2011
DOI: 10.1111/j.1600-0625.2010.01212.x
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Microdialysis documents changes in the micromilieu of psoriatic plaques under continuous systemic therapy

Abstract: Microdialysis is a novel technique suitable to analyse soluble mediators in the skin compartment. We applied this methodical approach to monitor changes in the micromilieu of psoriatic plaques under therapy. Tissue fluid was collected from lesional and non-lesional skin of three patients with severe plaque-type psoriasis prior to as well as after 12 weeks of continuous oral therapy with fumaric acid esters. Concentrations of a spectrum of cytokines and adipokines were measured using a commercial fluorescent be… Show more

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Cited by 24 publications
(12 citation statements)
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“…It is well documented that dermal MD allows real-time measurement of inflammatory mediators in the dermis of normal as well as diseased skin (15). Being selective COX-2 inhibitor, Cxb suppresses prostanoid production involved in pain and inflammation (16).…”
Section: Introductionmentioning
confidence: 99%
“…It is well documented that dermal MD allows real-time measurement of inflammatory mediators in the dermis of normal as well as diseased skin (15). Being selective COX-2 inhibitor, Cxb suppresses prostanoid production involved in pain and inflammation (16).…”
Section: Introductionmentioning
confidence: 99%
“…In this context, it is of note that local cells are well capable of creating a local proinflammatory milieu (e.g. in a psoriatic plaque) without the responsible mediators necessarily being elevated in the circulation …”
mentioning
confidence: 99%
“…punch biopsies, suction blisters) can only be used for single time-point measurements as they are rather invasive and burdensome (6). Other methods such as dermal microdialysis are of limited use for large antibody molecules due to limited pore size of clinical membranes (7).…”
Section: Introductionmentioning
confidence: 99%