Microdialysis—A versatile technology to perform metabolic monitoring in diabetes and critically ill patients

Mader, Julia K.; Feichtner, Franz; Bock, Gerlies; Köhler, Gerd; Schaller, Roland; Plank, Johannes; Pieber, Thomas R.; Ellmerer, Martin

doi:10.1016/j.diabres.2012.02.010

Cited by 16 publications

(10 citation statements)

References 25 publications

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“…Similarly, in critically ill patients, relatively good correlations between blood and tissue glucose levels have been presented (with correlation factor values in the range of 0.74 to 0.88) [33][34][35]. Hyperlactatemia is invariably observed in metabolic stress and is a reliable indicator of ultimate prognosis [1][2][3].…”

Section: Discussionmentioning

confidence: 89%

Interrelationship between blood and tissue lactate in a general intensive care unit: A subcutaneous adipose tissue microdialysis study on 162 critically ill patients

Kopterides

Θεοδωρακοπούλου

Ilias³

et al. 2012

Journal of Critical Care

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Section: Discussionmentioning

confidence: 89%

Interrelationship between blood and tissue lactate in a general intensive care unit: A subcutaneous adipose tissue microdialysis study on 162 critically ill patients

Kopterides

Θεοδωρακοπούλου

Ilias³

et al. 2012

Journal of Critical Care

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“…The mannitol concentration for such application has been usually set to 5 % to have an isotonic perfusate. 5,6 For illustration of our concept, results from our previous CLINICIP project (see also www.clinicip.org) are also presented. For those measurement campaigns at the Medical University in Graz (Austria) CMA60 microdialysis probes from CMA Microdialysis AB (Solna, Sweden) were employed as microfluidic body interface.…”

Section: General Description Of the Micro-dialysis Catheters And Perfmentioning

confidence: 99%

“…4 For intensive care units, different approaches have been chosen, using either subcutaneously implanted microdialysis catheters, intravascularly inserted probes or extracorporeal microdialysis with continuously sampled and heparinised whole blood, from which dialysates have been obtained. [5][6][7][8][9][10][11] The latter microdialysis technique, as described in detail by Feichtner et al,7 has also been used by us in combination with infrared spectroscopy for ex-vivo glucose quantification. 12,13 Recently, an overview for continuous glucose monitoring (CGM) systems, based on electrochemical sensing as utilised in needle-type sensors directly implanted and micro-dialysis based systems for interstitial fluid or intravascular application with ex-vivo detection, has been given by Lucarelli et al 14 .…”

Section: Introductionmentioning

confidence: 99%

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry

et al. 2015

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Micro-dialysis has been established in the clinical environment for continuously harvesting body fluids, but a drawback of this process are variable recovery rates, which can be observed especially for subcutaneously implanted catheters. Perfusates with either acetate or mannitol have been investigated as recovery markers. The latter substance is suggested for application with external cavity tuneable quantum cascade lasers, rendering a limited wavenumber interval in contrast to FTIR-spectrometers. Despite the overlap of mannitol and glucose spectra, their simultaneous quantification was successful. By investigating the depletion of the marker substances from the perfusates using different micro-dialysis devices, the theoretical nonlinear relationship between the relative dialysate marker concentration and glucose recovery rate was confirmed for the marker substance-analyte pair of acetate and glucose, rendering a basis for reliable blood glucose measurements. For the pair of mannitol and glucose an almost linear dependency was expected for the microdialysate catheters and experimentally verified, which provides a straightforward correction of any dialysis recovery rate variation during patient monitoring.

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“…In vivo evaluations using cutaneous microdialysis have been used for quantification of cerebral neurotransmitters (Shearman et al, 2006;Cerbai et al, 2007;Shannon et al, 2013), glucose monitoring in diabetes mellitus (Mader et al, 2012), measurement of antibiotics levels (Roberts et al, 2008;K. Hurtado et al, 2014), and measurement of antineoplastic drug levels in the target tissue (Höcht, Opezzo, Taira, 2007).…”

Section: Cutaneous Microdialysismentioning

confidence: 99%

Evaluation of skin absorption of drugs from topical and transdermal formulations

Ruela

Perissinato

Lino

et al. 2016

Braz. J. Pharm. Sci.

207

135

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The skin barrier function has been attributed to the stratum corneum and represents a major challenge in clinical practice pertaining to cutaneous administration of drugs. Despite this, a large number of bioactive compounds have been successfully administered via cutaneous administration because of advances in the design of topical and transdermal formulations. In vitro and in vivo evaluations of these novel drug delivery systems are necessary to characterize their quality and efficacy. This review covers the most well-known methods for assessing the cutaneous absorption of drugs as an auxiliary tool for pharmaceutical formulation scientists in the design of drug delivery systems. In vitro methods as skin permeation assays using Franz-type diffusion cells, cutaneous retention and tape-stripping methods to study the cutaneous penetration of drugs, and in vivo evaluations as pre-clinical pharmacokinetic studies in animal models are discussed. Alternative approaches to cutaneous microdialysis are also covered. Recent advances in research on skin absorption of drugs and the effect of skin absorption enhancers, as investigated using confocal laser scanning microscopy, Raman confocal microscopy, and attenuated total reflectance Fourier-transform infrared spectroscopy, are reviewed. Uniterms:Skin absorption/effects/study. Skin absorption/topical formulations. Skin absorption/ transdermal formulations. Skin absorptions/enhancers. INTRODUCTIONTopical and transdermal drug delivery systems have shown significant advantages in clinical practice for drug targeting to the action site in the body; this has reduced the systemic side effects. The administration of drugs by through the skin is also performed to achieve controlled or prolonged drug delivery, and this route can be explored as an alternative to the oral route. The oral route shows some limitations for drugs with irregular absorption in the gastrointestinal tract and low bioavailability and for drugs with increased first pass metabolism and short plasma halflife times (Barry, 2001;Wokovich et al., 2006;Prausnitz, Langer, 2009;Alexander et al., 2012).Many drug products applied to the skin surface may penetrate to some extent into the skin layers, where their effects are expected. This is the case for topical formulations for treatment of skin disorders such as acne and cutaneous inflammatory diseases that include dermatitis, erythematous lupus, and psoriasis. On the other hand, transdermal formulations release drugs that permeate through the skin and enter the systemic circulation. Transdermal therapy must ensure that significant concentrations of the drug are absorbed to reach effective plasma concentrations. Permeation of drugs is targeted in some cases to body regions close to the action site, where a regional effect is expected, e.g., in the muscles, blood vessels, and articulations. In this way, the term "cutaneous absorption" is properly used to characterize the sum of the amounts of drug that penetrate and permeate the skin (Barry, 2001;El Maghraby, Barry;Willi...

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Microdialysis—A versatile technology to perform metabolic monitoring in diabetes and critically ill patients

Cited by 16 publications

References 25 publications

Interrelationship between blood and tissue lactate in a general intensive care unit: A subcutaneous adipose tissue microdialysis study on 162 critically ill patients

Interrelationship between blood and tissue lactate in a general intensive care unit: A subcutaneous adipose tissue microdialysis study on 162 critically ill patients

Ex-vivo glucose sensors using micro-dialysis: importance of on-line recovery rate determination by multi-analyte infrared spectrometry

Evaluation of skin absorption of drugs from topical and transdermal formulations

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