Microemulsion preparation of Waltheria indica extracts and preliminary antifungal mechanism exploration

Yin, Fengman; Liu, Qifeng; Zhang, Beijing; Zhang, Xi; He, Jianguo; Xie, Jia; Hu, Zheng; Sun, Ranfeng

doi:10.1016/j.indcrop.2021.114000

Cited by 10 publications

(10 citation statements)

References 66 publications

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“…The decrease in ergosterol level shows that the R. rubescens extract has an inhibitory effect on the synthesis of the intracellular substances of fungi (Oktay Başeğmez et al, 2021). The antifungal effect of R. rubescens extract on Ascochyta molleriana wint is achieved by damaging the cell membrane and inhibiting the synthesis of protein, which is consistent with the antibacterial mechanism clarified by other natural antibacterial agents and has a guiding significance for the antifungal research of oridonin in R. rubescens (Ju et al, 2020;Meng et al, 2020;Yin et al, 2021). On this basis, we can conduct antifungal research on oridonin, a single component from Rabdosia rubescens, especially its influence on the fungal gene level to explore the antifungal mechanism and target of oridonin to make oridonin more broad-spectrum and effective.…”

Section: Antifungal Mechanism Of Rabdosia Rubescens Extractsupporting

confidence: 64%

Antimicrobial activity of oridonin

Zhou

2023

Food Sci. Technol

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Oridonin is an enantiomer-kaurene tetracyclic diterpenoid compound, which is the main active component of Rabdosia rubescens, a herb used in traditional Chinese medicine. It has been reported to exert anti-tumor, anti-inflammatory, proapoptotic, anti-angiogenic, neuroprotective, and other pharmacological effects. Owing to the overuse of antibiotics, currently, the medical and food industries are facing drug resistance challenges, which have severely impacted food and medical safety. Thus, new antibacterial agents must be identified. As an important active component of Rabdosia rubescens, oridonin has been extensively and deeply studied in antimicrobial aspects. This paper reviews the antimicrobial activity of oridonin and its underlying mechanism. In addition, its safety and application as an antibacterial agent were briefly introduced. Finally, the current problems and challenges of the application of oridonin and the prospects were also elucidated.

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Section: Antifungal Mechanism Of Rabdosia Rubescens Extractsupporting

confidence: 64%

Antimicrobial activity of oridonin

Zhou

2023

Food Sci. Technol

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“…Some of these components got wrapped inside the ME structure, resulting in smaller particle sizes, while some got distributed in the outer phase or surfactant layer of the ME structure, resulting in larger particle sizes of CIA-ME . The emulsifier used prevents the coalescence of the oil phase, making the ζ-potential of the prepared microemulsion reach about −30 mV and maintaining certain system stability . Meanwhile, ME and CIA-ME showed no apparent change in the pH and centrifugal test (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The samples were separately stored in airtight glass containers in triplicate and were periodically inspected on days 0, 7, 15, 30, and 90 . The visual phase separation of samples was assessed by centrifugation at 5000 rpm for 30 min. , The following measurements of physical stability are taken during this period: phase separation, appearance changes, particle size, and PDI.…”

Section: Methodsmentioning

confidence: 99%

Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Feng

et al. 2023

ACS Sustainable Chem. Eng.

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The essential oil extracted from the flowers of Chrysanthemum indicum var. aromaticum (CIA) has excellent biological properties; however, the stems and leaves of CIA often get wasted. Maximizing the use of these wastes will help solve the sustainability issues of CIA resources. The present study analyzed the chemical compositions of CIA flower essential oil (CO) and stem and leaf extract (CE) by gas chromatography–mass spectrometry (GC–MS) and ultra-performance liquid chromatography–mass spectrometry (UPLC-MS). Then, the phytochemical properties, stability, antioxidant capacity, and cell (human L929) toxicity of CO and CE were further evaluated. Finally, oil-in-water microemulsion (ME) and hyaluronic acid hydrogel systems composed of CO and CE were developed to deliver bioactive ingredients effectively. The analysis identified 64 and 31 compounds in CO and CE, respectively, and indicated them as readily available sources of natural antioxidants, such as flavonoids and phenols. In addition, the formulation of the ME system (CIA-ME) improved CO stability and increased CE loading; these optimal formulations (ME, CIA-ME, CIA-ME gel) exhibited good stability, rheological properties, and sustained release properties without causing cell toxicity and skin irritation. The CIA-ME significantly inhibited intracellular tyrosinase activity and decreased intracellular melanin production in a dose-dependent manner. It also demonstrated skin photoprotection and inhibited tyrosinase, collagenase, and elastase activities. Overall, CIA as a plant raw material can serve as a promising topical cosmetic or medicine prototype. Applying CO and CE in combination provides a basis for the sustainable utilization of CIA resources.

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“…[2][3][4][5] Reportedly, China has more than 1.3 million hectares of chili industry with an annual output value of nearly 27 billion US dollars. [6] Therefore, it is urgent to explore and develop new and low toxicity botanical fungicides to control P. capsici. [7 -9] Plant-parasitic nematode is one of the most harmful plant pathogens, which has become the second destructive pathogen in agricultural production.…”

Section: Introductionmentioning

confidence: 99%

“…It can also infect more than 50 species of agriculturally important vegetables and fruits, for example cucurbitaceous, solanaceous, and fabaceous crops, seriously threatening their yield and quality [2–5] . Reportedly, China has more than 1.3 million hectares of chili industry with an annual output value of nearly 27 billion US dollars [6] . Therefore, it is urgent to explore and develop new and low toxicity botanical fungicides to control P. capsici [7–9] …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Hinokitiol Sulfonate Derivatives and Their Anti‐Oomycete and Nematicidal Activities

Che

Liu

Chen

et al. 2022

Chemistry & Biodiversity

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In order to explore novel natural product-based anti-oomycete and nematicidal agents, sixteen unreported 2sulfonyloxyhinokitiol derivatives were prepared using the principle of active splicing, and structurally confirmed by proton nuclear magnetic resonance ( 1 H-NMR), carbon-13 nuclear magnetic resonance ( 13 C-NMR), highresolution mass spectrometry (HRMS), and melting point. Moreover, we evaluated the title compounds as antioomycete and nematicidal agents against two serious agricultural pests of Phytophthora capsici and Meloidogyne incongnita. Among the sixteen hinokitiol esters tested: (1) Compounds 3a and 3m exhibited the most potent anti-oomycete activity compared to zoxamide against P. capsici, and the median effective concentration (EC 50 ) values of 3a, 3m, and zoxamide were 18.64, 21.11, and 23.15 mg/L, respectively; Further studies showed that the existence of seven membered ring and carbonyl group was the necessary condition for the high anti-oomycete activity of hinokitiol. (2) Compounds 3n and 3p exhibited more promising nematicidal activity than hinokitiol, and the median lethal concentration (LC 50 ) values of 3n, 3p and 1 against M. incongnita were 0.2111, 0.2079, and 0.3933 mg/L, respectively. This result will pave the way for further modification of hinokitiol to develop potential new fungicides and nematicides.

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Microemulsion preparation of Waltheria indica extracts and preliminary antifungal mechanism exploration

Cited by 10 publications

References 66 publications

Antimicrobial activity of oridonin

Antimicrobial activity of oridonin

Sustainable Use of Chrysanthemum indicum var. aromaticum as Value-Added Green Materials in Microemulsion Hydrogels

Synthesis of Hinokitiol Sulfonate Derivatives and Their Anti‐Oomycete and Nematicidal Activities

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