Microemulsion Based Nanostructures for Drug Delivery

Abstract

Most of the active pharmaceutical compounds are often prone to display low bioavailability and biological degradation represents an important drawback. Due to the above, the development of a drug delivery system (DDS) that enables the introduction of a pharmaceutical compound through the body to achieve a therapeutic effect in a controlled manner is an expanding application. Henceforth, new strategies have been developed to control several parameters considered essential for enhancing delivery of drugs. Nanostructure synthesis by microemulsions (ME) consist of enclosing a substance within a wall material at the nanoscale level, allowing to control the size and surface area of the resulting particle. This nanotechnology has shown the importance on targeted drug delivery to improve their stability by protecting a bioactive compound from an adverse environment, enhanced bioavailability as well as controlled release. Thus, a lower dose administration could be achieved by minimizing systemic side effects and decreasing toxicity. This review will focus on describing the different biocompatible nanostructures synthesized by ME as controlled DDS for therapeutic purposes.

Role of surface‐active materials (amphiphiles and surfactants) in the formation of nanocolloidal dispersions, and their applications

“…Enthalpy formation of the reactions in the water pools during droplet fusion was endothermic for the copper ferrocyanide complex formation whereas it was exothermic for the formation of tungstic acid. A very recent publication reviews the ME based nanostructure for drug delivery in some detail (Arredondo‐Ochoa & Silva‐Martinez, 2022).…”

Self-Assembled Aggregated Structures of Natural Products for Oral Drug Delivery

“…They facilitate drug release by diffusion and can be eliminated from the bloodstream via the reticuloendothelial system. 26 Materials like poly(lactic-co-glycolic acid) (PLGA), especially when modified with PEG for improved hydrophilicity and prolonged blood circulation time, are of particular interest for their excellent carrier capability for both hydrophilic and hydrophobic drugs. 27 For encapsulation of hydrophilic drug, it is convenient to carry out functionalization of the PLGA nanoparticles with hydrophilic molecules such as polyethylene glycol (PEG) to potentiate the transport and drug release properties of this system.…”

Activities against Lung Cancer of Biosynthesized Silver Nanoparticles: A Review

“…However, their use can involve equipment with a high energy consumption, require long periods to achieve optimal operating temperatures, and may provide low product yields. In the same context, chemical methods (e.g., microemulsion and sol-gel) represent a fast and efficient approach to synthesizing nanostructures with the capacity to entrap and release therapeutic compounds using external or internal stimuli (e.g., light, pH, or temperature) [123,124]. However, their implementation often involves the use of hazardous organic solvents (e.g., hydrazine and dimethyl formamide), physical conditions that are challenging to achieve (e.g., vacuum pressure and high temperatures), and the final products can become easily destabilized under biological conditions [11,125].…”