Microemulsions as Potent Drug Delivery Systems

Mj, Nirmala; Nagarajan, R.

doi:10.4172/2157-7439.1000e139

Cited by 1 publication

(1 citation statement)

References 3 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies indicated that the encapsulation and emulsification of vegetable oils due to the anti-cancer effects of these compounds can lead to their widespread use in inhibiting cancer cells. Studies have been conducted on the use of vegetable oils, like dill (Anethum graveolens L) [12] in the treatment of some cancers, including breast and liver types [11]. The present study examined the effects of different concentrations of dandelion essential oil nanoemulsion using the CAM method.…”

Section: Introductionmentioning

confidence: 99%

Investigating the Anti-angiogenic Effects of Nanoemulsion Synthesized From Plant Anethum Graveolens L Essential Oil

2021

View full text Add to dashboard Cite

Background and Aim: Angiogenesis is the process of forming new blood vessels from the old ones; it plays an important role in physiological conditions, such as growth, wound healing, and reproduction. This process also plays a vital role in pathological phenomena and the occurrence of various diseases, especially tumor growth and metastasis. The present study evaluated the anti-angiogenic effects of nanoemulsion synthesized from Anethum graveolens essential oil using the CAM method. Methods & Materials: To investigate the anti-angiogenic effects on the second day of incubation, a window was opened on the eggs. Subsequently, on the eighth day, a gelatin sponge with nanoemulsion with different doses (12.5, 25, and 50 μg/mL) was inserted on the chorioallantoic membrane. On the 12th day of incubation, a research stereomicroscope was used to evaluate the rate of angiogenesis and imaging of the treated area. Vascular factors were examined by Image J software. Ethical Considerations: This study was approved by the Research Ethics Committee of Mashhad Branch, Islamic Azad University (Code: IR.IAU.MSHD.REC.1398.027). Results: The obtained results concerning the effect of nanoemulsion on the rate of angiogenesis in the CAM test indicated a decrease in the length and number of vessels of the chorioallantoic membrane in the treated samples, compared to the controls. Moreover, there was a reduction in the height and weight of treated fetuses, compared to the untreated fetuses (P<0.05). Conclusion: The anti-angiogenic activity of nanoemulsion synthesized from Anethum graveolens essential oil indicated the possible use of this substance for diseases, like cancer, in which the formation of blood vessels is inhibited. Therefore, Anethum graveolens nanoemulsion can be suggested as an agent for further cancer studies.

show abstract

Section: Introductionmentioning

confidence: 99%