Encyclopedia of Medical Devices and Instrumentation 2006
DOI: 10.1002/0471732877.emd330
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Microdialysis Sampling

Abstract: Microdialysis samplin is a well know in vivo collection method for low molecular weight hydrophilic analytes. This sampling method has its historical roots in the field of neuroscience since it is commonly used for collection of neurotransmitters. The successful application of microdialysis sampling for neuroscience applications has led to the expansion of the technique for collection of a wider range of analytes including drugs, metabolites, peptides and proteins. This article covers b… Show more

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Cited by 7 publications
(7 citation statements)
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“…[15,16] Microdialysis is a well established membrane-based technique in neurosciences and pharmacokinetic studies for in-vivo sampling of endogenous or xenobiotic compounds in discrete compartments of living systems. [17][18][19][20] Yet, current trends have been directed to expand the scope of this technique to the monitoring of bioprocesses (e.g. fermentations), [21,22] the assessment of the quality of foodstuffs [23][24][25] and cosmetics [26,27] and the probing of target species in environmentally relevant matrices.…”
Section: Introductionmentioning
confidence: 99%
“…[15,16] Microdialysis is a well established membrane-based technique in neurosciences and pharmacokinetic studies for in-vivo sampling of endogenous or xenobiotic compounds in discrete compartments of living systems. [17][18][19][20] Yet, current trends have been directed to expand the scope of this technique to the monitoring of bioprocesses (e.g. fermentations), [21,22] the assessment of the quality of foodstuffs [23][24][25] and cosmetics [26,27] and the probing of target species in environmentally relevant matrices.…”
Section: Introductionmentioning
confidence: 99%
“…We chose to use a higher perfusion fluid flow rate through the dialysis probe to obtain more analyte mass and thus use the sample preparation process as a means to concentrate the collected dialysates. For low molecular weight solutes, mass recovery in microdialysis sampling increases with increasing flow rates. …”
Section: Resultsmentioning
confidence: 99%
“…Microdialysis is a diffusion-based sampling method that has been used for four decades as an established research tool in life science and biomedical research. A perfusion fluid is passed through the device at microliter per minute flow rates, which induces the diffusion of analytes from the sample medium into the probe according to their concentration gradient. Since microdialysis relies on the same mode of action as plant roots during nutrient acquisition (diffusion), soil N fluxes during plant uptake can be measured reliably by employing microdialysis in the rhizosphere. , Due to the minimally invasive nature and small size of microdialysis, it is suitable for sampling soil microsites and providing real-time, in situ data with greater temporal and spatial resolutions than current standard, salt-solution extraction methods.…”
Section: Introductionmentioning
confidence: 99%