRS, − and the ALZA corporation was founded to commercialize CRS . A comprehensive history of the fields of drug delivery and controlled release are beyond the scope of this Perspective, and we direct the reader to additional reviews. ,− …”

Advances in Biomaterials for Drug Delivery

“…[23d] This work further led to the development of an early drug delivery system approved by the U.S. Food and Drug Administration (FDA) in 1990, Norplant (now Jadelle), a contraceptive composed of silicone rubber tubes implanted in the forearm that releases levonorgestrel for up to 5 years with pregnancy rates of less than 1% per year. [25] Research within the field of biomaterials, drug delivery, and controlled release accelerated during this period, giving rise to the development of osmotic pumps for oral drug delivery in dogs, [26] drug-loaded hydrogels for ophthalmic drug delivery, [27] polymeric and albumin microsphere-based encapsulation for sustained release of drugs in rats, rabbits, and humans, [28] as well as new mathematical models to quantify drug release from biomaterials. [29] Hydrogels, 3D networks of polymer chains crosslinked to form matrices with high water content, are now widely used in drug delivery and tissue engineering due to their tunable physical, chemical, and biological properties.…”

Drug Targeting in Cancer Chemotherapy: A Clinical Perspective

“…139 In their other study, 56 patients with invasive or nonresectable neoplasms received 10 to 40 mg of mitomycin C in single or divided doses via ethylcellulose microcapsules.140 The treatment resulted in >30% reduction in the diameter of at least 65% of the tumors, along with pain relief in 80% of the cases and hemostasis in all subjects. The antitumor effects of this therapy were witnessed radiologically as well as histologically.…”