Microelectrode Arrays: Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping (Adv. Mater. Technol. 7/2021)

Chen, Zhiyuan; Boyajian, Nicolas; Lin, Zexu; Yin, Rose T.; Obaid, Sofian N.; Tian, Jinbi; Brennan, Jaclyn A.; Chen, Sheena W.; Miniovich, Alana N.; Lin, Leqi; Qi, Yarong; Liu, Xitong; Efimov, Igor R.; Lu, Luyao

doi:10.1002/admt.202170041

Cited by 4 publications

(4 citation statements)

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“…Besides brain electrical stimulation, optogenetics-based neuronspecific modulation for further neuroscience research has greater synergy when accompanied by electrophysiological approaches. [63][64][65] However, when light energy of a certain frequency is applied to the surface of the electrode, a photoelectric potential is generated by the exerted charge. [65,66] This voltage is recorded together when measuring electrophysiology through electrodes and is combined with actual neural activity signals to cause signal contamination.…”

Section: In Vivo Simultaneous Electrophysiology With Optogeneticsmentioning

confidence: 99%

MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

Cho,

Kim,

Dutta

et al. 2023

Adv Funct Materials

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Simultaneous monitoring of electrophysiology and magnetic resonance imaging (MRI) could guide the innovative diagnosis and treatment of various neurodegenerative diseases that are previously impossible. However, this technique is difficult because the existing metal‐based implantable neural interface for electrophysiology is not free from signal distortions from its intrinsic magnetic susceptibility while performing an MRI of the implanted area of the neural interface. Moreover, brain tissue heating from neural implants generated by the radiofrequency field from MRI poses potential hazards for patients. Previous studies with soft polymer‐based electrode arrays provide relatively suitable MRI compatibility but does not guarantee high‐resolution electrophysiological signal acquisition and stimulation performance. Here, MRI compatible, optically transparent flexible implantable device capable of electrophysiological multichannel mapping and electrical stimulation is introduced. Using the device, neuropathic pain (NP) relief with a 30‐channel electrophysiological mapping of the somatosensory area before and after motor cortex stimulation (MCS) in allodynia rats after noxious stimulation is confirmed. Additionally, artifact‐free manganese‐enhanced MRI of dramatic relief of pain‐related region activity by MCS is demonstrated. Furthermore, artifact‐free optogenetics with transgenic mice is also investigated by recording light‐evoked potentials. These results suggest a promising neuro‐prosthetic for analyzing and modulating spatiotemporal neurodynamic without MRI or optical modality resolution constraints.

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Section: In Vivo Simultaneous Electrophysiology With Optogeneticsmentioning

confidence: 99%

MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

Cho,

Kim,

Dutta

et al. 2023

Adv Funct Materials

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“…Au and Ag are frequently chosen as microelectrode materials in bioimplantable devices due to their excellent biocompatibility. [254,255] The metallic micro-mesh can function as the electrode with the required optical transmission and electrical impedance, but the effective abiotic/biotic interfacial surface recording area is greatly reduced by the wide opening between metal lines. The integration of additional transparent conductive thin films demonstrates high-performance electrophysiology and optogenetics for in vivo histology experiments, as shown in Figure 10b.…”

Section: Implantable Devicesmentioning

confidence: 99%

Metallic Micro‐Nano Network‐Based Soft Transparent Electrodes: Materials, Processes, and Applications

Chen,

Khan,

Dai

et al. 2023

Advanced Science

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Soft transparent electrodes (TEs) have received tremendous interest from academia and industry due to the rapid development of lightweight, transparent soft electronics. Metallic micro‐nano networks (MMNNs) are a class of promising soft TEs that exhibit excellent optical and electrical properties, including low sheet resistance and high optical transmittance, as well as superior mechanical properties such as softness, robustness, and desirable stability. They are genuinely interesting alternatives to conventional conductive metal oxides, which are expensive to fabricate and have limited flexibility on soft surfaces. This review summarizes state‐of‐the‐art research developments in MMNN‐based soft TEs in terms of performance specifications, fabrication methods, and application areas. The review describes the implementation of MMNN‐based soft TEs in optoelectronics, bioelectronics, tactile sensors, energy storage devices, and other applications. Finally, it presents a perspective on the technical difficulties and potential future possibilities for MMNN‐based TE development.

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“…AgNW have recently been explored as a transparent and flexible conductor for optical biointerfacing by Chen et al (Figure 14B). [542] as an alternative to previously reported brittle indium tin oxide (ITO) [552] and potentially cytotoxic carbon nanotubes (CNT). [552,553] As a proofofconcept, AgNW microelectrodes embedded in PDMS were used to measure a blue light excitable opsin, channelrhodopsin2, which is commonly measured to evaluate atrioventricular blockage in mice.…”

Section: Figure 14mentioning

confidence: 99%

Section: Figure 14mentioning

confidence: 99%

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

et al. 2022

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Designing bioelectronic devices that seamlessly integrate with the human body is a technological pursuit of great importance. Bioelectronic medical devices that reliably and chronically interface with the body can advance neuroscience, health monitoring, diagnostics, and therapeutics. Recent major efforts focus on investigating strategies to fabricate flexible, stretchable, and soft electronic devices, and advances in materials chemistry have emerged as fundamental to the creation of the next generation of bioelectronics. This review summarizes contemporary advances and forthcoming technical challenges related to three principal components of bioelectronic devices: i) substrates and structural materials, ii) barrier and encapsulation materials, and iii) conductive materials. Through notable illustrations from the literature, integration and device fabrication strategies and associated challenges for each material class are highlighted.

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Microelectrode Arrays: Flexible and Transparent Metal Nanowire Microelectrode Arrays and Interconnects for Electrophysiology, Optogenetics, and Optical Mapping (Adv. Mater. Technol. 7/2021)

Cited by 4 publications

References 0 publications

MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

MRI‐Compatible, Transparent PEDOT:PSS Neural Implants for the Alleviation of Neuropathic Pain with Motor Cortex Stimulation

Metallic Micro‐Nano Network‐Based Soft Transparent Electrodes: Materials, Processes, and Applications

Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine

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