Microcytic anemia associated with mTOR or calcineurin inhibition: An unusual situation after allogeneic hematopoietic stem cell transplantation

Remacha, Ángel F.; Monter‐Rovira, Anna; Santfeliu, Albert Esquirol; Payán-Pernía, Salvador; Bofarull, Rodrigo Martino; García‐Cadenas, Irene; Mauri, S. Brunet; Gil, J.M.

doi:10.1111/ijlh.13178

Cited by 3 publications

(2 citation statements)

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“…Despite being highly influenced by kinases, relatively few erythropoiesis deficiencies are currently attributed to deregulated kinase activity. The most characterized of these are pyruvate kinase, DYRK3, mTORC1, p38/JNK, and NLK [21][22][23]25,[59][60][61].…”

Section: Kinases and Anemiamentioning

confidence: 99%

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Signaling Pathways That Regulate Normal and Aberrant Red Blood Cell Development

Wilkes

Shibuya

Sakamoto

2021

Genes

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Blood cell development is regulated through intrinsic gene regulation and local factors including the microenvironment and cytokines. The differentiation of hematopoietic stem and progenitor cells (HSPCs) into mature erythrocytes is dependent on these cytokines binding to and stimulating their cognate receptors and the signaling cascades they initiate. Many of these pathways include kinases that can diversify signals by phosphorylating multiple substrates and amplify signals by phosphorylating multiple copies of each substrate. Indeed, synthesis of many of these cytokines is regulated by a number of signaling pathways including phosphoinositide 3-kinase (PI3K)-, extracellular signal related kinases (ERK)-, and p38 kinase-dependent pathways. Therefore, kinases act both upstream and downstream of the erythropoiesis-regulating cytokines. While many of the cytokines are well characterized, the nuanced members of the network of kinases responsible for appropriate induction of, and response to, these cytokines remains poorly defined. Here, we will examine the kinase signaling cascades required for erythropoiesis and emphasize the importance, complexity, enormous amount remaining to be characterized, and therapeutic potential that will accompany our comprehensive understanding of the erythroid kinome in both healthy and diseased states.

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Section: Kinases and Anemiamentioning

confidence: 99%

“…Pyruvate kinase-Central to red blood cell production is glycolysis, and the conversion of phosphenolpyruvate to pyruvate yields 50% of the ATP required for erythropoiesis [61]. The enzyme that catalyzes this reaction in pyruvate kinase.…”

Section: Kinases and Anemiamentioning

confidence: 99%