Microdevice Platform for In Vitro Nervous System and Its Disease Model

Choi, Jin‐Ha; Cho, Hyeon-Yeol; Choi, Jeong‐Woo

doi:10.3390/bioengineering4030077

Cited by 17 publications

(19 citation statements)

References 129 publications

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“…OOAC technology has developed rapidly in recent years and has enhanced our knowledge of all the major organs. Others not discussed in this review include blood vessels [99,114,115], the skin [116,117], the BBB [118,119], skeletal muscle [120,121], and the CNS [122,123].…”

Section: Multi-organs-on-a-chipmentioning

confidence: 99%

Organ-on-a-chip: recent breakthroughs and future prospects

et al. 2020

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BackgroundMicrofluidics is a science and technology that precisely manipulates and processes microscale fluids. It is commonly used to precisely control microfluidic (10 −9 to 10 −18 L) fluids using channels that range in size from tens to hundreds of microns and is known as a "lab-on-a-chip" [1][2][3][4]. The microchannel is small, but has a large surface area and high mass transfer, favoring its use in microfluidic technology applications including low regent usage, controllable volumes, fast mixing speeds, rapid responses, and precision control of physical and chemical properties [1,5,6]. Microfluidics integrate sample preparation, reactions, separation, detection, and basic operating units such as cell culture, sorting and cell lysis [7]. For these reasons, interest in OOAC has intensified [8]. OOAC combines a range of chemical, biological and material science disciplines [9] and was selected as one of the "Top Ten Emerging Technologies" in the World Economic Forum [10].OOAC is a biomimetic system that can mimic the environment of a physiological organ, with the ability to regulate key parameters including AbstractThe organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimulation. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. OOAC has broad applications in precision medicine and biological defense strategies. Here, we introduce the concepts of OOAC and review its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application.

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Section: Multi-organs-on-a-chipmentioning

confidence: 99%

Organ-on-a-chip: recent breakthroughs and future prospects

et al. 2020

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“…Compared with the conventional cell culture methods, microfluidic cell culture methods possess several attractive features, including continuous nutrient supply, less liquid consumption, ease of handling, less time consumption, and low costs. Hence, microfluidic systems are invaluable and versatile tools for cell-based assays [59,60]. Compartmentalized microfluidic systems (CMSs) [61,62] composed of multiple chambers separated by microgroove arrays, which allows the specific isolation of subcellular components (e.g., segregated axons and soma of the neurons) are particularly useful for studying neuron-neuron interaction, synapse formation, axon signaling, myelination, and other important parameters that are essential for understanding NDs [63,64].…”

Section: D Microfluidic Nd Modelsmentioning

confidence: 99%

In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device

2019

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The blood–brain barrier (BBB) plays critical role in the human physiological system such as protection of the central nervous system (CNS) from external materials in the blood vessel, including toxicants and drugs for several neurological disorders, a critical type of human disease. Therefore, suitable in vitro BBB models with fluidic flow to mimic the shear stress and supply of nutrients have been developed. Neurological disorder has also been investigated for developing realistic models that allow advance fundamental and translational research and effective therapeutic strategy design. Here, we discuss introduction of the blood–brain barrier in neurological disorder models by leveraging a recently developed microfluidic system and human organ-on-a-chip system. Such models could provide an effective drug screening platform and facilitate personalized therapy of several neurological diseases.

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“…136 Further models are summarised and reviewed in. 137,138 An important consideration when designing an in vitro model of the brain is interstitial fluid flow. In vitro, the main roles of interstitial fluid are carried out by the cell culture medium, namely providing the cells with nutrients and removing waste during media changes.…”

Section: Networked Neurospheresmentioning

confidence: 99%

Tissue engineered organoids for neural network modelling

Kose-Dunn¹,

Fricker²,

Roach³

2017

ATROA

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The increased prevalence of neurological diseases across the world has stimulated a great deal of research into the physiological and pathological brain, both at clinical and pre-clinical level. This has led to the development of many sophisticated tissue engineered neural models, presenting greater cellular complexity to better mimic the central nervous system niche environment. These have been developed with the ambition to improve pre-clinical assessment of pharma and cellular therapies, as well as better understand this tissue type and its function/dysfunction. This review covers the necessary considerations in in vitro model design, along with recent advances in 2Dculture systems, to 3D organoids and bio-artificial organs.

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Microdevice Platform for In Vitro Nervous System and Its Disease Model

Cited by 17 publications

References 129 publications

Organ-on-a-chip: recent breakthroughs and future prospects

Organ-on-a-chip: recent breakthroughs and future prospects

In Vitro Blood–Brain Barrier-Integrated Neurological Disorder Models Using a Microfluidic Device

Tissue engineered organoids for neural network modelling

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