Microemulsions versus micelles

Prince, Leon M.

doi:10.1016/0021-9797(75)90315-x

Cited by 72 publications

(16 citation statements)

References 16 publications

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“…15,16 As a result, the addition of short-chain alcohols as cosurfactants is able to reduce interfacial free energy and tension by their incorporation into the interfacial layer. This kind of cosurfactant also modifies the HLB value of the surfactant to an optimal value suitable for microemulsion formulation.…”

Section: Resultsmentioning

confidence: 99%

Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs

Ho¹,

Hsiao²,

Sheu³

1996

Journal of Pharmaceutical Sciences

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Phase diagrams containing the microemulsion region were constructed for pseudo-ternary systems composed for polyglycerol fatty acid ester/cosurfactant/Captex 300/water. It was found necessary to add ethanol, 1-propanol, 1-butanol as cosurfactant to produce microemulsions. The results also demonstrated microemulsions were only able to form when employing polyglycerol fatty acid esters with hydrophile-lipophile balances (HLBs) between 8 and 13, such as MO500, MO750, SO750, and ML310. Most microemulsions were determined to be Winsor type IV by dilution and dye solubility tests. Microemulsions stored at ambient temperature maintained constant viscosity, indicating that the system was thermodynamically stable for long periods. Further, several microemulsion formulations were demonstrated to be promising for oral delivery of insulin based on the results of stability tests and acid-protection efficiency.

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Section: Resultsmentioning

confidence: 99%

Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs

Ho¹,

Hsiao²,

Sheu³

1996

Journal of Pharmaceutical Sciences

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“…Subsequent analysis indicated that the particle size of the microemulsion phase was < 200 nm. There has been a long controversy over what constitutes a microemulsion and whether it is an emulsion or a micelle (52,53). It is now generally recognized as the thermodynamically stable micellar or swollen micellar system of lipid, surfactant and water (54).…”

Section: Discussionmentioning

confidence: 99%

A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development

Dalrymple²,

2011

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PurposeTo compare physiochemical properties of mono-, di- and triglycerides of medium chain fatty acids for development of oral pharmaceutical dosage forms of poorly water-soluble drugs using phase diagrams, drug solubility, and drug dispersion experiments.MethodsPhase diagrams were prepared using a monoglyceride (glycerol monocaprylocaprate: Capmul MCM® EP), a diglyceride (glycerol dicaprylate) and two triglycerides (glycerol tricaprylate: Captex 8000®; caprylic/capric triglycerides: Captex 355 EP/NF®) in combination with a common surfactant (PEG-35 castor oil: Cremophor EL®) and water. Psuedoternary phase diagrams using mixtures of monoglyceride with either diglyceride or triglyceride were constructed to determine any potential advantage of using lipid mixtures.ResultThe monoglyceride gave microemulsion (clear or translucent liquid) and emulsion phases, whereas di- and triglycerides exhibited an additional gel phase. Among individual mono-, di- and triglycerides, the oil-in-water microemulsion region was the largest for the diglyceride. Gel phase region within diglyceride and triglyceride phase diagrams could be practically eliminated and microemulsion regions expanded by mixing monoglyceride with di- or tri-glycerides (1:1). Addition of a model drug, danazol, had no effect on particle sizes of microemulsions formed. Dispersion of drug in aqueous media from mixtures of mono- and diglyceride or mono- and triglyceride was superior to individual lipids.ConclusionSystematic study on comparison of mono-, di- and triglyceride of medium chain fatty acids will help formulators select components for optimal lipid-based formulation.

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“…Researches on micelle have been mainly focused on the thermodynamic and structural properties at various conditions of micellization such as concentration and temperature [1][2][3][4][5][6][7]. Recently, the scope of the study has been expanded to synthesize various types of amphiphilic molecules in order to harness the properties of micelle for various applications utilizing the compartmentalization capability such as drug delivery [8][9][10][11][12], nano-reactor [13][14][15][16] and so on.…”

Section: Introductionmentioning

confidence: 99%

Molecular dynamics simulation study of sodium dodecyl sulfate micelle: Water penetration and sodium dodecyl sulfate dissociation

Chun

Choi

Jang

2015

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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h i g h l i g h t s• SDS micelle was simulated for 20 ns using all-atom MD simulation.• SDS conformations are mostly bent in micelle.• Free volume in SDS micelle is ∼0.35% of the micelle volume.• Free energy change for water penetration through SDS micelle is ∼10 kcal/mol.• Dissociation of a single SDS molecule from the micelle requires ∼13 kcal/mol. g r a p h i c a l a b s t r a c t a b s t r a c tWe investigate a micelle consisting of 60 sodium dodecyl sulfate (SDS) molecules in water phase using molecular dynamics simulation method. The dimension of the micelle is evaluated as ∼16Å and ∼21Å for the radius of gyration and geometric radius, respectively, which are well agreed with the previous studies. By calculating the formation energy, it is found that the stability of micelle is driven by the interaction of the micelle with water phase. Via Connolly surface analysis, it was found that ∼58% of the micelle surface is occupied by the hydrophobic alkyl tails. The conformation analysis shows that the individual SDS molecules are bent within the micelle and are not aligned radially from the center-of-mass of the micelle. However, it turns out that the micelle is well packed with a small free volume (0.35% of the micelle volume) which does not allow the diffusion-in of water molecules. The PMF required to drag a water molecule from water phase to the center-of-mass of micelle is calculated as ∼10 kcal/mol while the PMF for a SDS molecule to be dissociated from the micelle is ∼13 kcal/mol, both of which demonstrate that the micellization is driven by minimizing unfavorable interaction of hydrophobic alkyl tail of SDS molecule with water phase.

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Microemulsions versus micelles

Cited by 72 publications

References 16 publications

Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs

Preparation of Microemulsions Using Polyglycerol Fatty Acid Esters as Surfactant for the Delivery of Protein Drugs

A Comparative Evaluation of Mono-, Di- and Triglyceride of Medium Chain Fatty Acids by Lipid/Surfactant/Water Phase Diagram, Solubility Determination and Dispersion Testing for Application in Pharmaceutical Dosage Form Development

Molecular dynamics simulation study of sodium dodecyl sulfate micelle: Water penetration and sodium dodecyl sulfate dissociation

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