Microdetermination of Volatile Aldehydes

Hunter, Irving R.; Potter, Earl F

doi:10.1021/ac60134a038

Cited by 18 publications

(4 citation statements)

References 4 publications

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“…The Schiff base formed from methionine and 2,3-butanedione would produce ammonia and 3-(methylthio)propanal (methional) via Strecker degradation upon release of the carbonyl compound as proposed by Mottram and co-workers [6]. This mechanism is similar to the well-known formation of methional from methionine treated with ninhydrin, which converts the amino acid to the corresponding imino acid that subsequently breaks down into methional, carbon dioxide, and ammonia by hydrolysis [41][42][43]. Methional can form methanethiol and acrolein via retro Michael cleavage.…”

Section: Biodieselmentioning

confidence: 75%

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

Stevens

Maier

2008

Molecular Nutrition Food Res

615

634

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Acrolein (2-propenal) is ubiquitously present in (cooked) foods and in the environment. It is formed from carbohydrates, vegetable oils and animal fats, amino acids during heating of foods, and by combustion of petroleum fuels and biodiesel. Chemical reactions responsible for release of acrolein include heat-induced dehydration of glycerol, retro-aldol cleavage of dehydrated carbohydrates, lipid peroxidation of polyunsaturated fatty acids, and Strecker degradation of methionine and threonine. Smoking of tobacco products equals or exceeds the total human exposure to acrolein from all other sources. The main endogenous sources of acrolein are myeloperoxidase-mediated degradation of threonine and amine oxidase-mediated degradation of spermine and spermidine, which may constitute a significant source of acrolein in situations of oxidative stress and inflammation. Acrolein is metabolized by conjugation with glutathione and excreted in the urine as mercapturic acid metabolites. Acrolein forms Michael adducts with ascorbic acid in vitro, but the biological relevance of this reaction is not clear. The biological effects of acrolein are a consequence of its reactivity towards biological nucleophiles such as guanine in DNA and cysteine, lysine, histidine, and arginine residues in critical regions of nuclear factors, proteases, and other proteins. Acrolein adduction disrupts the function of these biomacromolecules which may result in mutations, altered gene transcription, and modulation of apoptosis.

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Section: Biodieselmentioning

confidence: 75%

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

Stevens

Maier

2008

Molecular Nutrition Food Res

615

634

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“…Volatile products were collected in cold traps or were trapped in sodium bisulfite solution. The products were analyzed by gas-liquid chromatography (glc) of the condensates or by titration of the bisulfite solutions (Hunter and Potter, 1958). To obtain a more sensitive analysis, l-[35S]methionine, ¿V-[35S]acetyl-L-methionine, and N-[35S]formyl-L-methionine were prepared and allowed to react with ninhydrin in a NaaHPOé-NaHaPOí buffer (0.1 M, pH 7.0) at 100°for 1 hr.…”

Section: Methodsmentioning

confidence: 99%

An Investigation of N-Substituted methionine derivatives for food supplementation

Damico¹

1975

J. Agric. Food Chem.

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DAMICOing a glutamic acid enriched plastein in a high yield.(2) Such a plastein, though nondialyzable, was of a low molecular nature compared with an ordinary plastein. (3) Both the high glutamic acid content and the low molecular nature of this plastein seemed to cause its water solubility and stability to heating. (4) It was demonstrated that the enriched glutamic acid residue had a significant contribution to several physicochemical properties of the enzymatically synthesized polypeptides. (5) A possibility is expected that the plastein reaction can be applied to create some new functional properties from proteins.

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“…Sodium bisulfite was used for the fixation of atmospheric carbonyl compounds, notably formaldehyde (457), after which iodometric titration was carried out. Other aldehydes and ketones have been similarly estimated (182,457).…”

Section: Sulfur and Compoundsmentioning

confidence: 99%

Air Pollution

Kay¹

1959

Anal. Chem.

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Microdetermination of Volatile Aldehydes

Cited by 18 publications

References 4 publications

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

Acrolein: Sources, metabolism, and biomolecular interactions relevant to human health and disease

An Investigation of N-Substituted methionine derivatives for food supplementation

Air Pollution

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