Microdeletions in the Y chromosome and recurrent reproductive loss.

Nani, J.M; Brasch, Joel; Summers, Robert W.; Springer, R.; Jeyendran, Rajasingam S.

doi:10.1016/s0015-0282(01)02050-7

Cited by 1 publication

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“…24 The first suggestion of an existing relationship between Y chromosome microdeletions and RPL was proposed by Nani et al at a meeting. 25 They studied 18 loci of the AZF region of the Y chromosome in seven patients and found microdeletions of DYS236 in five patients (71.4%). 25 Consequently, they proposed, for the first time, the screening of Y chromosome microdeletions as a work-up tool for the males of couples with RPL.…”

Section: Introductionmentioning

confidence: 99%

Y chromosome microdeletions in Mexican males of couples with idiopathic recurrent pregnancy loss

Piña-Aguilar

Martı́nez-Garza²,

Kohls³

et al. 2012

J of Obstet and Gynaecol

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Aim: To analyze the presence of Y chromosome microdeletions in males of Mexican couples with idiopathic recurrent pregnancy losses (RPL). Methods: Seventy-one males from couples with RPL and 66 fertile males as controls were studied. DNA was isolated from peripheral lymphocytes and used to run multiplex polymerase chain reactions. Regions AZFa (sY84, sY86), AZFb (sY127, sY134) and AZFc (sY254, sY255) of the Y chromosome were analyzed according to valid guidelines recommended by the European Academy of Andrology and the European Molecular Genetics Quality Network. Also, the sequence tagged sites (STSs): DYS262 (sY67), DYS220 (sY129), DYF85S1 (sY150), DYF86S1 (sY152) and DYF87S1 (sY153) were included in order to analyze STSs previously reported as deleted. A power analysis to support our simple size was performed. Results: Results show an absence of Y chromosome microdeletions in males of couples with RPL and controls with an acceptable statistical power. Conclusion:The study did not show an association of recurrent pregnancy loss and Y chromosome microdeletions in Mexican male partners. Based on the results, the study of Y chromosome microdeletions in couples with RPL is not considered clinically relevant.

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Section: Introductionmentioning

confidence: 99%