Microelement Profile and Structure of Regionallymph Nodes During Senile Involution of Lymphoid Tissue

Abstract

The microelement profile and structure of lymph nodes were studied in experiment using old Wistar rats by means of a morphological method and the X-ray fluorescent analysis with synchrotron radiation. Their special qualitative and quantitative status is formed in regional lymph nodes that reflect age-related dynamics of lymphoid tissue. The content of trace elements and the size of compartments differ in lymph nodes of different localization. Age-related modifications in a microelement profile are characterized by proliferation of lymphoid cells, development of compartments and initiation of a corresponding immune response at the level of regional lymph nodes with different contact to external environment. Localization of lymph nodes is one of conditions for realization of the principle of a regional determinant (regional specifics).

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

“…Lymph nodes have great functional importance for the body, both in normal and pathological processes [ 33 , 34 , 35 ]. The lymph node plays a crucial role in the pathogenesis of inflammation [ 36 , 37 , 38 ].…”

Lymph Flow and Cellular Composition, Rheological Properties of Lymph and Blood in Animals With Experimental Peritonitis

“…The role of the lymphatic system in the pathology of internal organs and body systems is known; the authors found that the natural way to cleanse the focus of inflammation is regional lymphatic capillaries, vessels and lymph nodes, as well as its huge role in maintaining the constants of the internal environment [11,12].…”

Regional principle of aging dynamics of visceral lymph nodes of different lymphatic region

“…The lymph node is a triedic homeostatic system including structural (lymphoid), hydration, and trace elements parts. These components allow to maintain lymph node workability in different periods of life [2]. The purpose of the study is to determine the intensity of age-induced changes of visceral lymph nodes including the structure, hydration and concentration of trace elements.…”

“…We used the following a histological method, thermogravimetric method [3], X-ray fluorescence analysis using synchrotron radiation (RFA SI) [4] and statistical method using the StatPlus Pro 2009 program with determination of basic indicators. Results: The emergence of lymph theory of aging and concept of lymph region [1,2] poses the need to take into account changes in regional lymph node in aging. Not knowing what happens in organs and regional lymph nodes, we cannot consider agedependent changes (aging) in isolation.…”

“…The mesenteric lymph node is more susceptible to senile changes, as its parameters regarding structure, hydration, and trace elements differ significantly from the base level. Senile changes are explained by the peculiarity of the lymphatic region, which includes the "organ -lymph node" system, where the organ is dominant, as it directly contacts the external environment [1,2]. Conclusion: Age changes in mesenteric and tracheobronchial lymph nodes occur at different rates.…”